EVALUATION OF DRUG INFORMATION SERVICES IN PATIENTS WITH DIABETES MELLITUS IN OUTPATIENT INSTALLATIONS GENERAL HOSPITAL PHARMACY COAL REGION

Based on people's unhealthy lifestyle habits and from data on the five biggest diseases for the period July – September 2022 which shows that diabetes mellitus occupies the second level of the five biggest diseases in Batu Bara Hospital, and drug information services are very necessary because there are many patients who still do not understand what to do about drugs, this is done to minimize abuse and interactions between drugs that are not wanted by patients. To find out how drug information services are for DM patients at the Batu Bara Hospital pharmacy installation on an outpatient basis, and to identify the completeness of the information provided by pharmaceutical staff to patients at the Framing Installation at the Batu Bara General Hospital, and also to find out the problems found in technical drug information services provided to patients at the Batu Bara Regional Hospital Pharmacy Installation. This type of research is an observational study. The design of this study is qualitative by making direct observations or observations, interviews and documentation. Drug information services for diabetes mellitus patients in outpatient care at the Batu Bara Hospital pharmacy installation were in the very good category with a result of 96%. Drug information services performed by eight pharmacists consisting of six pharmacists and two pharmacy technicians for outpatient diabetes mellitus patients at the Batu Bara Hospital pharmaceutical installation have met the standards in the very good category with a yield of 96%

TRAINING IN THE PRODUCTION OF ANTI-ACNE CREAM EXTRACTS OF CELERY (APIUM GRAVEOLENS L.) HERBAL EXTRACTS AND COUNSELING ON ITS INHIBITORY TESTS ON BACTERIA GROWTH PROPIONIBACTERIUM ACNES

Herba seledri (Apium graveolens L) merupakan salah satu tanaman obat yang mengandung flavonoid dan tanin yang berperan sebagai antibakteri. Salah satu bakteri penyebab jerawat adalah bakteri Propionibacterium acnes. Pada penelitian ini ekstrak herba seledri diformulasikan dalam bentuk sediaan krim karena krim mudah diaplikasikan. Penelitian ini bertujuan untuk mengetahui apakah ekstrak herba seledri dapat diformulasikan menjadi sediaan krim dan mengetahui aktivitas antibakteri terhadap bakteri Propionibacterium acnes. Penelitian ini menggunakan metode penelitian eksperimental laboratorium, Krim  dibuat dengan konsentrasi 5%, 10%, 15%,  Selanjutnya dilakukan pengujian sifat mutu fisik diantaranya adalah uji organoleptis, uji pH sediaan, uji homogenitas, Uji Daya Sebar dan uji bakteri dengan  propionibacterium acnes dengan menggunakan metode difusi cakram menggunakan kertas cakram. Dengan menggunakan kontrol positif vitacid 0.025% dan kontrol negatif Blanko. Data  yang diperoleh kemudian dianalisis menggunakan uji One way ANOVA satu arah. Hasil penelitian menunjukkan pengujian bahwa sifat fisik mutu sediaan krim memberikan hasil yang baik dan memenuhi syarat sediaan krim.  Hasil uji aktivitas anti bakteri sediaan krim memberikan diameter rata- rata daya hambat sebesar F1 5%, (4,11 mm) lemah pada F2  10% ( 7,16 mm) sedang, dan F3 15% (11,20 mm) kuat. Berdasarkan hasil penelitian yang diperoleh maka dapat disimpulkan bahwa sedian krim antijerawat dengan konsentrasi ekstrak herba seledri 15% mempunyai daya hambat yang paling kuat terhadap bakteri Propionibacterium acne adalah 11,20 mm. Uji SPSS one way Anova menunjukan p <0,05 yang berarti terdapat perbedaan daya hambat pada berbagai konsentrasi ekstrak terhadap pertumbuhan bakteri Propionibacterium acnes penyebab jerawat

ACTIVITY TEST ETHANOL EXTRACT MATOA (POMETIA PINNATA) ANTINFLAMMATION AGAINST MALE RATS INDUCED CARAGENAN

Matoa merupakan salah satu tanaman dari famili Sapindaceae yang tersebar di daerah tropis, termasuk Indonesia. Tanaman matoa banyak digunakan masyarakat dalam pengobatan tradisional. Penelitian ini dilakukan dengan tujuan untuk mengetahui efek antiinflamasi ekstrak etanol daun matoa (Pometia pinnata) terhadap mencit putih jantan yang di induksi karagenan. Penelitian ini adalah penelitian eksperimental yang dibagi menjadi 5 kelompok yaitu kontrol positif (Natrium Diklofenak 6,5 mg/kgBB), kontrol negatif (Na-CMC 0,5%) dan tiga dosis yang diuji yaitu 100 mg/kgBB, 200 mg/kgBB dan 300 mg/kgBB. Metode dalam penelitian ini adalah dengan induksi karagenan 0,1 ml sebagai iritan pada telapak kaki mencit selama 360 menit dengan parameter yang diamati adalah penghambatan udem kaki mencit menggunakan pletismometer. Hasil penelitian ini menunjukkan adanya perbedaan yang signifikan (P>0,05) dengan kesimpulan tiga dosis yang diuji yaitu 100 mg/kgBB, 200 mg/kgBB dan 300 mg/kgBB memiliki efek antiinflamasi dimana dosis yang lebih efektif adalah 300 mg/kgBB

Seminar on Implementation of Pharmaceutical Service Standards During the Covid-19 Pandemic at Granmed Lubuk Pakam Hospital at 2020

Pharmacist pharmaceutical services for patients related to pharmaceutical preparations in order to improve the quality of pharmaceutical services in hospitals, the implementation of the Minister of Health Regulation no. 72 of 2016 concerning pharmaceutical service standards at Grandmed Hospitals with patient satisfaction during the Covid 19 2021 pandemic. Hospital pharmacy services involve pharmacists in order to supervise and control all activities related to healing treatment of sufferers in the aim of practicing patient safety standards which include Pharmaceutical supplies management activities starting from demand planning to controlling pharmaceutical supplies as well as clinical pharmacy service activities that are oriented towards reducing the risk of drug use errors in hospitals. This type of design was made by collecting data from 59 visiting patients at a certain point in time. Location at GrandMed Hospital Lubuk Pakam. The data obtained were compared with existing standards in the literature and analyzed using the chi-square test. It is known that out of 25 people (42.4%) respondents stated that clinical pharmacy services were not good. Of the 34 people (57.6%) respondents who stated that clinical pharmacy services were good for each employee, they had been given an understanding regarding clinical pharmacy services which had been socialized every morning briefing to maximize serving patients so that patients were satisfied with the services at Grandmed Hospital. This study can be concluded that the implementation of pmk no. 72 of 2016 there is a relationship between clinical pharmacy services and patient satisfaction during the Covid 19 pandemic at Grandmed Lubuk Pakam Hospital in 2021 (pvalue = 0.007)

Socialization of Rhodamine B Dye Content in Liptint Sold in Lubuk Pakam Which is Analyzed Using UV-Vis Spectrophotometry

Rhodamine B is a synthetic dye that is always used to color paper, textiles or ink. The use of rhodamine B is very unsafe for physical fitness and health. When applied without an agent in the body, Rhodamine B irritates the respiratory tract and can cause cancer and liver damage. Even though it has negative effects, this dye is still widely used by irresponsible individuals to make a profit, especially in food processing and cosmetics. Objective: This community service is carried out with the aim of educating the public about the dangers of rhodamine for our bodies, as well as finding out the Rhodamine B content in lipsticks distributed in Lubuk Pakam, where lipstick is one of the cosmetics most widely used by the public, especially women. Method: The method used is socialization by providing direct outreach to the community, especially to mothers and teenagers about the dyes in lip tint which refer to the research results. Qualitative analysis of rhodamine B was carried out using TLC with the mobile phases of ethyl acetate, methanol and ammonia (45 :25:30), while quantitative analysis was carried out in the determination using UV-VIS spectrophotometry at 545 nm. The strategy used in providing knowledge about the dangers of dyes in cosmetics is by giving direct lectures about the various kinds of dyes used in cosmetics, the potential dangers that will arise if cosmetics with excessive dyes are used along with the characteristics of cosmetics with dyes and It is hoped that the public can avoid cosmetics that are indicated to use dyes and get safe cosmetic solutions using natural dyes

WORKSHOP OF FORMULATION LIQUID SOAP FROM CELERY (Apium graveolens L) LEAF EXTRACT TO MOISTURIZING SKIN

Kerusakan kulit umumnya terjadi pada lapisan stratum korneum atau memiliki nama lain barrier yaitu lapisan kulit terluar yang memiliki pertahanan pertama dalam menghalangi dan sinar UV yang masuk ke lapisan kulit. Tujuan dari kegiatan seminar ini untuk mensosialisasikan ekstrak daun seledri dengan konsentrasi 10%, 15%, dan 20% dapat melembabkan kulit. Metode pemuatan sediaan dilakukan dengan pemeriksaan organoleptik, homogenitas, uji iritasi, uji tinggi busa dan uji kelembapan pada sediaan sabun cair dari ekstrak daun seledri. Hasil yang didapatkan dari Uji kelembapan sabun cair yang mengandung ekstrak daun seledri berfungsi untuk melembabkan kulit pada konsentrasi 20%. Kesimpulan: Ekstrak daun seledri dapat diformulasikan dalam sediaan sabun cair untuk melembabkan kulit 61,1% pada konsentrasi 20% semakin tinggi konsentrasi maka semakin lembab kulit

ANTIBACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT OF MANILA SAWO LEAVES (MANILKARA ZAPOTA) AGAINST BACTERIA STREPTOCOCCUS MUTANS)

Daun sawo manila merupakan salah satu tanaman yang dapat digunakan sebagai obat tradisional. Daun sawo manila mengandung senyawa metabolit sekunder flavonoid, fenolik, tanin, saponin, yang bersifat sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri pada ekstrak daun sawo manila (Manilkara zapota) terhadap bakteri Streptoccocus mutans. Penelitian ini merupakan penelitian eksperimental laboratorium. Sampel yang digunakan diperoleh dari daun sawo diekstraksi dengan metode maserasi menggunakan pelarut etanol. Metode yang digunakan dalam uji daya hambat antibakteri menggunakan difusi cakram dengan 6 kelompok perlakuan yang terdiri dari konsentrasi 50%, 60%, 70%, 80%, serta Amoxicillin sebagai kontrol positif dan DMSO sebagai kontrol negatif diulang sebanyak 4 kali pengulangan. Parameter yang diamati adalah diameter zona hambat pertumbuhan bakteri Streptococcus mutans. Analisis data menggunakan One way-ANOVA. Hasil penelitian menunjukkan ekstrak etanol daun sawo manila memiliki kemampuan daya hambat antibakteri pada konsentrasi 50% (15,85 mm), 60% (16,45 mm), 70% (17,05 mm), 80% (17,45 mm). Kesimpulan dari penelitian ini membuktikan bahwa ekstrak etanol daun sawo manila memiliki aktivitas daya hambat antibakteri terhadap bakteri Streptococcus mutans

SEMINAR TENTANG PELEMBAB KULIT WAJAH DARI EKSTRAK DAUN NANGKA (ATROCARPUS HETEROPHYLLUS LAM.)

One of the Indonesia plant has the potential to produce a natural antioxidannt is nangka leaf containing flavonoids,saponins, tannins.objectives: tomake preparations creamy nangka leaf extract mask. Method the study was conducted experimentally,the sampelwas extracted by maceration for 3x24 hours using 96% ethanol. The results of the viscous extract is obtained as the active substances with concentrations 5% and 10%. Test preparations test organoleptis, include an examination of its homogeneity, ph preparations and skin moisture. Homogeneity test showed that the mask cream preparations produced were homogeneous, pH range 6-7 and the humidity test with a concentration of 5% obtained an average value and could moisturize the skin and a concentration of 10% obtained an average value of 59.46% could moisturize the skin. Jackfruit leaf extract can be formulated in cream mask preparations and cream jackfruit leaf mask extract preparations can moisturize the skin

UJI AKTIVITAS EKSTRAK ETANOL DAUN LABU SIAM (SECHIUM EDULE (JACQ.) SWARTZ) TERHADAP AKTIVITAS ANTIBAKTERI STAPHYLOCOCCUS AUREUS

Labu siam merupakan tumbuhan jenis labu-labuan yang dapat dimakan buah dan pucuk mudanya. Tumbuhan labu siam mengandung senyawa metabolit sekunder antara flavonoid, alkaloid, saponin. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun labu siam (Sechium edele (Jacq.) Swartz) terhadap pertumbuhan bakteri Staphylococcus aureus. Penelitian ini dilakukan dengan menggunakan metode eksperimental murni. Metode yang digunakan dalam uji aktivitas antibakteri adalah metode difusi dengan kertas cakram. Konsentrasi yang digunakan pada ekstrak daun labu siam terdiri dari konsentrasi 20%, 40%,dan 60%. Hasil skrining fitokimia menunjukkan bahwa ekstak daun labu siam mengandung saponin, flavonoid, dan tanin. Pengaruh pemberian ekstrak daun labu siam terhadap Staphylococcus aureus ditandai dengan terbentuknya zona hambat pada konsentrasi 20%, 40%, dan 60% secara berurutan dengan rerata diameter sebesar 6,6 mm; 8,5 mm; 10,3 mm. Hasil uji One-Way ANOVA didapatkan nilai sig 0,000 (sig<0,05) dan berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat pengaruh konsentrasi ekstrak daun labu siam terhadap pertumbuhan bakteri Staphylococcus aureus. Konsentrasi 60% yang paling efektif dalam menghambat pertumbuhan bakteri dengan potensi kuat dalam menghambat pertumbuhan bakteri Staphylococcus aureus dengan mengunakan metode difusi. Disarankan pada peneliti selanjutnya untuk melakukan uji aktivitas antibakteri pada bagian tumbuhan yang lain seperti bunga, batang dan akar

FORMULATION AND TEST INHIBITORY EFFECT OF MUSHROOMS CREAM PREPARATION ETHANOL EXTRACT AVOCADO SEEDS (PERSEA AMERICANA MILL) AGAINST MALASSEZIA FURFUR IN VITRO

Avocado seeds (Persea americana Mill) are household waste that contains secondary metabolites that can be used as antifungal agents. The antifungal activity of pure ethanol extract from avocado seeds (Persea americana Mill) has been tested and shown to have inhibitory effects on the fungus Malassezia furfur. Pityriasis versicolor is one of the diseases that can be treated due to the infection of Malassezia furfur, and skin diseases are generally treated using semi-solid formulations like creams. The objective of this study is to determine the antifungal activity of a cream formulation of ethanol extract from avocado seeds against Malassezia furfur. The method used to test the inhibitory activity of the cream containing ethanol extract from avocado seeds (Persea americana Mill) against Malassezia furfur is the disc diffusion method. Phytochemical screening results indicated that the ethanol extract from avocado seeds contains alkaloids, flavonoids, tannins, and saponins. The cream containing ethanol extract from avocado seeds (Persea americana Mill) was tested at concentrations of 20% (10 grams), 40% (20 grams), and 60% (30 grams), along with a positive control of Ketoconazole 2%. The research results showed that the cream containing ethanol extract from avocado seeds (Persea americana Mill) at concentrations of 20%, 40%, and 60% exhibited inhibitory zones with diameters of 5.85 mm, 6.73 mm, and 7.66 mm, categorizing them as having a moderate inhibitory effect. Therefore, it can be concluded that the greater the concentration of the extract, the larger the diameter of the inhibitory zone." Keywords: Panu, Malassezia furfur, Antifungal, Cream, Avocado seed (Persea americana Mill)