Development and applications of the Gas Electron Multiplier

The Gas Electron Multiplier (GEM) has been recently developed to cope with the severe requirements of high luminosity particle physics experimentation. With excellent position accuracy and very high rate capability, GEM devices are robust and easy to manufacture. The possibility of cascading two or more multipliers permits to achieve larger gains and more stable operation. We discuss major performances of the new detectors, particularly in view of possible use for high rate portal imaging and medical diagnostics

Optimisation of the Gas Electron Multiplier for high rate application

The construction and performance of large size GEM~detectors for the COMPASS~experiment is described. Based on the experience gained during the operation of these detectors in high rate muon, proton, and pion beams we discuss the suitability of their use in harsh radiation environments

Discharge studies and prevention in the gas electron multiplier (GEM)

The gas electron multiplier (GEM) used as single proportional counter or in a cascade of two or more elements, permits to attain high gains and to perform detection and localization of ionizing tracks at very high radiation rates. As in other micro-pattern detectors, however, the occasional occurrence of heavily ionizing trails may trigger a local breakdown, with possible harmful consequences on the device itself and on the readout electronics. This paper describes a systematic investigation of the discharge mechanisms in single and multiple GEM structures, and suggests various strategies to reduce both the energy and the probability of the discharges

Performance of GEM detectors in high intensity particle beams

We describe extensive tests of Double GEM and Triple GEM detectors, including full size prototypes for the COMPASS experiment, exposed to high intensity muon, proton and pion beams at the Paul~Scherrer Institute and at CERN. The measurements aim at detecting problems possible under these operation conditions, the main concern being the occurrence of discharges induced by beam particles. Results on the dependence of the probability for induced discharges on the experimental environment are presented and discussed. Implications for the application of GEM~detectors in experiments at high luminosity colliders are illustrated

On the barrier properties of the cornea: a microscopy study of the penetration of fluorescently labeled nanoparticles, polymers, and sodium fluorescein

Overcoming the natural defensive barrier functions of the eye remains one of the greatest challenges of ocular drug delivery. Cornea is a chemical and mechanical barrier preventing the passage of any foreign bodies including drugs into the eye, but the factors limiting penetration of permeants and nanoparticulate drug delivery systems through the cornea are still not fully understood. In this study, we investigate these barrier properties of the cornea using thiolated and PEGylated (750 and 5000 Da) nanoparticles, sodium fluorescein, and two linear polymers (dextran and polyethylene glycol). Experiments used intact bovine cornea in addition to bovine cornea de-epithelialized or tissues pretreated with cyclodextrin. It was shown that corneal epithelium is the major barrier for permeation; pretreatment of the cornea with β-cyclodextrin provides higher permeation of low molecular weight compounds, such as sodium fluorescein, but does not enhance penetration of nanoparticles and larger molecules. Studying penetration of thiolated and PEGylated (750 and 5000 Da) nanoparticles into the de-epithelialized ocular tissue revealed that interactions between corneal surface and thiol groups of nanoparticles were more significant determinants of penetration than particle size (for the sizes used here). PEGylation with polyethylene glycol of a higher molecular weight (5000 Da) allows penetration of nanoparticles into the stroma, which proceeds gradually, after an initial 1 h lag phase

Thiolated mucoadhesive and PEGylated nonmucoadhesive organosilica nanoparticles from 3-Mercaptopropyltrimethoxysilane

A novel approach has been developed to synthesize thiolated sub-100 nm organosilica nanoparticles from 3-mercaptopropyltrimethoxysilane (MPTS) through its self-condensation in dimethylsulfoxide in contact with atmospheric oxygen. The formation of MPTS nanoparticles proceeds through the condensation of methoxysilane groups and simultaneous disulfide bridging caused by partial oxidation of thiol groups. These nanoparticles showed excellent colloidal stability in dilute aqueous dispersions but underwent further self-assembly into chains and necklaces at higher concentrations. They exhibited very good ability to adhere to ocular mucosal surfaces, which can find applications in drug delivery. The thiolated nanoparticles could also be easily modified through PEGylation resulting in a loss of their mucoadhesive properties