Mean Dice’s similarity index computed for , , .

<p>Locally Linear Embedding is in blue, Isomap is in red and Laplacian Eigenmaps is in black. Solid lines represent the mean Dice’s similarity index, doted lines represents the standard deviation. Mean Dice’s similarity index against: () the number of atlases fused in STAPLE ( and fixed to best parameters), () the neighbourhood size in computing the manifold ( and fixed to best parameters), and () the manifold dimension ( and fixed to best parameters).</p

Mean (SD) of the volumes (in mm³) in the left hippocampus in the baseline images of the atlas library of 110 images used to assess optimal methods and parameters.

<p>Mean (SD) of the volumes (in mm³) in the left hippocampus in the baseline images of the atlas library of 110 images used to assess optimal methods and parameters.</p

Hippocampal segmentation: automated (blue) vs manual (red).

<p>Overlapping area in purple. Row: (i) High case (Dice = 0.9398), (ii) Typical case (Dice = 0.9073), (iii) Low case (Dice = 0.8614). Column: (a) Coronal view, (b) Sagittal view, (c) Axial view.</p

Subject demographics in set of 30 labelled randomly selected subjects used for method validation.

<p>Mean (SD) unless specified otherwise.</p

Bland-Altman plot.

<p>Each point corresponds to an hippocampal segmentation. The difference between automatic and manual estimates is plotted against their average. The solid horizontal line corresponds to the average difference, and the dashed lines are plotted at average +/−1.96 standard deviations of the difference.</p

Subject demographics in control and probable AD subjects used for parameter optimization. Mean (SD) unless specified otherwise.

<p>Subject demographics in control and probable AD subjects used for parameter optimization. Mean (SD) unless specified otherwise.</p

Mean Dice’s similarity indexes (SD) obtained with manifold learning selection (LLE, ISO, LEM) and plain selection (BASE).

<p>-values comparing each approach with each other are reported.</p

Average Dice’s similarity index for NC, MCI and AD group obtained by fusing top 7 atlases with STAPLE.

<p>Atlases were selected with manifold learning.</p

Mean (SD) of the volumes (in mm³) in the left hippocampus in the baseline images of the labelled ADNI data set of 30 images for method validation.

<p>Mean (SD) of the volumes (in mm³) in the left hippocampus in the baseline images of the labelled ADNI data set of 30 images for method validation.</p

Similarity between P1 and P2 networks across density thresholds using atlases at three node scales.

<p>Significance of similarity was calculated by comparing the distribution of within-subject DC to the expected DC by chance, given the density of the networks. Shown is the mean negative -value of the DC between binary networks thresholded at a given density. The within-subject DC's were bootstrapped to obtain a standard error on the mean (dashed lines). A global peak similarity was found at a density of 0.196, 0.161, 0.106 and 0.142 for the Common (34 nodes), Hammers (44 nodes), Desikan-Killiany (68 nodes) and AAL (78 nodes) atlases, respectively.</p