Correlation between broiler lameness and anatomical measurements of bone using radiographical projections with assessments of consistency across and within radiographs

Lameness represents a major welfare and production issue in the poultry industry with a recent survey estimating 27% of birds lame and 3% unable to walk by 40 d of age. A variety of factors may induce lameness and are typically grouped into 2 broad classes on the basis of being infectious or skeletal in nature with the latter accounting for the majority of cases. The current work sought to build upon a large body of literature assessing the anatomical properties of bone in lame birds. Our specific objectives sought to identify relationships between relevant anatomical properties of the tibia and metatarsus using digital quantification from radiographs of legs and a measure of walking difficulty. Resulting output was statistically analyzed to assess 1) observer reliability for consistency in placing the leg during the radiograph procedure and quantification of the various measures within a radiograph, 2) the relationship between the various measurements of anatomical bone properties and sex, bird mass, and gait score, and 3) the relationship between each measurement and leg symmetry. Our anatomical bone measures were found to be reliable (intra-rater and test-retest reliabilities < 0.75) within radiograph for all measures and 8 of the 10 measures across radiographs. Several measures of bone properties in the tibia correlated to difficulty walking as measured by gait score (P < 0.05), indicating greater angulations with increasing lameness. Of the measures that manifested a gait score × bird mass interaction, heavier birds appeared to exhibit less angulation with increasing difficulty walking with lighter birds the opposite. These interactions suggest possibilities for influencing effects of activity or feed intake on bone mineralization with the bone angulation observed. Our efforts agree with that of others and indicate that angulation of the tibia may be related to lameness, though subsequent efforts involving comprehensive measures of bird activity, growth rates, and internal bone structure will be needed if the validity of the measures are to be accepte

Gaugino condensation in an improved heterotic M-theory

Gaugino condensation is discussed in the context of a consistent new version of low energy heterotic M-theory. The four dimensional reduction of the theory is described, based on simple boson and fermion backgrounds. This is generalised to include gaugino condenstates and various background fluxes, some with non-trivial topology. It is found that condensate and quantised flux contributions to the four-dimensional superpotential contain no corrections due to the warping of the higher dimensional metric.Comment: 11 pages, 4 figures, LaTe

Quantum optical coherence tomography of a biological sample

Quantum optical coherence tomography (QOCT) makes use of an entangled-photon light source to carry out dispersion-immune axial optical sectioning. We present the first experimental QOCT images of a biological sample: an onion-skin tissue coated with gold nanoparticles. 3D images are presented in the form of 2D sections of different orientations.Comment: 16 Pages, 6 Figure

Job Stress and Work Ability Among Emergency Nurses in Isfahan, Iran

Background: Job stress is one of the most common health problems with clinical and psychological consequences, which can affect work ability among emergency nurses. Nevertheless, more studies are needed to shed light on the status of this disorder and its relevance to work ability in nurses in the emergency departments (EDs). Objectives: The current study aimed to determine job stress among emergency nurses and its association with work ability. Methods: This cross-sectional study was conducted in 2013 in hospitals affiliated to Isfahan University of Medical Sciences, Isfahan, Iran. Two hundred nurses who worked in the EDs were asked to complete a demographic questionnaire and special scales to assess their job stress and work ability. T-tests, analysis of variance, Pearson correlation coefficient and linear regression were used to analyze the data. Results: The mean job stress and work ability scores were 151.09 ± 0.01 and 26.9 ± 8.2, respectively. Fifty-five percent of the subjects had high job stress and fifty-seven percent showed low work ability. A significant indirect correlation was found between job stress and work ability scores in the subjects (P = 0.015). Conclusions: Nurses working in the EDs experience a high level of job stress and low work ability. This may decrease the quality of care and patients’ safety. Fulfilling the staff shortage in ED and improving management behaviors are important in this regard

Scalable Similarity Search for Molecular Descriptors

Similarity search over chemical compound databases is a fundamental task in the discovery and design of novel drug-like molecules. Such databases often encode molecules as non-negative integer vectors, called molecular descriptors, which represent rich information on various molecular properties. While there exist efficient indexing structures for searching databases of binary vectors, solutions for more general integer vectors are in their infancy. In this paper we present a time- and space- efficient index for the problem that we call the succinct intervals-splitting tree algorithm for molecular descriptors (SITAd). Our approach extends efficient methods for binary-vector databases, and uses ideas from succinct data structures. Our experiments, on a large database of over 40 million compounds, show SITAd significantly outperforms alternative approaches in practice.Comment: To be appeared in the Proceedings of SISAP'1

Enhanced Parallel Hash Function Algorithm Based on 3C Construction (EPHFA-3C)

The hash function is a function that can convert data from variable size to fixed-size data that can be used in security of communication like, authentication, digital signature and integration. In this paper, a parallel, secure and fast hash function algorithm that is based on 3C construction is proposed. It is an enhancement for the MD construction. This enhancement makes the construction more resistant to the extension and multi-blocks attacks. The parallel structure of the algorithm improves the speed of hashing and reduces the number of operations. The simulation analysis such as hashes distribution, confusion and diffusion properties, and collision resistance are executed. Based on the results, our proposed hash algorithm is efficient, simple, and has strong security compared with some recent hash algorithms

N-acetylcysteine compared to metformin, improves the expression profile of growth differentiation factor-9 and receptor tyrosine kinase c-kit in the oocytes of patients with polycystic ovarian syndrome

Background: Paracrine disruption of growth factors in women with polycystic ovarian syndrome (PCOS) results in production of low quality oocyte, especially following ovulation induction. The aim of this study was to investigate the effects of metformin (MET), N-acetylcysteine (NAC) and their combination on the hormonal levels and expression profile of GDF-9, BMP-15 and c-kit, as hallmarks of oocyte quality, in PCOS patients. Materials and Methods: This prospective randomized, double-blind, placebo controlled trial aims to study the effects of MET, NAC and their combination (MET+NAC) on expression of GDF-9, BMP-15 and c-kit mRNA in oocytes [10 at the germinal vesicle (GV) stage, 10 at the MI stage, and 10 at the MII stage from per group] derived following ovulation induction in PCOS. Treatment was carried out for six weeks, starting on the third day of previous cycle until oocyte aspiration. The expression of GDF9, BMP15 and c-kit were determined by quantitative real time polymerase chain reaction (RT-qPCR) and western blot analysis. Data were analyzed with one-way ANOVA. Results: The follicular fluid (FF) level of c-kit protein significantly decreased in the NAC group compared to the other groups. Significant correlations were observed between the FF soluble c-kit protein with FF volume, androstenedione and estradiol. The GDF-9 expression in unfertilized mature oocytes were significantly higher in the NAC group compared to the other groups (P<0.001). Similar difference was not observed between the MET, NAC+MET and control groups. The c-kit expression in unfertilized mature oocytes were significantly lower in the NAC group compared to the other groups (P<0.001). Similar difference was not observed between the MET, NAC+MET and control groups (Registration number: IRCT201204159476N1). Conclusion: We concluded that NAC can improve the quality of oocytes in PCOS. © 2017, Royan Institute (ACECR). All rights reserved