1 research outputs found
In Vivo Deep Tissue Fluorescence and Magnetic Imaging Employing Hybrid Nanostructures
Breakthroughs in nanotechnology have
made it possible to integrate different nanoparticles in one single
hybrid nanostructure (HNS), constituting multifunctional nanosized
sensors, carriers, and probes with great potential in the life sciences.
In addition, such nanostructures could also offer therapeutic capabilities
to achieve a wider variety of multifunctionalities. In this work,
the encapsulation of both magnetic and infrared emitting nanoparticles
into a polymeric matrix leads to a magnetic-fluorescent HNS with multimodal
magnetic-fluorescent imaging abilities. The magnetic-fluorescent HNS
are capable of simultaneous magnetic resonance imaging and deep tissue
infrared fluorescence imaging, overcoming the tissue penetration limits
of classical visible-light based optical imaging as reported here
in living mice. Additionally, their applicability for magnetic heating
in potential hyperthermia treatments is assessed