Neural adaptations to electrical stimulation strength training

This review provides evidence for the hypothesis that electrostimulation strength training (EST) increases the force of a maximal voluntary contraction (MVC) through neural adaptations in healthy skeletal muscle. Although electrical stimulation and voluntary effort activate muscle differently, there is substantial evidence to suggest that EST modifies the excitability of specific neural paths and such adaptations contribute to the increases in MVC force. Similar to strength training with voluntary contractions, EST increases MVC force after only a few sessions with some changes in muscle biochemistry but without overt muscle hypertrophy. There is some mixed evidence for spinal neural adaptations in the form of an increase in the amplitude of the interpolated twitch and in the amplitude of the volitional wave, with less evidence for changes in spinal excitability. Cross-sectional and exercise studies also suggest that the barrage of sensory and nociceptive inputs acts at the cortical level and can modify the motor cortical output and interhemispheric paths. The data suggest that neural adaptations mediate initial increases in MVC force after short-term EST

The Use of Biomaterials in Islet Transplantation

Pancreatic islet transplantation is a therapeutic option to replace destroyed β cells in autoimmune diabetes. Islets are transplanted into the liver via the portal vein; however, inflammation, the required immunosuppression, and lack of vasculature decrease early islet viability and function. Therefore, the use of accessory therapy and biomaterials to protect islets and improve islet function has definite therapeutic potential. Here we review the application of niche accessory cells and factors, as well as the use of biomaterials as carriers or capsules, for pancreatic islet transplantation

Influence of microenvironment on engraftment of transplanted β-cells

Pancreatic islet transplantation into the liver provides a possibility to treat selected patients with brittle type 1 diabetes mellitus. However, massive early β-cell death increases the number of islets needed to restore glucose homeostasis. Moreover, late dysfunction and death contribute to the poor long-term results of islet transplantation on insulin independence. Studies in recent years have identified early and late challenges for transplanted pancreatic islets, including an instant blood-mediated inflammatory reaction when exposing human islets to the blood microenvironment in the portal vein and the low oxygenated milieu of islets transplanted into the liver. Poor revascularization of remaining intact islets combined with severe changes in the gene expression of islets transplanted into the liver contributes to late dysfunction. Strategies to overcome these hurdles have been developed, and some of these interventions are now even tested in clinical trials providing a hope to improve results in clinical islet transplantation. In parallel, experimental and clinical studies have, based on the identified problems with the liver site, evaluated the possibility of change of implantation organ in order to improve the results. Site-specific differences clearly exist in the engraftment of transplanted islets, and a more thorough characterization of alternative locations is needed. New strategies with modifications of islet microenvironment with cells and growth factors adhered to the islet surface or in a surrounding matrix could be designed to intervene with site-specific hurdles and provide possibilities to improve future results of islet transplantation

Implementing opportunistic spectrum access in LTE-Advanced

Long term evolution advanced (LTE-A) has emerged as a promising mobile broadband access technology aiming to cope with the increasing traffic demand in wireless networks. However, the enhanced spectral efficiency offered by LTE-A may become futile without a better management of scarce and overcrowded electromagnetic spectrum. In this sense, cognitive radio (CR) has been proposed as a potential solution to the problem of spectrum scarcity. Among all the mechanisms provided by CR, opportunistic spectrum access (OSA) aims at a dynamic and seamless use of certain licensed bands provided the licensee is not harmfully affected. This operation requires spectral awareness in order to avoid interferences with licensed systems. In spite of implementing some spectrum sensing mechanisms, LTE-A technology lacks other tools that are needed in order to improve the knowledge of the radio environment. This work studies the adoption of a Geo-located data base (Geo-DB) that cooperatively retrieves and maintains information regarding the location of unutilized portions of spectrum potentially available for OSA. Moreover, the potential benefit of this LTE-compliant OSA solution is evaluated using a calibrated simulation tool, by which numerical results allow us to optimally configure the system and show that the proposed opportunistic system is able to significantly improve its performance.The authors would like to thank the funding received from the Ministerio de Ciencia e Innovacion within the Project number TEC2011-27723-C02-02 and from the Ministerio de Industria, Turismo y Comercio TSI-020100-2011-266 funds. This article had been written in the framework of the CELTIC project CP08-001 COMMUNE. Study by X. Gelabert is funded by the BP-DGR 2010 scholarship (ref. 00192). 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