72 research outputs found
Radiative Muon Capture on Hydrogen and the Induced Pseudoscalar Coupling
The first measurement of the elementary process is reported. A photon pair spectrometer was used to measure
the partial branching ratio ( for photons of k >
60 MeV. The value of the weak pseudoscalar coupling constant determined from
the partial branching ratio is , where the first error is the quadrature sum of statistical
and systematic uncertainties and the second error is due to the uncertainty in
, the decay rate of the ortho to para molecule. This
value of g_p is 1.5 times the prediction of PCAC and pion-pole dominance.Comment: 13 pages, RevTeX type, 3 figures (encapsulated postscript), submitted
to Phys. Rev. Let
Bacillus anthracis Lethal Toxin Disrupts TCR Signaling in CD1d-Restricted NKT Cells Leading to Functional Anergy
Exogenous CD1d-binding glycolipid (α-Galactosylceramide, α-GC) stimulates TCR signaling and activation of type-1 natural killer–like T (NKT) cells. Activated NKT cells play a central role in the regulation of adaptive and protective immune responses against pathogens and tumors. In the present study, we tested the effect of Bacillus anthracis lethal toxin (LT) on NKT cells both in vivo and in vitro. LT is a binary toxin known to suppress host immune responses during anthrax disease and intoxicates cells by protective antigen (PA)-mediated intracellular delivery of lethal factor (LF), a potent metalloprotease. We observed that NKT cells expressed anthrax toxin receptors (CMG-2 and TEM-8) and bound more PA than other immune cell types. A sub-lethal dose of LT administered in vivo in C57BL/6 mice decreased expression of the activation receptor NKG2D by NKT cells but not by NK cells. The in vivo administration of LT led to decreased TCR-induced cytokine secretion but did not affect TCR expression. Further analysis revealed LT-dependent inhibition of TCR-stimulated MAP kinase signaling in NKT cells attributable to LT cleavage of the MAP kinase kinase MEK-2. We propose that Bacillus anthracis–derived LT causes a novel form of functional anergy in NKT cells and therefore has potential for contributing to immune evasion by the pathogen
"The post-antibiotic apocalypse" and the "war on superbugs": catastrophe discourse in microbiology, its rhetorical form and political function
Discourses evoking an antibiotic apocalypse and a war on superbugs are emerging just at a time when so-called "catastrophe discourses" are undergoing critical and reflexive scrutiny in the context of global warming and climate change. This article combines insights from social science research into climate change discourses with applied metaphor research based on recent advances in cognitive linguistics, especially with relation to "discourse metaphors." It traces the emergence of a new apocalyptic discourse in microbiology and health care, examines its rhetorical and political function and discusses its advantages and disadvantages. It contains a reply by the author of the central discourse metaphor, "the post-antibiotic apocalypse," examined in the article
Novel 5′TOPmRNAs Regulated by Ribosomal S6 Kinase Are Important for Cardiomyocyte Development: S6 Kinase Suppression Limits Cardiac Differentiation and Promotes Pluripotent Cells Toward a Neural Lineage
Prävalenz nicht-authentischer Beschwerdenbilder und Indikatoren in der Begutachtung psychischer und psychosomatischer Störungen – retrospektive Analyse einer Begutachtungsstichprobe
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