Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD

Background: Lack of awareness of cognitive decline (ACD) is common in late-stage Alzheimer’s disease (AD). Recent studies showed that ACD can also be reduced in the early stages. Methods: We described different trends of evolution of ACD over 3 years in a cohort of memory-complainers and their association to amyloid burden and brain metabolism. We studied the impact of ACD at baseline on cognitive scores’ evolution and the association between longitudinal changes in ACD and in cognitive score. Results: 76.8% of subjects constantly had an accurate ACD (reference class). 18.95% showed a steadily heightened ACD and were comparable to those with accurate ACD in terms of demographic characteristics and AD biomarkers. 4.25% constantly showed low ACD, had significantly higher amyloid burden than the reference class, and were mostly men. We found no overall effect of baseline ACD on cognitive scores’ evolution and no association between longitudinal changes in ACD and in cognitive scores. Conclusions: ACD begins to decrease during the preclinical phase in a group of individuals, who are of great interest and need to be further characterized. Trial registration: The present study was conducted as part of the INSIGHT-PreAD study. The identification number of INSIGHT-PreAD study (ID-RCB) is 2012-A01731-42

Low Cognitive Awareness, but Not Complaint, is a Good Marker of Preclinical Alzheimer's Disease

Subjective cognitive decline (SCD) may result from many conditions, including Alzheimer's disease (AD)

NMR STUDY OF ELECTRON SPIN FLUCTUATIONS IN INTERMEDIATE VALENT AND HEAVY FERMION SYSTEMS

Spin fluctuations have been studied by NMR in several cerium, ytterbium and uranium compounds exhibiting intermediate valent, Kondo or heavy fermion properties. From this study a universal thermal dependence of the f electron spin fluctuation rate emerges, at least in the 4f systems. The results are discussed by comparison with a numerical calculation by Cox in the Anderson's model and exact Bethe Ansatz results

Surface dependence of the magnetic configurations of the ordered B2 FeCr alloy

Tight-binding linear muffin tin orbitals calculations with generalized gradient approximation were carried out for the magnetic configurations at the surface of the ferromagnetic ordered B2 FeCr alloys. For both (001) and (111) crystallographic phases, non ferromagnetic configurations are shown to be more stable than the ferromagnetic configuration of the bulk alloy. For (001) surface we display a c$(2\times2)$ ground state for either Cr or Fe at the surface. For Cr top layer the magnetic moments are $700\%$ larger than in the bulk B2 FeCr while they are slightly enhanced for Fe top layer. For (111) surface an antiferromagnetic coupling between surface and subsurface is always obtained i.e. for either Fe or Cr at the surface. This change of coupling between Fe and Cr (from ferromagnetic to antiferromagnetic) is expected to be fundamental to any explanation of the experimental results obtained for the interface alloying at the Fe/Cr interfaces

Ab initio study of the magnetic configurations on the (0 0 1) surfaces of binary FePd and FeRh ordered alloys

Ab initio calculations of the local spin polarization at the (0 0 1) surfaces performed on the binary FePd and FeRh alloys are presented. For Rh-terminated FeRh (0 0 1) surface, the calculations indicate a possible magnetic reconstruction leading to a ferromagnetic order in the surface region, in contrast to the AF-II ground state of the infinite bulk FeRh alloy

Magnetic reconstructions at the surface of the B2 FeV alloy

Abstract. We present an ab initio study of the magnetic surface reconstructions of the B2 FeV alloy using a self-consistent tight-binding linearized muffin tin orbital method developed in the atomic spheres approximation. For (001) and (111), the surface reconstruction stabilizes configurations unstable in the bulk alloy. When Fe is at the (001) surface, a c(2 × 2) in-plane antiferromagnetic order is found to be the ground state with magnetic moments of −2.32µB and 2.27µB. Ap(1 × 1) ↓ ferromagnetic order is displayed in case of V toplayer with a magnetic moment of −1.83µB. At the (111) surface, we obtain for Fe toplayer two solutions p(1 × 1) ↑ and p(2 × 1). The configuration p(1×1) ↑ is found to be the ground state with a magnetic moment per atom of 2.34µB. For V toplayer, only the p(1 × 1) ↓ solution is obtained with a moment of −0.84µB. In all cases, the Fe-V coupling is always antiparallel like in the bulk. Our results are discussed and compared to experiments. PACS. 75.70.Rf Surface magnetism – 73.20.-r Electron states at surfaces and interfaces – 71.20.Be Transition metals and alloys