Efficient radio resource allocation in SDN/NFV based mobile cellular networks under the complete sharing policy

Novel networking paradigms, such as software-defined networking (SDN) and network function virtualisation (NFV), introduce new opportunities in the design of next-generation mobile networks. The present work investigates the benefits of the emerging SDN and NFV technologies on the radio resource management (RRM) in mobile cellular networks. In particular, the aim of the proposed RRM scheme is to enable an efficient and flexible radio resource allocation in order to assure quality of experience of mobile users. The authors consider the orthogonal frequency division multiple access scheme and the complete radio resource sharing policy. To enable time- and space-efficient resource allocation, the authors investigate the applicability of the well-known Kaufman–Roberts recursion in the context of new architectural and functional changes of SDN/NFV based mobile environments. Finally, they discuss the applicability of the proposed approach for more complicated resource sharing policies

EGF increases expression and activity of PAs in preimplantation rat embryos and their implantation rate

BACKGROUND: Embryo implantation plays a major role in embryogenesis and the outcome of pregnancy. Plasminogen activators (PAs) have been implicated in mammalian fertilization, early stages of development and embryo implantation. As in-vitro developing embryos resulted in lower implantation rate than those developed in-vivo we assume that a reduced PAs activity may be involved. In the present work we studied the effect of EGF on PAs activity, quantity and embryo implantation. METHODS: Zygotes were flushed from rat oviducts on day one of pregnancy and grown in-vitro in R1ECM supplemented with EGF (10 ng/ml) and were grown up to the blastocyst stage. The control groups were grown in the same medium without EGF. The distribution and quantity of the PAs were examined using fluorescence immunohistochemistry followed by measurement of PAs activity using the chromogenic assay. Implantation rate was studied using the embryo donation model. RESULTS: PAs distribution in the embryos was the same in EGF treated and untreated embryos. Both PAs were localized in the blastocysts' trophectoderm, supporting the assumption that PAs play a role in the implantation process in rats. EGF increased the quantity of uPA at all stages studied but the 8-cell stage as compared with controls. The tissue type PA (tPA) content was unaffected except the 8-cell stage, which was increased. The activity of uPA increased gradually towards the blastocyst stage and more so due to the presence of EGF. The activity of tPA did not vary with the advancing developmental stages although it was also increased by EGF. The presence of EGF during the preimplantation development doubled the rate of implantation of the treated group as compared with controls