Endothelial function, regulation of angiogenesis and embryonic central hemodynamics in ART-conceived pregnancies

This study was undertaken to compare the concentrations of pro- and anti-angiogenic growth factors, nitric oxide (NO) stable metabolites in maternal serum and embryonic left ventricular (LV) isovolumic relaxation time (IRT, ms) during the first trimester in two groups of women: with pregnancy conceived by assisted reproductive technologies (ART, nј39) and normally conceived (control group, nј68) pregnancy. The concentration of vasoconstrictor endothelin 1 was 45.5 times more in ART than in control group. On the contrary, the concentrations of NO stable metabolites in ART were 1.9 times less than in control women. The assessment of angiogenic suppressors in ART women demonstrates the decrease in s-endoglin concentration was 1.6 times and in soluble receptor to vascular endothelial growth factor concentration was 2.0 times in comparison with control group. There was a significant increase in LV IRT in ART embryos in comparison to control ones. These data suggest significant changes in pro-antiangiogenic factors balance and increase in vascular impedance in ART-conceived embryos

Comparative analysis of pregnancy development and output after assisted reproductive technologies at different variants of hormonal support (preliminary results)

The duration of hormonal support after assisted reproductive technologies (ART) and different used medicines is steel questionable. The analysis of development and pregnancy output of patients with monofetal pregnancy after ART was performed 10 patients received monotherapy (didrogesterone) and 22 patients received several hormonal preparations. There were no significant differences between these two groups of patients in terms of pregnancy output and complications.Вопрос продолжительности гормональной поддержки после применения вспомогательных репродуктивных технологий (ВРТ) и спектра применяемых препаратов остается обсуждаемым в литературе. С целью оценки возможности использования монотерапии проведен анализ течения и исходов беременности 10 пациенток с одноплодной беременностью после ВРТ, получавших в качестве поддержки единственный препарат-дидрогестерон, составивших основную группу, и 22 пациенток, получавших несколько гормональных препаратов, составивших группу сравнения. В результате исследования не выявлено значимых различий между группами в развитии осложнений беременности и ее исходов

The application of the «Lavomax» preparation as a part of complex therapy at rehabilitation of women with infringements of reproductive function on the pregravid stage in comparison with standard therapy

The investigation of 60 women of reproductive age at a pregravid preparations stage is carried for the purpose of an estimation of efficiency of therapy by a preparation «Lavomax» as a part of complex therapy for rehabilitation of women with infringement of reproductive function in comparison with efficiency of standard therapy. Convincing proofs of clinical efficiency and shipping of a «Lavomax» preparation are received, that allows to recommend it in clinical practice in complex treatment of sexual-transmissie infections.Проведено обследование 60 женщин репродуктивного возраста на этапе предгравидарной подготовки с целью оценки эффективности терапии препаратом «Лавомакс» в составе комплексной терапии для реабилитации женщин с нарушением репродуктивной функции в сравнении с эффективностью стандартной терапии. Получены убедительные доказательства клинической эффективности и переносимости препарата «Лавомакс», что позволяет рекомендовать его в клинической практике в комплексном лечении секуально-трансмиссивных инфекций

Results of a Joint Epizootiological Survey of Transboundary Natural Plague Foci of the Russian Federation and Potentially Focal Territories of the Republic of Kazakhstan in 2019–2022

Consolidation of the efforts in implementation of epidemiological surveillance and control over plague and other dangerous natural-focal infections is an essential aspect in ensuring epidemiological well-being as regards particularly dangerous infectious diseases in the territory of natural plague foci and potentially focal territories located within the borders of the Russian Federation and the Republic of Kazakhstan. The aim of the work was to carry out a joint epizootiological survey of the transboundary territories of the Volga-Ural sandy natural plague focus and the territory of the East Kazakhstan region of the Republic of Kazakhstan (RK) potentially focal for plague over the period of 2019–2022. Materials and methods. Samples of field materials, collected during the epizootiological survey of the territory of Kazakhstan, were studied using bacteriological, molecular-genetic, and immune-serological methods. Results and discussion. We have obtained the current evidence on the spatial-biocenotic structure, the circulation of pathogens of dangerous natural-focal infectious diseases in the transboundary territories of Eastern and Western Kazakhstan. It has been established that the conditions that contribute to the possibility of human infection with plague and other dangerous infectious diseases in case of the aggravation of epizootic situation in the foci or importation of the pathogens into the territory are in place

Supersymmetric QCD corrections to e+e−→tbˉH−e^+e^-\to t\bar{b}H^- and the Bernstein-Tkachov method of loop integration

The discovery of charged Higgs bosons is of particular importance, since their existence is predicted by supersymmetry and they are absent in the Standard Model (SM). If the charged Higgs bosons are too heavy to be produced in pairs at future linear colliders, single production associated with a top and a bottom quark is enhanced in parts of the parameter space. We present the next-to-leading-order calculation in supersymmetric QCD within the minimal supersymmetric SM (MSSM), completing a previous calculation of the SM-QCD corrections. In addition to the usual approach to perform the loop integration analytically, we apply a numerical approach based on the Bernstein-Tkachov theorem. In this framework, we avoid some of the generic problems connected with the analytical method.Comment: 14 pages, 6 figures, accepted for publication in Phys. Rev.

The cardiovascular system in children conceived by assisted reproductive technologies

The paper gives data on the impact of assisted reproductive technologies (ART) on the cardiovascular system and metabolism in children and adults conceived by the above technologies. It issuggested that epigenetic exposures may be a main mechanism for programming cardiovascular and metabolic abnormalities in the later life of these children