2,265 research outputs found
Asymmetric hyperbolic L-spaces, Heegaard genus, and Dehn filling
An L-space is a rational homology 3-sphere with minimal Heegaard Floer
homology. We give the first examples of hyperbolic L-spaces with no symmetries.
In particular, unlike all previously known L-spaces, these manifolds are not
double branched covers of links in S^3. We prove the existence of infinitely
many such examples (in several distinct families) using a mix of hyperbolic
geometry, Floer theory, and verified computer calculations. Of independent
interest is our technique for using interval arithmetic to certify symmetry
groups and non-existence of isometries of cusped hyperbolic 3-manifolds. In the
process, we give examples of 1-cusped hyperbolic 3-manifolds of Heegaard genus
3 with two distinct lens space fillings. These are the first examples where
multiple Dehn fillings drop the Heegaard genus by more than one, which answers
a question of Gordon.Comment: 19 pages, 2 figures. v2: minor changes to intro. v3: accepted
version, to appear in Math. Res. Letter
A phenobarbital overdose: a case report
Background: Phenobarbital is a long-acting barbiturate,
responsible for many cases of poisoning, from unintentional
overdose or attempted suicide. We report a case of phenobarbital
overdose in a patient with history of depression.
Patients and Methods: A 60 year old woman was admitted to
our Internal Medicine Unit for drowsiness, irritability, difficulties in
the maintenance of an upright position, dysphasia and weakness.
She was suffering from depression and epilepsy and treated with
phenobarbital 150 mg/die.
Results: At the admittance, she had high fever and neck stiffness;
phenobarbital serum levels were 71.2 mcg/ml (3 times u.n.l.);
aminotransferases were 12-17u.n.l. Arterial blood pressure was
80/50 mmHg. An inflammatory meningeal process was excluded
by lumbar puncture; a brain and spinal cord CT scan excluded
spine bone lesions and ischemic stroke. In the suspect of an
overdose, a protocol of urine alkalinization was applied resulting
in a reduction of phenobarbital levels below the therapeutic range
in about 6 days, with state of consciousness, cognitive and
behavioral functions improvement. A rapid normalization in
aminotransferases levels was noted and serology for hepatitis
viruses (HAV, HBV, CMV, EBV, HSV) resulted negative.
Conclusions: In our patient phenobarbital was responsible for
stupor, hypotension, hypertonicity and aminotransferases
elevation, whereas fever was due to a concomitant pulmonary
inflammatory process resolved after antibiotic therapy. Despite the
use of these drugs has been progressively reduced, the number
overdose reports remains still hig
Syntax for free: representing syntax with binding using parametricity
We show that, in a parametric model of polymorphism, the type ∀ α. ((α → α) → α) → (α → α → α) → α is isomorphic to closed de Bruijn terms. That is, the type of closed higher-order abstract syntax terms is isomorphic to a concrete representation. To demonstrate the proof we have constructed a model of parametric polymorphism inside the Coq proof assistant. The proof of the theorem requires parametricity over Kripke relations. We also investigate some variants of this representation
IPOGLICEMIA NEONATALE: RILIEVI EPIDEMIOLOGICI IN UN CAMPIONE DI NEONATI RICOVERATI (2012-2017)
ipoglicemia neonatal
MINT, the molecular interaction database: 2012 update
The Molecular INTeraction Database (MINT, http://mint.bio.uniroma2.it/mint/) is a public repository for protein-protein interactions (PPI) reported in peer-reviewed journals. The database grows steadily over the years and at September 2011 contains approximately 235,000 binary interactions captured from over 4750 publications. The web interface allows the users to search, visualize and download interactions data. MINT is one of the members of the International Molecular Exchange consortium (IMEx) and adopts the Molecular Interaction Ontology of the Proteomics Standard Initiative (PSI-MI) standards for curation and data exchange. MINT data are freely accessible and downloadable at http://mint.bio.uniroma2.it/mint/download.do. We report here the growth of the database, the major changes in curation policy and a new algorithm to assign a confidence to each interaction
On the six-dimensional origin of the AGT correspondence
We argue that the six-dimensional (2,0) superconformal theory defined on M
\times C, with M being a four-manifold and C a Riemann surface, can be twisted
in a way that makes it topological on M and holomorphic on C. Assuming the
existence of such a twisted theory, we show that its chiral algebra contains a
W-algebra when M = R^4, possibly in the presence of a codimension-two defect
operator supported on R^2 \times C \subset M \times C. We expect this structure
to survive the \Omega-deformation.Comment: References added. 14 page
Vertex operators and the geometry of moduli spaces of framed torsion-free sheaves
We define complexes of vector bundles on products of moduli spaces of framed
rank r torsion-free sheaves on the complex projective plane. The top
non-vanishing Chern classes of the cohomology of these complexes yield actions
of the r-colored Heisenberg and Clifford algebras on the equivariant cohomology
of the moduli spaces. In this way we obtain a geometric realization of the
boson-fermion correspondence and related vertex operators.Comment: 36 pages; v2: Definition of geometric Heisenberg operators modified;
v3: Minor typos correcte
The SIMI Gender ‘5 Ws’ Rule for the integration of sex and gender-related variables in clinical studies towards internal medicine equitable research
Biological sex and sociocultural gender matter when it comes to health and diseases. They have been both proposed as the undeniable gateways towards a personalized approach in care delivery. The Gender Working Group of the Italian Society of Internal Medicine (SIMI) was funded in 2019 with the aim of promoting good practice in the integration of sex and gender domains in clinical studies. Starting from a narrative literature review and based on regular meetings which led to a shared virtual discussion during the national SIMI congress in 2021, the members of the WG provided a core operational framework to be applied by internal medicine (IM) specialists to understand and implement their daily activity as researchers and clinicians. The SIMI Gender '5 Ws' Rule for clinical studies has been conceptualized as follows: Who (Clinical Internal Medicine Scientists and Practitioners), What (Gender-related Variables-Gender Core Dataset), Where (Clinical Studies/Translational Research), When (Every Time It Makes Sense) and Why (Explanatory Power of Gender and Opportunities). In particular, the gender core dataset was identified by the following domains (variables to collect accordingly): relations (marital status, social support, discrimination); roles (occupation, caregiver status, household responsibility, primary earner, household dimension); institutionalized gender (education level, personal income, living in rural vs urban areas); and gender identity (validated questionnaires on personality traits). The SIMI Gender '5 Ws' Rule is a simple and easy conceptual framework that will guide IM for the design and analysis of clinical studies
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