The petrogenesis of Carboniferous-Permian dyke and sill intrusions across northern Europe

The presence or absence of a thermally anomalous mantle plume during the formation of the widespread Carboniferous-Permian magmatism of northern Europe is examined. The geochemistry of representative samples from the extensive Carboniferous-Permian dyke and sill intrusions across northern Europe are reported in order to ascertain whether they have a common 'plume' source. Both tholeiitic and alkaline magmas have diverse trace element compositions. Alkaline samples with relatively low Ti and Nb/La 1 from the asthenosphere. The tholeiites have a close affinity to E-MORB but have mixed with variable amounts of lithosphere and upper crust. Tectonic reorganisation and decompression melting of a trace element-enriched mantle is considered to have controlled the Carboniferous-Permian magmatism, which contains no coherent geochemical evidence for a single plume-related thermo-chemical anomaly. © Springer-Verlag 2006

Regional hyperinsulinemia induces vasodilation but does not modulate adrenergic responsiveness in humans

Contains fulltext : 22886___.PDF (publisher's version ) (Open Access

Late Proterozoic tectonic events in southern Finland, constrained by Ar-40/Ar-39 incremental heating and single spot fusion experiments on K-feldspars.

The post-Svecofennian tectonic development of southern Finland is controlled by intrusion of rapakivi granites (and associated rocks), reactivation of Svecofennian wrench zones, formation of sedimentary basins and successive intrusion of olivine dolerite dykes and sills. Relative age determinations have revealed that fault reactivation acted before, simultaneously and after intrusion of the rapakivi granites. Results o

Residential Halls for Men Summer Session

Official Publication of Cornell University V.30 1938/3

Population pharmacokinetics and pharmacodynamics in anesthesia, intensive care and pain medicine

Purpose of review Population modeling is a relatively new pharmacological discipline, the development of which has largely been stimulated by the need for accurate models for the pharmacokinetics and dynamics of anesthetic agents. Recent findings Population-based modeling is now considered superior to older, more traditional modeling methods. Nonlinear mixed-effect modeling - a commonly used population-based modeling approach - estimates intraindividual and interindividual variability, limits the influence of outlying samples and individuals through the use of Bayesian statistical analysis, and provides a potential means of optimizing drug delivery regimens, especially when used to define pharmacokinetic-dynamic models for target-controlled infusion systems. In addition to being used for pharmacokinetic modeling, in which the influence of factors such as age, weight and illness can be studied, it is a powerful tool for the study of the influence of multiple factors on drug pharmacodynamics. Summary Nonlinear mixed-effect population-based modeling has become the gold standard method of pharmacokinetic and pharmacodynamic analysis during new drug development and during subsequent pharmacological studies. Population-based modeling techniques have been applied to numerous aspects of drug delivery in anesthesia, intensive care and pain medicine