Cathodo- and radioluminescence of Tm3+^{3+}:YAG and Nd3+^{3+}:YAG in an extended wavelength range

We have studied the cathodo- and radioluminescence of Nd:YAG and of Tm:YAG single crystals in an extended wavelength range up to $\approx 5\,\mu$m in view of developing a new kind of detector for low-energy, low-rate energy deposition events. Whereas the light yield in the visible range is as large as $\approx 10^{4}\,$photons/MeV, in good agreement with literature results, in the infrared range we have found a light yield $\approx 5\times 10^{4}\,$photons/MeV, thereby proving that ionizing radiation is particularly efficient in populating the low lying levels of rare earth doped crystals.Comment: submitted for publication in Journal of Luminescenc

Polarized thermal emission by thin metal wires

We report new measurements of the linear polarization of thermal radiation emitted by incandescent thin tungsten wires, with thicknesses ranging from five to hundred microns. Our data show very good agreement with theoretical predictions, based on Drude-type fits to measured optical properties of tungsten.Comment: 12 pages, 4 encapsulated figures. This new version matches the one published in New. J. Phys.. Improved presentation, more references added, and one new figure include

Particulate matter exposure shapes DNA methylation through the lifespan

Exposure to airborne particulate matter (PM) has been associated with detrimental health effects. DNA methylation represents the most well-studied epigenetic factor among the possible mechanisms underlying this association. Interestingly, changes of DNA methylation in response to environmental stimuli are being considered for their role in the pathogenic mechanism, but also as mediators of the body adaptation to air pollutants. Several studies have evaluated both global and gene-specific methylation in relation to PM exposure in different clinical conditions and life stages. The purpose of the present literature review is to evaluate the most relevant and recent studies in the field in order to analyze the available evidences on long- and short-term PM exposure and DNA methylation changes, with a particular focus on the different life stages when the alteration occurs. PM exposure modulates DNA methylation affecting several biological mechanisms with marked effects on health, especially during susceptible life stages such as pregnancy, childhood, and the older age. Although many cross-sectional investigations have been conducted so far, only a limited number of prospective studies have explored the potential role of DNA methylation. Future studies are needed in order to evaluate whether these changes might be reverted

A new technique for infrared scintillation measurements

We propose a new technique to measure the infrared scintillation light yield of rare earth (RE) doped crystals by comparing it to near UV-visible scintillation of a calibrated Pr:(Lu$_{0.75}$Y$_{0.25}$)$_{3}$Al$_5$O$_{12}$ sample. As an example, we apply this technique to provide the light yield in visible and infrared range up to \SI{1700}{nm} of this crystal.Comment: submitted to NIM

VALUTAZIONE DI IMPATTO SANITARIO: METODOLOGIA E APPLICAZIONI

The aim of our Ph.D. Research Program was to improve the knowledge and test the implementation in the real world of that combination of procedures, methods and tools defined as Health Impact Assessment (HIA), whose aim is to assess the impact that the construction of industrial plants, infrastructures, housing, transport, energy plants and, broadly, any policy, plan and project in diverse economic sectors may cause on the health of the general population. An HIA procedure was applied to the world exposition \u201cEXPO 2015\u201d (Milan, Italy), focusing on three different phases. The analysis on the PRE-CONSTRUCTION period (ante-operam) allowed us to estimate the effects of exposure to particulate matter with aerodynamic diameter 64 10\ub5m (PM10) and nitrogen dioxide (NO2) on the health of the study population, before the opening of the construction site (2007-2011). The effect estimates were expressed as percent variations in the frequency of expected health events in the population (deaths and hospitalizations) per 10\ub5g/m3 increase in the pollutants concentration. Those estimates (i.e. concentration-response functions, CRF) were obtained by applying Poisson regression models to the daily counts of health events, and were then used to estimate the impact that the exposure to the same pollutants would have entailed during the subsequent CONSTRUCTION phase (January 2013 \u2013 April 2015). The impact was thus quantified in terms of deaths and hospital admissions attributable to the difference between the mean PM10 and NO2 annual concentrations estimated for the study period and the mean PM10 and NO2 annual concentrations corresponding to selected counterfactual scenarios. Our reference scenario was represented by the mean PM10 and NO2 annual concentrations measured by the network of air pollution monitoring stations of the regional environmental protection agency (ARPA Lombardia) in the last year of the PRE-CONTRUCTION phase (2011). In the CONSTRUCTION phase, we estimated 0.54 natural deaths and 0.70 hospitalizations (due to cardiac, cerebrovascular, and respiratory causes) attributable to PM10 levels exceeding the mean concentrations of the PRE-CONSTRUCTION period, in one year. As regards NO2, we estimated 0.36 and 0.56 additional deaths and hospitalizations, respectively. During the second year of the Ph.D. Program the HIA procedure was applied to the EVENT phase (May-October 2015). We obtained estimates of the traffic flow expected during the opening of the exhibition site. Such estimates were then inputted into dispersion models to obtain maps of the ground fallout of PM10 and NO2 emitted by the traffic due to the exhibition. We observed a mild contribution of the EXPO-related traffic flow to the air pollutants concentration averages in the investigated area. The ground fallout levels (annual means) ranged between 0.019 and 0.067\ub5g/m3 for PM10 and between 0.270 and 0.684\ub5g/m3 for NO2. Deaths and hospital admissions data were updated with information from the local health authorities. We were thus able to estimate, on a historical basis, the baseline number of health events we could have expected in our population during the study period. Using the CRFs obtained for the PRE-CONSTRUCTION phase and up-to-date exposure and health data, we estimated, for the EVENT phase, 0.11 natural deaths and 0.15 hospitalizations (due to cardiac, cerebrovascular, and respiratory causes) attributable to PM10 levels exceeding the mean concentrations of the PRE-CONSTRUCTION period, in one year. As regards NO2, we estimated 1.45 and 2.33 additional deaths and hospitalizations, respectively. The HIA methodology was subsequently applied to another study, conducted within the ESSIA project (Effetti Sulla Salute degli Inquinanti Aerodispersi in regione Lombardia: Health Effects of Air Pollutants in Lombardy). The project has been ongoing for several years and quantified the association between air pollutants and population health (effect and impact), based on Lombardy specific characteristics (see Baccini et al., 2011. Am J Epidemiol. 174, 1396-405 and Baccini et al., 2015. Environ Health Perspect. 123, 27-33). The published investigations focused on particulate matter exposure and all-cause mortality, taking into account between-city commuting as well. During the second year of our Ph.D. Program, we expanded the investigated exposures and health events and verified whether the reduction in air pollution levels observed in Lombardy in the last ten years paralleled a decrease in the number of health events. We considered exposure to PM10 and NO2, mortality and hospitalization data for a non-opportunistic sample of the most polluted and densely populated areas of the region (years 2003-2006). We obtained area-specific effect estimates for PM10 and NO2 applying Poisson regression models to the daily count of all-cause deaths and cause-specific hospitalizations (cardiac, cerebrovascular, and respiratory causes). Area-specific estimates were then combined in a random-effect Bayesian meta-analysis. For cardiovascular and respiratory mortality, we applied a case-crossover analysis. Effect estimates were expressed as percent variation of deaths and hospital admissions per 10\ub5g/m3 increase in PM10 or NO2 concentrations. Natural mortality was positively associated with both pollutants (0.30%, 90% Credibility Interval [CrI]: -0.21; 0.70 for PM10; 0.70%, 90%CrI: 0.20; 1.18 for NO2). Cardiovascular deaths were more strongly associated to NO2 (1.12%, 90% Confidence Interval [CI]: 0.30; 1.95), while respiratory mortality was highest in association with PM10 (1.64%, 90%CI: 0.56; 2.72). The effect of both pollutants was more evident in the summer season and a trend in mortality with increasing age classes was apparent for PM10 only. Air pollution was also associated to hospitalizations, the highest variations being 0.77% (90%CrI: 0.31; 1.32) for respiratory diseases and PM10, and 1.70% (90%CrI: 0.60; 2.66) for cerebrovascular diseases and NO2. The effect of PM10 on respiratory hospital admissions increased with age. For both pollutants, effects on cerebrovascular hospitalizations were more evident in subjects aged less than 75 years. In a sub-analysis on all-cause mortality, we evaluated how the mortality burden due to PM10 exposure estimated for the period 2003-2006 (see Baccini et al., 2011. Am J Epidemiol. 174, 1396-405) varied when considering its concentrations in 2014. Assuming our study population and its mortality rates remained constant over time and applying the previously estimated CRFs, we quantified the number of deaths attributable to exposure levels exceeding the threshold of 20\ub5g/m3 for PM10 annual average (WHO Air Quality Guidelines, 2005). The difference between attributable deaths estimated in 2003-2006 and 2014 represents the variation of the mortality burden between the two periods or, in other words, the number of deaths \u201cavoided\u201d thanks to the reduction in PM10 concentrations measured in the last decade. In 2014 we estimated 162 natural deaths less than in the period 2003-2006 (CrI80%: 24.2; 311.6) attributable to PM10 levels exceeding the WHO threshold. As expected, the bigger impact was observed in the capital city of Milan, with a difference between the two periods of 116 deaths due to natural causes (CrI80%: 65; 176)

Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation

Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer, which originates from the mesothelial cells of the pleura and is associated with asbestos exposure. In light of its aggressive nature, late diagnosis and dismal prognosis, there is an urgent need for identification of biomarkers in easily accessible samples (such as blood) for early diagnosis of MPM. In the last 10 years, epigenetic markers, such as DNA methylation and microRNAs (miRNAs), have gained popularity as possible early diagnostic and prognostic biomarkers in cancer research. The aim of this review is to provide a critical analysis of the current evidences on circulating epigenetic biomarkers for MPM and on their translational potential to the clinical practice for early diagnosis and for prognosis

Towards Recommender Systems with Community Detection and Quantum Computing

After decades of being mainly confined to theoretical research, Quantum Computing is now becoming a useful tool for solving realistic problems. This work aims to experimentally explore the feasibility of using currently available quantum computers, based on the Quantum Annealing paradigm, to build a recommender system exploiting community detection. Community detection, by partitioning users and items into densely connected clusters, can boost the accuracy of non-personalized recommendation by assuming that users within each community share similar tastes. However, community detection is a computationally expensive process. The recent availability of Quantum Annealers as cloud-based devices, constitutes a new and promising direction to explore community detection, although effectively leveraging this new technology is a long-term path that still requires advancements in both hardware and algorithms. This work aims to begin this path by assessing the quality of community detection formulated as a Quadratic Unconstrained Binary Optimization problem on a real recommendation scenario. Results on several datasets show that the quantum solver is able to detect communities of comparable quality with respect to classical solvers, but with better speedup, and the non-personalized recommendation models built on top of these communities exhibit improved recommendation quality. The takeaway is that quantum computing, although in its early stages of maturity and applicability, shows promise in its ability to support new recommendation models and to bring improved scalability as technology evolves

Laser induced fluorescence for axion dark matter detection: a feasibility study in YLiF4_4:Er3+^{3+}

We present a detection scheme to search for QCD axion dark matter, that is based on a direct interaction between axions and electrons explicitly predicted by DFSZ axion models. The local axion dark matter field shall drive transitions between Zeeman-split atomic levels separated by the axion rest mass energy $m_a c^2$. Axion-related excitations are then detected with an upconversion scheme involving a pump laser that converts the absorbed axion energy ($\sim$ hundreds of $\mu$eV) to visible or infrared photons, where single photon detection is an established technique. The proposed scheme involves rare-earth ions doped into solid-state crystalline materials, and the optical transitions take place between energy levels of $4f^N$ electron configuration. Beyond discussing theoretical aspects and requirements to achieve a cosmologically relevant sensitivity, especially in terms of spectroscopic material properties, we experimentally investigate backgrounds due to the pump laser at temperatures in the range $1.9-4.2$ K. Our results rule out excitation of the upper Zeeman component of the ground state by laser-related heating effects, and are of some help in optimizing activated material parameters to suppress the multiphonon-assisted Stokes fluorescence.Comment: 8 pages, 5 figure