MAGE-A3/4 and NY-ESO-1 antigens expression in metastatic esophageal squamous cell carcinoma

In the present study we analyzed immunohistochemical expression of MAGE-A 3/4 and NY-ESO-1 in 55 samples of esophageal squamous cell carcinomas (ESCC) and their respective lymph node metastases. To our knowledge this is the first study to assess and compare the expression of these antigens in ESCC lymph node metastases

Hamiltonian analysis of Poincar\'e gauge theory scalar modes

The Hamiltonian constraint formalism is used to obtain the first explicit complete analysis of non-trivial viable dynamic modes for the Poincar\'e gauge theory of gravity. Two modes with propagating spin-zero torsion are analyzed. The explicit form of the Hamiltonian is presented. All constraints are obtained and classified. The Lagrange multipliers are derived. It is shown that a massive spin-$0^-$ mode has normal dynamical propagation but the associated massless $0^-$ is pure gauge. The spin-$0^+$ mode investigated here is also viable in general. Both modes exhibit a simple type of ``constraint bifurcation'' for certain special field/parameter values.Comment: 28 pages, LaTex, submitted to International Journal of Modern Physics

Almost-homogeneity of the universe in higher-order gravity

In the $R+\alpha R^2$ gravity theory, we show that if freely propagating massless particles have an almost isotropic distribution, then the spacetime is almost Friedmann-Robertson-Walker (FRW). This extends the result proved recently in general relativity ($\alpha=0$), which is applicable to the microwave background after photon decoupling. The higher-order result is in principle applicable to a massless species that decouples in the early universe, such as a relic graviton background. Any future observations that show small anisotropies in such a background would imply that the geometry of the early universe were almost FRW.Comment: 14 pages LaTeX, no figures; to appear in General Relativity and Gravitatio

Safety of Simultaneous Resections of Colorectal Cancer and Liver Metastases

Liver resection is the only potentially curative method for patients with colorectal cancer metastases and 5-year survival rates are 20% – 40%. Simultaneous resection of colorectal cancer and synchronous liver metastases has been recommended if minor hepatectomy is indicated. The purpose of this paper is to analyze the treatment of hepatic colorectal secondaries and to assess the safety of simultaneous and delayed liver resections and relations of morbidity to the extensiveness of hepatectomy and perioperative factors. Analyzed were 21 patients with liver metastases from colorectal cancer operated between 1997 and 1999 in the Clinical Hospital »Sestre milosrdnice«. Operating time for simultaneous colorectal and liver resections was not significantly longer compared to liver resections alone. No significant difference in complication rate was found after simultaneous procedures and liver resection alone (38% vs. 31%). Complication rate after major liver resections was not significantly greater than after minor resections (38% vs. 31%). No statistically significant differences were found in operation time and blood replacement between patients who developed postoperative complications and those who did not. In conclusion, simultaneous resections of primary colorectal cancer and liver metastases may be considered safe. Morbidity rates are not significantly different from those after liver resections alone, nor depend significantly upon the extensiveness of liver resection, providing that the operation time and blood loss are within the range observed in this study

Cascade Birth of Universes in Multidimensional Spaces

The formation mechanism of universes with distinctly different properties is considered within the framework of pure gravity in a space of D > 4 dimensions. The emergence of the Planck scale and its relationship to the inflaton mass are discussed.Comment: 10 p., minor correction

Quantum Cosmology and Open Universes

Quantum creation of Universes with compact spacelike sections that have curvature $k$ either closed, flat or open, i.e. $k=\pm1,0$ are studied. In the flat and open cases, the superpotential of the Wheeler De Witt equation is significantly modified, and as a result the qualitative behaviour of a typical wavefunction differs from the traditional closed case. Using regularity arguments, it is shown that the only consistent state for the wavefunction is the Tunneling one. By computing the quantum probabilities for the curvature of the sections, it is shown that quantum cosmology actually favours that the Universe be open, $k=-1$. In all cases sufficient inflation $\sim 60$ e-foldings is predicted: this is an improvement over classical measures that generally are ambiguous as to whether inflation is certain to occur.Comment: 11 pages, Revtex, 7 figures. Accepted for publication in PRD. New material and important corrections added in response to referee's repor

Space for Both No-Boundary and Tunneling Quantum States of the Universe

At the minisuperspace level of homogeneous models, the bare probability for a classical universe has a huge peak at small universes for the Hartle-Hawking `no-boundary' wavefunction, in contrast to the suppression at small universes for the `tunneling' wavefunction. If the probability distribution is cut off at the Planck density (say), this suggests that the former quantum state is inconsistent with our observations. For inhomogeneous models in which stochastic inflation can occur, it is known that the idea of including a volume factor in the observational probability distribution can lead to arbitrarily large universes' being likely. Here this idea is shown to be sufficient to save the Hartle-Hawking proposal even at the minisuperspace level (for suitable inflaton potentials), by giving it enough space to be consistent with observations.Comment: LaTeX, 20 pages, no figures, blank lines removed, page break inserte

Accelerating Cosmologies and Inflation from M/Superstring Theories

We review the recent developments in obtaining accelerating cosmologies and/or inflation from higher-dimensional gravitational theories, in particular superstring theories in ten dimensions and M-theory in eleven dimensions. We first discuss why it is difficult to obtain inflationary behavior in the effective low-energy theories of superstring/M-theory, i. e. supergravity theories. We then summarize interesting solutions including S-branes that give rise to accelerating cosmologies and inflationary solutions in M-theory with higher order corrections. Other approaches to inflation in the string context are also briefly discussed.Comment: 38 pages, Invited review to be published in IJMPA, v2: slightly expanded and refs. added, v3, v4: typos corrected, published versio