Recent Work On Dispute Resolution By The United Nations Commission On International Trade Law

My assignment today is to discuss the recent work of the United Nations Commission on International Trade Law ( UNCITRAL ) in the field of arbitration and other forms of dispute resolution

Judicial Application Of The Convention On The Recognition And Enforcement Of Foreign Arbitral Awards

When we look at the Convention on the Recognition and Enforcement of Foreign Arbitral Awards, we must ask ourselves, who recognizes foreign arbitral awards and who enforces the

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Significance Alzheimer’s disease (AD) is the most common cause of dementia and is a major public health problem for which there is currently no disease-modifying treatment. There is an urgent need for greater understanding of the molecular mechanisms underlying neurodegeneration in patients to create better therapeutic options. Recently, genetic studies uncovered novel AD risk variants in the microglial receptor, triggering receptor expressed on myeloid cells 2 (TREM2). Previous studies suggested that loss of TREM2 function worsens amyloid-β (Aβ) plaque-related toxicity. In contrast, we observe TREM2 deficiency mitigates neuroinflammation and protects against brain atrophy in the context of tau pathology. These findings indicate dual roles for TREM2 and microglia in the context of amyloid versus tau pathology, which are important to consider for potential treatments targeting TREM2.</jats:p