Cyberinfrastructure for Classical Philology

No humanists have moved more aggressively in the digital world than students of the Greco-Roman world but the first generation of digital classics has seen relatively superficial methods to address the problems of print culture. We are now beginning to see new intellectual practices for which new terms, eWissenschaft and eClassics, and a new cyberinfrastructure are emerging

4-Dimensional BF Theory as a Topological Quantum Field Theory

Starting from a Lie group G whose Lie algebra is equipped with an invariant nondegenerate symmetric bilinear form, we show that 4-dimensional BF theory with cosmological term gives rise to a TQFT satisfying a generalization of Atiyah's axioms to manifolds equipped with principal G-bundle. The case G = GL(4,R) is especially interesting because every 4-manifold is then naturally equipped with a principal G-bundle, namely its frame bundle. In this case, the partition function of a compact oriented 4-manifold is the exponential of its signature, and the resulting TQFT is isomorphic to that constructed by Crane and Yetter using a state sum model, or by Broda using a surgery presentation of 4-manifolds.Comment: 15 pages in LaTe

Policy measures and cyber insurance: a framework

The role of the insurance industry in driving improvements in cyber security has been identified as mutually beneficial for both insurers and policy-makers. To date, there has been no consideration of the roles governments and the insurance industry should pursue in support of this public–private partnership. This paper rectifies this omission and presents a framework to help underpin such a partnership, giving particular consideration to possible government interventions that might affect the cyber insurance market. We have undertaken a qualitative analysis of reports published by policy-making institutions and organisations working in the cyber insurance domain; we have also conducted interviews with cyber insurance professionals. Together, these constitute a stakeholder analysis upon which we build our framework. In addition, we present a research roadmap to demonstrate how the ideas described might be taken forward

Electron Transfer Reactivity of Type Zero Pseudomonas aeruginosa Azurin

Type zero copper is a hard-ligand analogue of the classical type 1 or blue site in copper proteins that function as electron transfer (ET) agents in photosynthesis and other biological processes. The EPR spectroscopic features of type zero Cu^(II) are very similar to those of blue copper, although lacking the deep blue color, due to the absence of thiolate ligation. We have measured the rates of intramolecular ET from the pulse radiolytically generated C3−C26 disulfide radical anion to the Cu^(II) in both type zero C112D/M121L and type 2 C112D Pseudomonas aeruginosa azurins in pH 7.0 aqueous solutions between 8 and 45 °C. We also have obtained rate/temperature (10−30 °C) profiles for ET reactions between these mutants and the wild-type azurin. Analysis of the rates and activation parameters for both intramolecular and intermolecular ET reactions indicates that the type zero copper reorganization energy falls in a range (0.9−1.1 eV) slightly above that for type 1 (0.7−0.8 eV), but substantially smaller than that for type 2 (>2 eV), consistent with XAS and EXAFS data that reveal minimal type zero site reorientation during redox cycling

Rabx-5 Regulates RAB-5 Early Endosomal Compartments and Synaptic Vesicles in C. elegans

Early endosomal membrane compartments are required for the formation and recycling of synaptic vesicles, but how these compartments are regulated is incompletely understood. We performed a forward genetic screen in C. elegans for mutations that affect RAB-5 labeled early endosomal compartments in GABAergic motoneurons. Here we report the isolation and characterization of one mutation, rabx-5. The rabx-5 mutation leads to decreased intensity of YFP::RAB-5 in the cell soma but increased intensity in the synaptic and intersynaptic regions of the axon. This effect is due to the bias of the cycling state of RAB-5, and results from a change in the organization of the early endosomal compartment as well as the membrane binding state of RAB-5. Synaptic vesicle accumulation is altered in rabx-5 mutants, and synaptic transmission from cholinergic neurons is decreased. Early endosomal membrane compartments show disorganization with ageing and rabx-5 mutant animals age faster. These results suggest that rabx-5 regulation of RAB-5 compartments is important for maintaining proper synaptic function throughout the lifetime

Old and New Fields on Super Riemann Surfaces

The ``new fields" or ``superconformal functions" on $N=1$ super Riemann surfaces introduced recently by Rogers and Langer are shown to coincide with the Abelian differentials (plus constants), viewed as a subset of the functions on the associated $N=2$ super Riemann surface. We confirm that, as originally defined, they do not form a super vector space.Comment: 9 pages, LaTex. Published version: minor changes for clarity, two new reference

Must naive realists be relationalists?

Relationalism maintains that perceptual experience involves, as part of its nature, a distinctive kind of conscious perceptual relation between a subject of experience and an object of experience. Together with the claim that perceptual experience is presentational, relationalism is widely believed to be a core aspect of the naive realist outlook on perception. This is a mistake. I argue that naive realism about perception can be upheld without a commitment to relationalism

The Geography of Scientific Productivity: Scaling in U.S. Computer Science

Here we extract the geographical addresses of authors in the Citeseer database of computer science papers. We show that the productivity of research centres in the United States follows a power-law regime, apart from the most productive centres for which we do not have enough data to reach definite conclusions. To investigate the spatial distribution of computer science research centres in the United States, we compute the two-point correlation function of the spatial point process and show that the observed power-laws do not disappear even when we change the physical representation from geographical space to cartogram space. Our work suggests that the effect of physical location poses a challenge to ongoing efforts to develop realistic models of scientific productivity. We propose that the introduction of a fine scale geography may lead to more sophisticated indicators of scientific output.Comment: 6 pages, 3 figures; minor change