Analytical-numerical methods of calculations of energy and three-dimensional particle distributions in electromagnetic cascades

Analytical and numerical methods of calculation of the energy and three dimensional EPS characteristics are reported. The angular and lateral functions of electrons in EPS have been obtained by the Landau and small angle approximations A and B and compared with earlier data. A numerical method of solution of cascade equations for the EPS distribution function moments has been constructed. Considering the equilibrium rms angle as an example, errors appearing when approximating the elementary process cross sections by their asymptotic expressions are analyzed

Electromagnetic showers in a strong magnetic field

We present the results concerning the main shower characteristics in a strong magnetic field obtained through shower simulation. The processes of magnetic bremsstrahlung and pair production were taken into account for values of the parameter $\chi \gg 1$. We compare our simulation results with a recently developed cascade theory in a strong magnetic field.Comment: 11 pages, 9 eps figures, LaTex2e, Iopart.cls, Iopart12.clo, Iopams.st

Investigating knowledge management factors affecting Chinese ICT firms performance: An integrated KM framework

This is an Author's Accepted Manuscript of an article published in the Journal of Information Systems Management, 28(1), 19 - 29, 2011, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/10580530.2011.536107.This article sets out to investigate the critical factors of Knowledge Management (KM) which are considered to have an impact on the performance of Chinese information and communication technology (ICT) firms. This study confirms that the cultural environment of an enterprise is central to its success in the context of China. It shows that a collaborated, trusted, and learning environment within ICT firms will have a positive impact on their KM performance

Space-VLBI observations of OH maser OH34.26+0.15: low interstellar scattering

We report on the first space-VLBI observations of the OH34.26+0.15 maser in two main line OH transitions at 1665 and 1667 MHz. The observations involved the space radiotelescope on board the Japanese satellite HALCA and an array of ground radio telescopes. The map of the maser region and images of individual maser spots were produced with an angular resolution of 1 milliarcsec which is several times higher than the angular resolution available on the ground. The maser spots were only partly resolved and a lower limit to the brightness temperature 6x10^{12} K was obtained. The maser seems to be located in the direction of low interstellar scattering, an order of magnitude lower than the scattering of a nearby extragalactic source and pulsar.Comment: 8 pages, 2 tables, 9 figures, accepted for publication in MNRA

Ultra-High Energy Gamma Rays in Geomagnetic Field and Atmosphere

The nature and origin of ultra-high energy (UHE: reffering to > 10^19 eV) cosmic rays are great mysteries in modern astrophysics. The current theories for their explanation include the so-called "top-down" decay scenarios whose main signature is a large ratio of UHE gamma rays to protons. Important step in determining the primary composition at ultra-high energies is the study of air shower development. UHE gamma ray induced showers are affected by the Landau-Pomeranchuk-Migdal (LPM) effect and the geomagnetic cascading process. In this work extensive simulations have been carried out to study the characteristics of air showers from UHE gamma rays. At energies above several times 10^19 eV the shower is affected by geomagnetic cascading rather than by the LPM effect. The properties of the longitudinal development such as average depth of the shower maximum or its fluctuations depend strongly on both primary energy and incident direction. This feature may provide a possible evidence of the UHE gamma ray presence by fluorescence detectors.Comment: 27 pages, 12 figures, submitted to Phys.Rev.

Anion-Sensitive Regions of L-Type CaV1.2 Calcium Channels Expressed in HEK293 Cells

L-type calcium currents (ICa) are influenced by changes in extracellular chloride, but sites of anion effects have not been identified. Our experiments showed that CaV1.2 currents expressed in HEK293 cells are strongly inhibited by replacing extracellular chloride with gluconate or perchlorate. Variance-mean analysis of ICa and cell-attached patch single channel recordings indicate that gluconate-induced inhibition is due to intracellular anion effects on Ca2+ channel open probability, not conductance. Inhibition of CaV1.2 currents produced by replacing chloride with gluconate was reduced from ∼75%–80% to ∼50% by omitting β subunits but unaffected by omitting α2δ subunits. Similarly, gluconate inhibition was reduced to ∼50% by deleting an α1 subunit N-terminal region of 15 residues critical for β subunit interactions regulating open probability. Omitting β subunits with this mutant α1 subunit did not further diminish inhibition. Gluconate inhibition was unchanged with expression of different β subunits. Truncating the C terminus at AA1665 reduced gluconate inhibition from ∼75%–80% to ∼50% whereas truncating it at AA1700 had no effect. Neutralizing arginines at AA1696 and 1697 by replacement with glutamines reduced gluconate inhibition to ∼60% indicating these residues are particularly important for anion effects. Expressing CaV1.2 channels that lacked both N and C termini reduced gluconate inhibition to ∼25% consistent with additive interactions between the two tail regions. Our results suggest that modest changes in intracellular anion concentration can produce significant effects on CaV1.2 currents mediated by changes in channel open probability involving β subunit interactions with the N terminus and a short C terminal region

СПОСОБ РАЗДЕЛЬНОГО ОПРЕДЕЛЕНИЯ СОПРОТИВЛЕНИЙ ОБРАЗЦА ВЫСОКООМНОГО ПОЛУПРОВОДНИКА И КОНТАКТОВ К ОБРАЗЦУ

The method of separate determination of two−pole sample volume resistance and contact resistance is suggested. The method described is applicable to high−ohmic semiconductor samples: semiinsulating gallium arsenide, detector cadmium−zinc tel- luride (CZT), etc. The method is based on near−contact region illumination by monochromatic radiation of variable intensity from light emitting diodes with quantum energy exceeding band gap width of investigated material. It is necessary to obtain sample photo−current dependence upon light emitting diode current and to find the straight−line part of this dependence. The extrapola- tion of this linear part to ordinate axis gives cut−off current value. As bias voltage is known, it is easy to calculate sample volume resistance value. Afterwards, using dark current value, it is pos- sible to determine total contact resistance. The method was approbated on n−type semiinsulating GaAs sample. Contact resistance value was shown to be approximately equal to sample volume resistance. It means that influence of contacts must be taken into account when electrophysical data is analyzed.Предложен метод раздельного определения сопротивлений образца−двухполюсника и контактов к нему, который применим к образцам высокоомных полупроводниковых материалов: полуизолирующего арсенида галлия, детекторного теллурида кадмия−цинка (КЦТ) и др. Метод основан на засветке приконтакных областей образца моно- хроматическим излучением регулируемой интенсивности от светодиодов с энергией кванта, превышающей ширину запрещенной зоны исследуемого материала. Экстраполяция прямолинейного участка зависимости фототока через образец от тока через светодиоды к оси ординат позволяет найти ток отсечки, после чего по из- вестным значениям тока отсечки и напряжения смещения вычисляют значение сопротивления объема об- разца. Далее, зная темновое значение тока через образец, можно вычислить суммарное сопротивление контактов образца−двухполюсника. Метод опробован на образце полуизолирующего арсенида галлия n−типа электропроводности. Линейность контактов проверена по вольт−амперным характеристикам. Показано, что сопротивление контактов близко к сопротивлению объема образца, что подтверждает необходимость учета влияния контактов при анализе данных электрофизических измерений

Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells

<p>Abstract</p> <p>Background</p> <p>Effective transvascular delivery of nanoparticle-based chemotherapeutics across the blood-brain tumor barrier of malignant gliomas remains a challenge. This is due to our limited understanding of nanoparticle properties in relation to the physiologic size of pores within the blood-brain tumor barrier. Polyamidoamine dendrimers are particularly small multigenerational nanoparticles with uniform sizes within each generation. Dendrimer sizes increase by only 1 to 2 nm with each successive generation. Using functionalized polyamidoamine dendrimer generations 1 through 8, we investigated how nanoparticle size influences particle accumulation within malignant glioma cells.</p> <p>Methods</p> <p>Magnetic resonance and fluorescence imaging probes were conjugated to the dendrimer terminal amines. Functionalized dendrimers were administered intravenously to rodents with orthotopically grown malignant gliomas. Transvascular transport and accumulation of the nanoparticles in brain tumor tissue was measured <it>in vivo </it>with dynamic contrast-enhanced magnetic resonance imaging. Localization of the nanoparticles within glioma cells was confirmed <it>ex vivo </it>with fluorescence imaging.</p> <p>Results</p> <p>We found that the intravenously administered functionalized dendrimers less than approximately 11.7 to 11.9 nm in diameter were able to traverse pores of the blood-brain tumor barrier of RG-2 malignant gliomas, while larger ones could not. Of the permeable functionalized dendrimer generations, those that possessed long blood half-lives could accumulate within glioma cells.</p> <p>Conclusion</p> <p>The therapeutically relevant upper limit of blood-brain tumor barrier pore size is approximately 11.7 to 11.9 nm. Therefore, effective transvascular drug delivery into malignant glioma cells can be accomplished by using nanoparticles that are smaller than 11.7 to 11.9 nm in diameter and possess long blood half-lives.</p