Anti-Plasmodial activities of some plants extracts used in traditional malaria therapy in Kano-Nigeria

This work was set to evaluate the antiplasmodial activities of some plants used in traditional malaria therapy in Kano State, Nigeria. Nine medicinal plants, distributed into eight families, used for treatment of malaria fever by the Hausa people of Kano-Nigeria were selected based on the traditional claims of the folks. These were collected and extracted using aqueous and organic solvents. A total of nineteen extracts and forty four extract-fractions were obtained. Thirty extracts (7 aqueous extracts, 12 ethanol extracts and 11 methanol extracts-fraction) were selected and screened for their in vitro anti-plasmodial activities against laboratory adapted chloroquine susceptible Plasmodium falciparum strain 3D7. Seven (23.33%) of these extracts that exhibited 70% or more inhibition at 50μg/mL concentration were further evaluated to establish their potency levels. The respective IC50 values obtained ranged between 0.361±0.15μg/ml and 37.67±4.20μg/ml. CALF1 from the leaves of C. aurantifolia (Rutaceae) and CBLF1 (a combination of the leaves of C. aurantifolia, Carica papaya, Mangifera indica and Psidium guajava) were further screened against a clinical isolate of P. falciparum and recorded IC50 values similar to those obtained earlier against the laboratory strain, 12.42±3.94 μg/ml for CBLF1, and 29.69±0.65μg/ml for CALF1 respectively. It could be concluded that majority of the plants have demonstrated appreciable concentration dependent in vitro anti-plasmodial effects against the laboratory adapted and field strains P. falciparum.Keywords: Plants Extracts, Traditional Malaria Therapy, Hausa people, Kano, Nigeri

In vivo anti-malarial potentials of some plants extracts on ICR-mice, Mus musculus

Five medicinal plants, Acacia nilotica (Fabaceae), Citrus aurantifolia (Rutaceae), Mangifera indica (Anacardiaceae) Carica papaya (Caricaceae), and Psidium guajava (Myrtaceae) used for the treatment of malaria/ fever by the Hausa people of Kano-Nigeria were selected based on their traditional claims. These were extracted using ethanol. The in vitro antiplasmodial activities of these extracts against laboratory adapted chloroquine susceptible strain of Plasmodium falciparum (3D7) were earlier reported (Dabo et al. 2013). This study was conducted to evaluate the in vivo antiplasmodial activity of four of these extracts using icr mice in the 4-day suppressive test against P. berghei. The extracts evaluated were: Acacia nilotica (Fabaceae) stem extract coded as ANSF1; Citrus aurantifolia (Rutaceae) leaf extract coded as CALF1; Mangifera indica (Anacardiaceae) leaf extract coded as MILF1 and combination of C. aurantifolia, Carica papaya (Caricaceae), M. indica and Psidium guajava (Myrtaceae) leaves extract coded as CBLF1. CALF1, ANSF1 and CBLF1 (combination) exhibited appreciable degree of suppression of 31.06%, 25.16 and %16.35% respectively. MILF1 did not exhibit any suppression against the P. berghei parasite in vivo at all. With the exception of haemoglobin content (P<0.0363), haematological analysis of the various blood parameters of mice in the control and treated mice indicated no statistical difference (P>0.05). Thus it can be concluded that, the apparent absence of changes in haematological profile alongside activities exhibited by CALF1 (Rutaceae), CBLF1 (a combination) and ANSF1 (Fabaceae),) suggest the bio-availability and antiplasmodial activities of the active substances in the plants evaluated.Keywords: Antimalaria; In vivo, Plants Extracts; Mus musculus; Plasmodium berghei

Determinants of Under-Five Mortality in Builsa District, Upper East Region, Ghana

Under-five mortality rate is an important indicator of a community’s social development. The Upper East region, one of the most poverty-stricken regions in Ghana, has however recorded a dramatic decline in its under-five mortality rate since 1993; from 180 per 1000 live births to 79 per 1000 live births in 2003. The aim was to identify the determinants of under-five mortality in Builsa district. A case-control study was used to collect data from mothers of 60 cases and 120 controls matched for age, sex and place of residence. Even though 70% of mothers were illiter-ate, the educational level of mothers did not influence the child’s risk of death (OR 1.1). Chil-dren of mothers who had had previous child deaths were about 8 times more likely to die (OR 7.45,) while those who had not had vitamin A supplementation were about 10 times more likely to die (OR 9.57). Over 90% of mothers had an insecticide-treated bednet and more than 50% of them exclusively breastfed their children for the first 6 months of life. Protective risk factors identified included: exclusive breastfeeding (OR 0.72), use of an insecticide-treated bednet (OR 0.12), the number of live children a mother had (OR 0.54) and immunization (OR 0.53). Even in poverty, it is possible to improve the child health status of communities. Health staff should be equipped to pay special attention to mothers with previous child deaths in order to assist them to prevent further deaths.Keywords: Under-five mortality, determinants, case-control study, Builsa distric

Technology, Performance, and Market Report of Wind-Diesel Applications for Remote and Island Communities: Preprint

This paper describes the current status of wind-diesel technology and its applications, the current research activities, and the remaining system technical and commercial challenges. System architectures, dispatch strategies, and operating experience from a variety of wind-diesel systems will be discussed, as well as how recent development to explore distributed energy generation solutions for wind generation can benefit from the performance experience of operating systems. The paper also includes a detailed discussion of the performance of wind-diesel applications in Alaska, where 10 wind-diesel stations are operating and additional systems are currently being implemented. Additionally, because this application represents an international opportunity, a community of interest committed to sharing technical and operating developments is being formed. The authors hope to encourage this expansion while allowing communities and nations to investigate the wind-diesel option for reducing their dependence on diesel-driven energy sources