Non-uniform liquid in external field

To calculate the density profile of a liquid in an external field, it is necessary to consider the density as a functional of the system\u27s chemical potential, i.e. the correlation effects must be investigated. On the basis of a statistical-mechanical calculation, the authors obtained an expansion of the liquid density into a series of moments of correlation functions of different orders. The expression for the liquid density profile was obtained as a sum of local and correlation terms. The correlation term has been calculated within the Ornstein-Zernike approximation in the vicinity of the critical point. It is shown that this term decreases the total variation of density by about 10%

Non-uniform liquid in external field

To calculate the density profile of a liquid in an external field, it is necessary to consider the density as a functional of the system\u27s chemical potential, i.e. the correlation effects must be investigated. On the basis of a statistical-mechanical calculation, the authors obtained an expansion of the liquid density into a series of moments of correlation functions of different orders. The expression for the liquid density profile was obtained as a sum of local and correlation terms. The correlation term has been calculated within the Ornstein-Zernike approximation in the vicinity of the critical point. It is shown that this term decreases the total variation of density by about 10%

Дослідження структурних особливостей взаємодії S-протеїну SARS-CoV-2 з ліпідними мембранами методом малокутового розсіяння нейтронів

The effect of SARS-CoV-2 coronavirus S-protein on the structural parameters of the model lipid membrane on dimyristoylphosphatidylcholine (DMPC) systems with cholesterol and melatonin impurities was studied by the method of small angle neutron scattering. It is shown that an increase in the concentration of melatonin in the lipid membrane leads to a decrease in the thickness of the lipid bilayer, and an increase in the concentration of cholesterol leads to an increase in it. It has been suggested that increasing the concentration of melatonin in the membrane prevents the interaction of coronaviral S-protein with the lipid membrane of the cell. In the presence of cholesterol impurities in the system, the interaction of the lipid membrane with the active part of the S-protein occurs depending on the phase state of the lipid. Thus, when the lipid is in the gel phase (at 10 ° C), the active part of the S-protein does not change the structural parameters of the lipid bilayer, i.e. the interaction between the lipid membrane and the active part of the S-protein does not occur. At 37 ° C, when the lipid is in the liquid crystalline phase, the addition of RBD SARS-CoV-2 in the system DMPC / 30% Cholesterol / D2O leads to a decrease in membrane thickness, indicating the interaction of S-protein with the membrane. Pages of the article in the issue: 127 - 130 Language of the article: UkrainianМетодом малокутового розсіяння нейтронів проведено дослідження впливу S-протеїну коронавірусу SARS-CoV-2 на структурні параметри модельної ліпідної мембрани на системах диміристоїлфосфатидилхоліну (ДМФХ) з домішками холестерину та мелатоніну. Висунуто припущення, що збільшення концентрації мелатоніну в мембрані запобігає взаємодії коронавірусного S-протеїну з ліпідною мембраною клітини. За присутності домішок холестерину в системі взаємодія ліпідної мембрани з активною частиною S-протеїну відбувається залежно від фазового стану ліпіду: у випадку гель-фази взаємодія не відбувається, а у рідкокристалічній фазі додавання RBD SARS-CoV-2 в систему призводить до зменшення товщини мембрани