6 research outputs found
MULTIPLE HIGH CURRENT BUNCHES IN PEP-II
Operation with colliding beams at PEP-II has progressed remarkably well with over half the design specific luminosity and 5:2 10 32 cm,2s,1 in multiple bunches demonstrated during the last commissioning period before installation of the BABAR detector. Further luminosity increases are anticipated as the vertical beam size is reduced and beam currents are raised towards design values. At high currents interesting multibunch dynamics, which depend strongly on current distribution, have been observed during single-beam commissioning studies. Transverse beam instabilities nominally controlled using bunch-by-bunch feedback were observed to be significantly suppressed, in the absence of feedback, with beams in collision.
Experience with Multibunch Beam Stability at PEP-II
In this report we discuss high-current, multibunch issues at the PEP-II B factory. To achieve the required beam currents, new techniques are used to help stabilize multibunch beams. In the longitudinal planes of both the low energy (LER) positron ring and the high energy (HER) electron ring, residual phase oscillations are damped with higherorder mode (HOM) absorbers on the accelerating cavities, direct and comb rf loops, a low-frequency ' woofer ' link to correct multibunch modes supported by the cavity, and longitudinal bunch-by-bunch feedback. In the LER residual transverse motion has been successfully damped using transverse multibunch feedback up to the maximum current attained so far of 1.7 A. In the HER however a transverse instability has been observed at unexpectedly low beam currents. In this report we describe diagnostics used and summarize current ' thresholds ' and compare these with expectation. Next we present measurements made in the HER to better understand the apparently low threshold. We also show selected data using short bunch trains. Practical issues associated with very high beam currents are discussed including gap transients and the stabilizing influence of the beam-beam interaction on multibunch beam stability.
SUMOylation disassembles the tetrameric pyruvate kinase M2 to block myeloid differentiation of leukemia cells
Nuclear and unclear functions of SUMO
International audiencePost-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleate cells, including the control of nucleocytoplasmic signalling and transport and the faithful replication of a large and complex genome, as well as the regulation of gene expression