Velocities from Cross-Correlation: A Guide for Self-Improvement

The measurement of Doppler velocity shifts in spectra is a ubiquitous theme in astronomy, usually handled by computing the cross-correlation of the signals, and finding the location of its maximum. This paper addresses the problem of the determination of wavelength or velocity shifts among multiple spectra of the same, or very similar, objects. We implement the classical cross-correlation method and experiment with several simple models to determine the location of the maximum of the cross-correlation function. We propose a new technique, 'self-improvement', to refine the derived solutions by requiring that the relative velocity for any given pair of spectra is consistent with all others. By exploiting all available information, spectroscopic surveys involving large numbers of similar objects may improve their precision significantly. As an example, we simulate the analysis of a survey of G-type stars with the SDSS instrumentation. Applying 'self-improvement' refines relative radial velocities by more than 50% at low signal-to-noise ratio. The concept is equally applicable to the problem of combining a series of spectroscopic observations of the same object, each with a different Doppler velocity or instrument-related offset, into a single spectrum with an enhanced signal-to-noise ratio.Comment: 7 pages, 3 figures, uses emulateapj.cls; to appear in the Astronomical Journal; see http://hebe.as.utexas.edu/stools/ to obtain the companion softwar

A Wire Position Monitor System for the 1.3 GHZ Tesla-Style Cryomodule at the Fermilab New-Muon-Lab Accelerator

The first cryomodule for the beam test facility at the Fermilab New-Muon-Lab building is currently under RF commissioning. Among other diagnostics systems, the transverse position of the helium gas return pipe with the connected 1.3 GHz SRF accelerating cavities is measured along the ~15 m long module using a stretched-wire position monitoring system. An overview of the wire position monitor system technology is given, along with preliminary results taken at the initial module cool down, and during further testing. As the measurement system offers a high resolution, we also discuss options for use as a vibration detector.Comment: 4 pp. 15th International Conference on RF Superconductivity (SRF2011). 25-29 Jul 2011. Chicago, Illinois, US

Variable stars in the globular cluster M28 (NGC 6626)

We present a new search for variable stars in the Galactic globular cluster M28 (NGC 6626). The search is based on a series of BVI images obtained with the SMARTS Consortium's 1.3m telescope at Cerro Tololo Inter-American Observatory, Chile. The search was carried out using the ISIS v2.2 image subtraction package. We find a total of 25 variable stars in the field of the cluster, 9 being new discoveries. Of the newly found variables, 1 is an ab-type RR Lyrae star, 6 are c-type RR Lyrae, and 2 are long-period/semi-regular variables. V22, previously classified as a type II Cepheid, appears as a bona-fide RRc in our data. In turn, V20, previously classified as an ab-type RR Lyrae, could not be properly phased with any reasonable period. The properties of the ab-type RR Lyrae stars in M28 appear most consistent with an Oosterhoff-intermediate classification, which is unusual for bona-fide Galactic globulars clusters. However, the cluster's c-type variables do not clearly support such an Oosterhoff type, and a hybrid Oosterhoff I/II system is accordingly another possibility, thus raising the intriguing possibility of multiple populations being present in M28. Coordinates, periods, and light curves in differential fluxes are provided for all the detected variables.Comment: A&A, in pres

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone

Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1 expression but relies in the generation of reactive oxygen species (ROS), which are actively scavenged in cells with NRF2/KEAP1 mutations. However, whether NRF2/KEAP1 mutations influence the response to β-lapachone treatment remains unknown. To address this question, we assessed the cytotoxicity of β-lapachone in a panel of NSCLC cell lines bearing either wild-type or mutant KEAP1. We found that, despite overexpression of NQO1, KEAP1 mutant cells were resistant to β-lapachone due to enhanced detoxification of ROS, which prevented DNA damage and cell death. To evaluate whether specific inhibition of the NRF2-regulated antioxidant enzymes could abrogate resistance to β-lapachone, we systematically inhibited the four major antioxidant cellular systems using genetic and/or pharmacologic approaches. We demonstrated that inhibition of the thioredoxin-dependent system or copper-zinc superoxide dismutase (SOD1) could abrogate NRF2-mediated resistance to β-lapachone, while depletion of catalase or glutathione was ineffective. Interestingly, inhibition of SOD1 selectively sensitized KEAP1 mutant cells to β-lapachone exposure. Our results suggest that NRF2/KEAP1 mutational status might serve as a predictive biomarker for response to NQO1-bioactivatable quinones in patients. Further, our results suggest SOD1 inhibition may have potential utility in combination with other ROS inducers in patients with KEAP1/NRF2 mutations

Searching for Planets in the Hyades V: Limits on Planet Detection in the Presence of Stellar Activity

We present the results of a radial velocity survey of a sample of Hyades stars, and discuss the effects of stellar activity on radial velocity measurements. The level of radial velocity scatter due to rotational modulation of stellar surface features for the Hyades is in agreement with the predictions of Saar & Donahue (1997)- the maximum radial velocity rms of up to ~50 m/s, with an average rms of ~16 m/s. In this sample of 94 stars, we find 1 new binary, 2 stars with linear trends indicative of binary companions, and no close-in giant planets. We discuss the limits on extrasolar planet detection in the Hyades and the constraints imposed on radial velocity surveys of young stars.Comment: To appear in the June 2004 issue of A

Nesting Induced Peierls-type Instability for Compressed Li-CI16

Alkalies are considered to be simple metals at ambient conditions. However, recently reported theoretical and experimental results have shown an unexpected and intriguing correlation between complex structures and an enhanced superconducting transition temperature in lithium under pressure. In this article we analyze the pressure induced Fermi surface deformation in bcc lithium, and its relation to the observed cI16 structure. According to our calculations, the Fermi surface becomes increasingly anisotropic with pressure and develops an extended nesting along the bcc [121] direction. This nesting induces a phonon instability of both transverse modes at N, so that a Peierls-type mechanism is proposed to explain the stability of Li-cI16.Comment: Proceedings of Fukuoka 2006 Conference on Novel Pressure-induced Phenomena in Condensed Matter Systems. To be published in J. Phys. Soc. Jpn. 2 pages and 3 figure

CLIWOC multilingual meteorological dictionary

This dictionary is the first attempt to express the wealth of archaic logbook wind force terms in a form that is comprehensible to the modern-day reader. Oliver and Kington (1970) and Lamb (1982) have drawn attention to the importance of logbooks in climatic studies, and Lamb (1991) offered a conversion scale for early eighteenth century English wind force terms, but no studies have thus far pursued the matter to any greater depth. This text attempts to make good this deficiency, and is derived from the research undertaken by the CLIWOC project1 in which British, Dutch, French and Spanish naval and merchant logbooks from the period 1750 to 1850 were used to derive a global database of climatic information. At an early stage in the project it was apparent that many of the logbook weather terms, whilst conforming to a conventional vocabulary, possessed meanings that were unclear to twenty-first century readers or had changed over time. This was particularly the case for the important element of wind force; but no special plea is entered for the evolution in nautical vocabulary, which often reflected more wide-ranging changes in the respective native languages.The key objective was to translate the archaic vocabulary of the late eighteenth and early nineteenth century mariner into expressions directly comparable with the Beaufort Scale (see Appendix I). Only then could the projects scientific programme be embarked upon. This dictionary is the result of the largest undertaking into logbook studies that has yet been carried out. Several thousand logbooks from British, Dutch, French and Spanish archives were examined, and the exercise offered a unique opportunity to explore the vocabulary of the one hundred year period beginning in 1750. The logbooks from which the raw data have been abstracted range widely across the North and South Atlantic and the Indian Oceans. Only the Pacific, largely in consequence of the paucity of regular naval activity in that area, is not well represented. The range of climates encountered in this otherwise wide geographic domain gives ample opportunity for the full range of the mariners nautical weather vocabulary to be assessed, from the calms of the Equatorial regions, through the gales of the mid-latitude systems to the fearsome storms of the tropical latitudes. The Trade Winds belts, the Doldrums, the unsettled mid-latitudes, even the icy wastes of the high latitudes, are all embraced in this study. It is not here intended to pass any judgements on the climatological record of the logbooks, and this text seeks only to provide a means of understanding archaic wind force terms and, other than to indicate those items that were not commonly used, no information is given on the frequency with which different terms appeared in the logbooks. Attention is, furthermore, confined to Dutch, English, French and Spanish because these once great imperial powers were the only nations able to support wide-ranging ocean-going fleets with their attendant collections of logbooks and documents over this long period of time. The work is offered to the wider academic community in the hope that they will prove to be of as much value as it has been to the CLIWOC team