Hierarchical Behavioural Adaptable Design For Testability

National audienc

La mamadie de Neuro-Wilson-A propos de sept cas et revue de la litterature

Description La maladie de Wilson est une toxicose cuprique autosomique récessive dont les manifestations cliniques sont dominées par les signes neuropsychiatriques et hépatiques.Objectif L’objectif de notre travail est de faire le point sur les aspects génétique, diagnostique et thérapeutique du Neuro-Wilson.Méthodes Nous avons procéder à l’étude d’une série de sept cas colligés au service de Neurologie et de Pédiatrie du CHU Hassan II de Fès. Résultats Tous nos patients présentaient des signes neurologiques évocateurs avec ou sans symptôme extra-neurologique. Ils ont eu des examens paracliniques faits de Numération Formule Sanguine, bilan hépatique, bilan rénal, bilan cuprique, imagerie cérébrale, échographie abdominale et fibroscopie digestive haute. Le diagnostic positif de la maladie de Wilson a été retenu devant des arguments cliniques, biologiques et radiologiques. Trois de nos malades ont été mis sous D-pénicillamine et quatre sous sulfate de zinc. L’enquête familiale à la recherche de cas similaires a été réalisée par l’examen clinique de la fratrie de quatre malades de la série.Conclusion Lorsqu’elle n’est pas traitée, l’évolution de la maladie de Wilson est toujours fatale. Le traitement repose sur les chélateurs du cuivre, les sels de zinc et la transplantation hépatique. Le pronostic de la maladie de Wilson apparaît d’autant meilleur que les atteintes neurologique et hépatique sont moins prononcées

Zinc Oxide Nanorods Wrapped with Ion-Imprinted Polypyrrole Polymer for Picomolar Selective and Electrochemical Detection of Mercury II Ions

This study concerns the design of an ion-imprinted polymer (IIP) for the selective detection of mercury II ions. Compared to other electrochemical studies, the originality of this work lies to the fact that the IIP was electropolymerized on ZnO nanorods, which were themselves grown on gold/diazonium modified substrates. This strategy of diazonium salt and ZnO nanorods permits to increase considerably the specific surface and thus to improve the sensor’s performances. The limit of detection (LOD) of the designed sensor was of order of 1 pM, the lowest value ever reported in literature

Design of Novel Electrochemical Sensors for the Selective Detection of Glyphosate

International audienceThis study concerns the development of two molecularly imprinted polymers (MIP) based electrochemical sensors for glyphosate detection. In both cases polypyrrole (PPy) was chosen as matrix and glyphosate molecules were the templates. The main difference between the two strategies is related to the investigated electrode: gold surface in the first case, and ZnO nanorods vertically grown on ITO diazonium modified substrates in the second case. The limits of detection (LOD) of these sensors were about 10−13 M and 10−10 M respectively

Kraft Pulp–Starch Covalent Linking: A Promising Route to a New Material

International audienceWe reported herein, the synthesis process of a direct cross-linking of modified polysaccharides. azidated starch, and alkyne Kraft pulp were cross-linked in the presence of Cu(I) catalyst, a type of Huisgen’s 1,3-dipolar azide–alkyne cycloaddition reaction, leading to the formation of starch cross-linked to kraft pulp fiber. The modified polysaccharides were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and scanning electron microscopy (SEM), and their physical properties were tested. The results show that the obtained novel material’s properties present an important enhancement compared to Kraft pulp fiber, about 71% and 44% for tear and break indexes respectively, up to 173% for elongation and of 136% for burst index