Supporting flight data analysis for Space Shuttle Orbiter experiments at NASA Ames Research Center

The space shuttle orbiter experiments program is responsible for collecting flight data to extend the research and technology base for future aerospace vehicle design. The infrared imagery of shuttle (IRIS), catalytic surface effects, and tile gap heating experiments sponsored by Ames Research Center are part of this program. The software required to process the flight data which support these experiments is described. In addition, data analysis techniques, developed in support of the IRIS experiment, are discussed. Using the flight data base, the techniques provide information useful in analyzing and correcting problems with the experiment, and in interpreting the IRIS image obtained during the entry of the third shuttle mission

Conditions for Capacitor Voltage Regulation in a Five-Level Cascade Multilevel Inverter: Application to Voltage-Boost in a PM Drive

A cascade multilevel inverter is a power electronic device built to synthesize a desired AC voltage from several levels of DC voltages. Such inverters have been the subject of research in the last several years, where the DC levels were considered to be identical in that all of them were either batteries, solar cells, etc. Similar to previous results in the literature, the work here shows how a cascade multilevel inverter can be used to obtain a voltage boost at higher speeds for a three-phase PM drive using only a single DC voltage source. The input of a standard three-leg inverter is connected to the DC source and the output of each leg is fed through an H-bridge (which is supplied by a capacitor) to form a cascade multilevel inverter. A fundamental switching scheme is used, which achieves the fundamental in the output voltage while eliminating the fifth harmonic. A new contribution in this paper is the development of explicit conditions in terms of the power factor and modulation index for which the capacitor voltage of the H-bridges can be regulated while simultaneously maintaining the aforementioned output voltage. This is then used for a PM motor drive showing the machine can attain higher speeds due to the higher output voltage of the multilevel inverter compared to using just a three-leg inverter

High Dynamic Performance Programmed PWM Control of a Multilevel Inverter with Capacitor DC Sources

A cascade multilevel inverter consisting of a standard 3-leg inverter supplied by a DC source and three full H-bridges each supplied by a capacitor is considered for use as a motor drive. The capacitor H-bridges can only supply reactive voltage to the motor while the standard three leg inverter can supply both reactive and active voltage. A switching control algorithm is presented that shows this inverter topology can be used as an AC drive achieving considerable performance advantages (e.g., higher motor speed) compared to using a standard 3-leg inverter while at the same time regulating the capacitor voltages. The converter controller is a fundamental frequency switching controller based on programmed PWM to achieve higher efficiency (less power losses in the switches) compared to high-frequency PWM approaches. As is well known, the programmed PWM switching times are computed assuming the drive is in sinusoidal steady-state, that is, the derived switching angles achieve the fundamental while rejecting specified harmonics if the voltage waveforms are in sinusoidal steady-state. Here it shown that the switching commands to the converter can be implemented in a smooth fashion for voltage waveform commands whose frequency and amplitudes are continuously varying

Reduced Switching-Frequency Active Harmonic Elimination for Multilevel Converters

This paper presents a reduced switching-frequency active-harmonic-elimination method (RAHEM) to eliminate any number of specific order harmonics of multilevel converters. First, resultant theory is applied to transcendental equations to eliminate low-order harmonics and to determine switching angles for a fundamental frequency-switching scheme. Next, based on the number of harmonics to be eliminated, Newton climbing method is applied to transcendental equations to eliminate high-order harmonics and to determine switching angles for the fundamental frequency-switching scheme. Third, the magnitudes and phases of the residual lower order harmonics are computed, generated, and subtracted from the original voltage waveform to eliminate these low-order harmonics. Compared to the active-harmonic-elimination method (AHEM), which generates square waves to cancel high-order harmonics, RAHEM has lower switching frequency. The simulation results show that the method can effectively eliminate all the specific harmonics, and a low total harmonic distortion (THD) near sine wave is produced. An experimental 11-level H-bridge multilevel converter with a field-programmable gate-array controller is employed to experimentally validate the method. The experimental results show that RAHEM does effectively eliminate any number of specific harmonics, and the output voltage waveform has low switching frequency and low THD

DC-AC Cascaded H-Bridge Multilevel Boost Inverter with No Inductors for Electric/Hybrid Electric Vehicle Applications

This paper presents a cascaded H-bridge multilevel boost inverter for electric vehicle (EV) and hybrid EV (HEV) applications implemented without the use of inductors. Currently available power inverter systems for HEVs use a dc–dc boost converter to boost the battery voltage for a traditional three-phase inverter. The present HEV traction drive inverters have low power density, are expensive, and have low efficiency because they need a bulky inductor. A cascaded H-bridge multilevel boost inverter design for EV and HEV applications implemented without the use of inductors is proposed in this paper. Traditionally, each H-bridge needs a dc power supply. The proposed design uses a standard three-leg inverter (one leg for each phase) and an H-bridge in series with each inverter leg which uses a capacitor as the dc power source. A fundamental switching scheme is used to do modulation control and to produce a five-level phase voltage. Experiments show that the proposed dc–ac cascaded H-bridge multilevel boost inverter can output a boosted ac voltage without the use of inductors

Fundamental Frequency Switching Strategies of a Seven-Level Hybrid Cascaded H-Bridge Multilevel Inverter

This paper presents a cascaded H-bridge multilevel inverter that can be implemented using only a single dc power source and capacitors. Standard cascaded multilevel inverters require n dc sources for 2n + 1 levels. Without requiring transformers, the scheme proposed here allows the use of a single dc power source (e.g., a battery or a fuel cell stack) with the remaining n − 1 dc sources being capacitors, which is referred to as hybrid cascaded H-bridge multilevel inverter (HCMLI) in this paper. It is shown that the inverter can simultaneously maintain the dc voltage level of the capacitors and choose a fundamental frequency switching pattern to produce a nearly sinusoidal output. HCMLI using only a single dc source for each phase is promising for high-power motor drive applications as it significantly decreases the number of required dc power supplies, provides high-quality output power due to its high number of output levels, and results in high conversion efficiency and low thermal stress as it uses a fundamental frequency switching scheme. This paper mainly discusses control of seven-level HCMLI with fundamental frequency switching control and how its modulation index range can be extended using triplen harmonic compensation

Distributed Load Balancing in the Presence of Node Failure and Network Delays

In this paper, we present a new dynamic, and adaptive distributed load balancing algorithm. This algorithm is able to handle the loss of some computational nodes, the connectivity of the network, and the variations in tasks and transfer delays. An experimental verification of the algorithm is presented using PlanetLab

Interleukin (IL)-4 Induces Leukocyte Infiltration In Vivo by an Indirect Mechanism

Interleukin (IL)-4 is a cytokine known mainly for its anti-inflammatory activity. Using the in vivo murine air pouch model, we found that IL-4 significantly increased the number of leukocytes after 9 hours of treatment, consisting mainly of neutrophil (60%) and monocytic (40%) cell populations. Using an antibody array, we found that the expression of several analytes (predominantly CCL2) was increased by IL-4 before the arrival of leukocytes. The IL-4-induced expression of CCL-2 was confirmed by ELISA. Air pouch resident lining cells were harvested and were found to express IL-4Rα. CCL2 mRNA expression was monitored in lining cells, cells isolated from the air pouch skin, in RAW264.7 macrophage and in epithelial Mode-K cells and its expression was increased in response to IL-4 in all conditions. We conclude that IL-4 can attract leukocytes in vivo by an indirect mechanism involving the production of several analytes by, at least, resident cells

Dynamic time delay models for load balancing, Part II: A stochastic analysis of the effect of delay uncertainty

In large-scale distributed computing systems, in which the computational elements are physically or virtually distant from each other, there are communication-related delays that can significantly alter the expected performance of load-balancing policies that do not account for such delays. This is a particularly significant problem in systems for which the individual units are connected by means of a shared broadband communication medium (e.g., the Internet, ATM, wireless LAN or wireless Internet). In such cases, the delays, in addition to being large, fluctuate randomly, making their one-time accurate prediction impossible. In this work, the stochastic dynamics of a load-balancing algorithm in a cluster of computer nodes are modeled and used to predict the effects of the random time delays on the algorithm’s performance. A discrete-time stochastic dynamical-equation model is presented describing the evolution of the random queue size of each node. Monte Carlo simulation is also used to demonstrate the extent of the role played by the magnitude and uncertainty of the various time-delay elements in altering the performance of load balancing. This study reveals that the presence of delay (deterministic or random) can lead to a significant degradation in the performance of a load-balancing policy. One way to remedy such a problem is to weaken the load-balancing mechanism so that the load-transfer between nodes is down-scaled (or discouraged) appropriately

Efficacy and Safety of Taspoglutide Versus Sitagliptin for Type 2 Diabetes Mellitus (T-Emerge 4 Trial)

INTRODUCTION: The efficacy and safety of taspoglutide, a long-acting human glucagon-like peptide-1 analog, were compared with sitagliptin or placebo, as adjunct to metformin, in patients with inadequately controlled type 2 diabetes. METHODS: In this randomized, double-blind, double-dummy, parallel-group trial, patients were randomized to taspoglutide 10 mg once weekly (QW), 20 mg QW, 100 mg sitagliptin once daily (QD), or placebo for 24 weeks, followed by 28-week short-term and 104-week long-term extension periods. The primary endpoint was change in glycosylated hemoglobin (HbA(1c)) after 24 weeks. RESULTS: In this study, 666 patients (baseline HbA(1c), 7.96% [SD, 0.87]; fasting plasma glucose, 9.61 mmol/L [2.56]; body weight, 92.4 kg [19.3]) were randomized to taspoglutide 10 mg QW (n = 190), 20 mg QW (n = 198), 100 mg sitagliptin QD (n = 185), or placebo (n = 93) for 24 weeks. After 24 weeks, least squares mean (SE) HbA(1c) reductions were greater with taspoglutide 10 mg (−1.23% [0.06]) and 20 mg (−1.30% [0.06]) versus sitagliptin (−0.89% [0.06]) or placebo (−0.10% [0.08]). Mean treatment differences with taspoglutide 10 mg and 20 mg were −0.34 (95% confidence intervals [CI]: −0.49, −0.19) and −0.41 (−0.56, −0.26) versus sitagliptin; and −1.13 (−1.31, −0.95) and −1.20 (−1.38, −1.02) versus placebo. Weight loss was greater with taspoglutide 10 mg (−1.8 kg [0.3]) and 20 mg (−2.6 kg [0.3]) than sitagliptin (−0.9 kg [0.3]) or placebo (−0.5 kg [0.4]). Effects on HbA(1c) and weight loss continued through 52 weeks of treatment. No cases of severe hypoglycemia occurred with any active treatment. Gastrointestinal adverse events, and allergic and injection-site reactions were higher in the taspoglutide groups, causing higher discontinuation rates. Anti-taspoglutide antibodies were confirmed in 46% of patients. CONCLUSION: Taspoglutide demonstrated better efficacy on glycemic control and weight loss than sitagliptin, but a high incidence of adverse events led to high discontinuation rates. The safety profile of taspoglutide in this trial was similar to other trials in the clinical program, and led to the discontinuation of dosing