Estrogen and neuroprotection: from clinical observations to molecular mechanisms

We now appreciate that estrogen is a pleiotropic gonadal steroid that exerts profound effects on the plasticity and cell survival of the adult brain. Over the past century, the life span of women has increased, but the age of the menopause remains constant. This means that women may now live over one third of their lives in a hypoestrogenic, postmenopausal state. The impact of prolonged hypoestrogenicity on the brain is now a critical health concern as we realize that these women may suffer an increased risk of cognitive dysfunction and neurodegeneration due to a variety of diseases. Accumulating evidence from both clinical and basic science studies indicates that estrogen exerts critical protective actions against neurodegenerative conditions such as Alzheimer's disease and stroke. Here, we review the discoveries that comprise our current understanding of estrogen action against neurodegeneration. These findings carry far-reaching possibilities for improving the quality of life in our aging population

Synchrotron Self-Compton Model for Rapid Nonthermal Flares in Blazars with Frequency-Dependent Time Lags

We model rapid variability of multifrequency emission from blazars occurring across the electromagnetic spectrum (from radio to gamma-rays). Lower energy emission is produced by the synchrotron mechanism, whereas higher energy emission is due to inverse Compton scattering of the synchrotron emission. We take into account energy stratification established by particle acceleration at shock fronts and energy losses due to synchrotron emission. We also consider the effect of light travel delays for the synchrotron emission that supplies the seed photons for inverse Compton scattering. The production of a flare is caused by the collision between a relativistic shock wave and a stationary feature in the jet (e.g., a Mach disk). The collision leads to the formation of forward and reverse shocks, which confine two contiguous emission regions resulting in complex profiles of simulated flares. Simulations of multifrequency flares indicate that relative delays between the inverse Compton flares and their synchrotron counterparts are dominated by energy stratification and geometry of the emitting regions, resulting in both negative and positive time delays depending on the frequency of observation. Light travel effects of the seed photons may lead to a noticeable delay of the inverse Compton emission with respect to synchrotron variability if the line of sight is almost perfectly aligned with the jet. We apply the model to a flare in 3C 273 and derive the properties of shocked plasma responsible for the flare. We show that the pronounced negative time delay between the X-ray and IR light curves (X-rays peak after the maximum in the synchrotron emission) can be accounted for if both forward and reverse shocks are considered.Comment: 48 pages, 18 figures, accepted for publication in The Astrophysical Journa

Geodesic Deviation in Regge Calculus

Geodesic deviation is the most basic manifestation of the influence of gravitational fields on matter. We investigate geodesic deviation within the framework of Regge calculus, and compare the results with the continuous formulation of general relativity on two different levels. We show that the continuum and simplicial descriptions coincide when the cumulative effect of the Regge contributions over an infinitesimal element of area is considered. This comparison provides a quantitative relation between the curvature of the continuous description and the deficit angles of Regge calculus. The results presented might also be of help in developing generic ways of including matter terms in the Regge equations.Comment: 9 pages. Latex 2e with 5 EPS figures. Submitted to CQ

Apparent horizons in simplicial Brill wave initial data

We construct initial data for a particular class of Brill wave metrics using Regge calculus, and compare the results to a corresponding continuum solution, finding excellent agreement. We then search for trapped surfaces in both sets of initial data, and provide an independent verification of the existence of an apparent horizon once a critical gravitational wave amplitude is passed. Our estimate of this critical value, using both the Regge and continuum solutions, supports other recent findings.Comment: 7 pages, 6 EPS figures, LaTeX 2e. Submitted to Class. Quant. Gra

Cauchy-characteristic Evolution of Einstein-Klein-Gordon Systems

A Cauchy-characteristic initial value problem for the Einstein-Klein-Gordon system with spherical symmetry is presented. Initial data are specified on the union of a space-like and null hypersurface. The development of the data is obtained with the combination of a constrained Cauchy evolution in the interior domain and a characteristic evolution in the exterior, asymptotically flat region. The matching interface between the space-like and characteristic foliations is constructed by imposing continuity conditions on metric, extrinsic curvature and scalar field variables, ensuring smoothness across the matching surface. The accuracy of the method is established for all ranges of $M/R$, most notably, with a detailed comparison of invariant observables against reference solutions obtained with a calibrated, global, null algorithm.Comment: Submitted to Phys. Rev. D, 16 pages, revtex, 7 figures available at http://nr.astro.psu.edu:8080/preprints.htm

Topological Lattice Gravity Using Self-Dual Variables

Topological gravity is the reduction of general relativity to flat space-times. A lattice model describing topological gravity is developed starting from a Hamiltonian lattice version of B\w F theory. The extra symmetries not present in gravity that kill the local degrees of freedom in $B\wedge F$ theory are removed. The remaining symmetries preserve the geometrical character of the lattice. Using self-dual variables, the conditions that guarantee the geometricity of the lattice become reality conditions. The local part of the remaining symmetry generators, that respect the geometricity-reality conditions, has the form of Ashtekar's constraints for GR. Only after constraining the initial data to flat lattices and considering the non-local (plus local) part of the constraints does the algebra of the symmetry generators close. A strategy to extend the model for non-flat connections and quantization are discussed.Comment: 22 pages, revtex, no figure

Cauchy-characteristic Evolution of Einstein-Klein-Gordon Systems: The Black Hole Regime

The Cauchy+characteristic matching (CCM) problem for the scalar wave equation is investigated in the background geometry of a Schwarzschild black hole. Previously reported work developed the CCM framework for the coupled Einstein-Klein-Gordon system of equations, assuming a regular center of symmetry. Here, the time evolution after the formation of a black hole is pursued, using a CCM formulation of the governing equations perturbed around the Schwarzschild background. An extension of the matching scheme allows for arbitrary matching boundary motion across the coordinate grid. As a proof of concept, the late time behavior of the dynamics of the scalar field is explored. The power-law tails in both the time-like and null infinity limits are verified.Comment: To appear in Phys. Rev. D, 9 pages, revtex, 5 figures available at http://www.astro.psu.edu/users/nr/preprints.htm

A fully (3+1)-D Regge calculus model of the Kasner cosmology

We describe the first discrete-time 4-dimensional numerical application of Regge calculus. The spacetime is represented as a complex of 4-dimensional simplices, and the geometry interior to each 4-simplex is flat Minkowski spacetime. This simplicial spacetime is constructed so as to be foliated with a one parameter family of spacelike hypersurfaces built of tetrahedra. We implement a novel two-surface initial-data prescription for Regge calculus, and provide the first fully 4-dimensional application of an implicit decoupled evolution scheme (the ``Sorkin evolution scheme''). We benchmark this code on the Kasner cosmology --- a cosmology which embodies generic features of the collapse of many cosmological models. We (1) reproduce the continuum solution with a fractional error in the 3-volume of 10^{-5} after 10000 evolution steps, (2) demonstrate stable evolution, (3) preserve the standard deviation of spatial homogeneity to less than 10^{-10} and (4) explicitly display the existence of diffeomorphism freedom in Regge calculus. We also present the second-order convergence properties of the solution to the continuum.Comment: 22 pages, 5 eps figures, LaTeX. Updated and expanded versio

Reaction mechanism and characteristics of T_{20} in d + ^3He backward elastic scattering at intermediate energies

For backward elastic scattering of deuterons by ^3He, cross sections \sigma and tensor analyzing power T_{20} are measured at E_d=140-270 MeV. The data are analyzed by the PWIA and by the general formula which includes virtual excitations of other channels, with the assumption of the proton transfer from ^3He to the deuteron. Using ^3He wave functions calculated by the Faddeev equation, the PWIA describes global features of the experimental data, while the virtual excitation effects are important for quantitative fits to the T_{20} data. Theoretical predictions on T_{20}, K_y^y (polarization transfer coefficient) and C_{yy} (spin correlation coefficient) are provided up to GeV energies.Comment: REVTEX+epsfig, 17 pages including 6 eps figs, to be published in Phys. Rev.