27 research outputs found
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.
Get PDFCO-DEPOSITION OF IRON AND NICKEL ON NANOGRAPHITE FOR MICROWAVE ABSORPTION THROUGH FLUIDIZED BED ELECTROLYSIS
No full textS733 DEEP CERVICAL PLEXUS BLOCK IN THE TREATMENT OF ACUTE AND CHRONIC PAIN OF HEAD AND ARM
No full textGalvanic deposition of aluminium alloys
No full text14.00; Translated from Czech (Hutn. Listy 1987 v. 42(5) p. 335-338)SIGLEAvailable from British Library Document Supply Centre- DSC:9023.19(VR--3460)T / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Yeast Cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication
No full textElectro-deposition of aluminium-lead alloys on metal base
No full text14.25; Translated from Czech (Hutn. Listy 1984 v. 5 p. 340-343)SIGLEAvailable from British Library Document Supply Centre- DSC:9022.06(BISI--23533)T / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Anthracycline based chemotherapy decreases amplification status of Her-2/neu and topoisomerase II alpha genes in locally advanced breast cancer
No full textAnthracycline based chemotherapy decreases amplification status of Her-2/neu and topoisomerase II alpha genes in locally advanced breast cancer
No full text
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Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34.
No full textSCFCdc4 (Skp1, Cdc53/cullin, F-box protein) defines a family of modular ubiquitin ligases (E3s) that regulate diverse processes including cell cycle, immune response, and development. Mass spectrometric analysis of proteins copurifying with Cdc53 identified the RING-H2 finger protein Hrt1 as a subunit of SCF. Hrt1 shows striking similarity to the Apc11 subunit of anaphase-promoting complex. Conditional inactivation of hrt1(ts) results in stabilization of the SCFCdc4 substrates Sic1 and Cln2 and cell cycle arrest at G1/S. Hrt1 assembles into recombinant SCF complexes and individually binds Cdc4, Cdc53 and Cdc34, but not Skp1. Hrt1 stimulates the E3 activity of recombinant SCF potently and enables the reconstitution of Cln2 ubiquitination by recombinant SCFGrr1. Surprisingly, SCF and the Cdc53/Hrt1 subcomplex activate autoubiquitination of Cdc34 E2 enzyme by a mechanism that does not appear to require a reactive thiol. The highly conserved human HRT1 complements the lethality of hrt1Delta, and human HRT2 binds CUL-1. We conclude that Cdc53/Hrt1 comprise a highly conserved module that serves as the functional core of a broad variety of heteromeric ubiquitin ligases
