Avaliação ecônomica de criadouro de capivaras em sistema semi-intesivo para a região costeira sul do Rio Grande do Sul.

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Authors' Reply To the Letters to the Editor by Puklin et al and by Iyengar and Ligibel

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Institutionalising smart city research and innovation: from fuzzy definitions to real-life experiments

By exploring and defining characteristics of a smart city research and innovation centre, we contribute to the discussion on smart city development capacity. To do so, using a qualitative method, we review definitions of the concept and map international groups and institutes affiliated with this domain. Our main result is an overview of global research centres dealing with smart cities. One of the key implications of this paper is that instead of a strict definition, the important aspect appears in the framing provided by the complex real-life challenges that require and enable cross-disciplinary research, even though the concept keeps evolving

Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by post-operative trastuzumab for patients with HER2-positive breast cancer

Neoadjuvant chemotherapy plus trastuzumab (NCT) increases the rate of pathological complete response (pCR) and event-free survival (EFS) compared to neoadjuvant chemotherapy (NC) alone in women with HER2 positive breast cancer (BC). pCR in this setting is associated with improved EFS. Whether NCT preferentially improves EFS in comparison to NC followed by adjuvant trastuzumab initiated postoperatively (NCAT) has not been addressed. Using clinical data from women with HER2 positive BC treated at 7 European institutions between 2007 and 2010 we sought to investigate the impact on breast cancer outcomes of concomitant (NCT) versus sequential (NCAT) treatment in HER2 positive early BC. The unadjusted hazard ratio (HR) for event free survival with NCT compared with NCAT was 0.63 (95% CI 0.37–1.08; p = 0.091). Multivariable analysis revealed that treatment group, tumour size and ER status were significantly associated with EFS from diagnosis. In the whole group NCT was associated with a reduced risk of an event relative to NCAT, an effect that was confined to ER negative (HR: 0.25; 95% CI, 0.10–0.62; p = 0.003) as opposed to ER positive tumours (HR: 1.07; 95% CI, 0.46–2.52; p = 0.869). HER2 positive/ER negative BC treated with NC gain greatest survival benefit when trastuzumab is administered in both the neoadjuvant and adjuvant period rather than in the adjuvant period alone. These data support the early introduction of targeted combination therapy in HER2 positive/ER negative BC

Evaluating Software-based Hardening Techniques for General-Purpose Registers on a GPGPU

Graphics Processing Units (GPUs) are considered a promising solution for high-performance safety-critical applications, such as self-driving cars. In this application domain, the use of fault tolerance techniques is mandatory to detect or correct faults, since they must work properly even in the presence of faults. GPUs are designed with aggressive technology scaling, which makes them susceptible to faults caused by radiation interference, such as the Single Event Upsets (SEUs), which can lead the system to fail, and that is unacceptable in safety-critical applications. In this paper, we evaluate different software-based hardening techniques developed to detect SEUs in GPUs general-purpose registers and propose optimizations to improve performance and memory utilization. The techniques are implemented in three case-study applications and evaluated in a general-purpose soft-core GPU based on the NVIDIA G80 architecture. A fault injection campaign is performed at register transfer level to assess the fault detection potential of the implemented techniques. Results show that the proposed improvements can be tailored for different scenarios, helping engineers in navigating the design space of hardened GPGPU applications

Analyzing the Sensitivity of GPU Pipeline Registers to Single Events Upsets

Graphics processing units are available solutions for high-performance safety-critical applications, such as self-driving cars. In this application domain, functional-safety and reliability are major concerns. Thus, the adoption of fault tolerance techniques is mandatory to detect or correct faults, since these devices must work properly, even when faults are present. GPUs are designed and implemented with cutting-edge technologies, which makes them sensitive to faults caused by radiation interference, such as single event upsets. These effects can lead the system to a failure, which is unacceptable in safety-critical applications. Therefore, effective detection and mitigation strategies must be adopted to harden the GPU operation. In this paper, we analyze transient effects in the pipeline registers of a GPU architecture. We run four applications at three GPU configurations, considering the source of the fault, its effect on the GPU, and the use of software-based hardening techniques. The evaluation was performed using a general-purpose soft-core GPU based on the NVIDIA G80 architecture. Results can guide designers in building more resilient GPU architectures

Avaliação dos impactos ambientais e econômicos da cultivar de arroz irrigado BRS Querência.

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Empreendedorismo high-tech no Brasil:: Condicionantes econômicos, políticos e culturais

O artigo aborda o fenômeno do empreendedorismo tecnológico, em crescimento no Brasil, estimulado sobretudo pelo avanço das tecnologias de informação e comunicação e por ações governamentais como a Política de Desenvolvimento Produtivo, de maio de 2008, que propõe aumento de 10% no número de micro e pequenas exportadoras, até 2010. O estudo baseia-se em uma abordagem multidimensional que destaca a importância de aspectos econômicos, institucionais, culturais e cognitivos e que supõe uma articulação entre fatores objetivos e subjetivos, entre níveis micro e macro. Os dados empíricos foram coletados através de entrevistas realizadas com empreendedores cujas empresas encontram-se em incubadoras tecnológicas, localizadas em três campi de universidades, no estado do Rio Grande do Sul. As evidências encontradas reforçam a hipótese de que estaria ocorrendo o que se poderia chamar de "mudança cultural", no sentido de que profissionais com alta qualificação, demandados pelo mercado de trabalho, apresentam comportamentos, valores e objetivos, distintos dos esperados - obter um emprego bem remunerado em uma grande empresa, pública ou privada; ênfase nos valores econômicos; individualismo; exercício de poder

Platinum-based neoadjuvant chemotherapy in triple-negative breast cancer: a systematic review and meta-analysis

Background: The role of platinum-based neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) patients is highly controversial and it is not endorsed by current guidelines. Our meta-analysis aimed to better elucidate its activity, efficacy and safety. Material and methods: A systematic search of Medline, Web of Science and conferences proceedings up to 30 October 2017 was carried out to identify randomized controlled trials (RCTs) investigating platinum-based versus platinum-free neoadjuvant chemotherapy in TNBC patients. Using the fixed and random effects models, pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CI) were calculated for pathological complete response (pCR, defined as ypT0/is pN0), event-free survival (EFS), overall survival (OS) and grade 3 and 4 adverse events (AEs: neutropenia, anemia, thrombocytopenia and neuropathy). Results: Nine RCTs (N \ubc 2109) were included. Overall, platinum-based neoadjuvant chemotherapy significantly increased pCR rate from 37.0% to 52.1% (OR 1.96, 95% CI 1.46\u20132.62, P < 0.001). Platinum-based neoadjuvant chemotherapy remained significantly associated with increased pCR rate also after restricting the analysis to the three RCTs (N \ubc 611) that used the same standard regimen in both groups of weekly paclitaxel (with or without carboplatin) followed by anthracycline and cyclophosphamide (OR 2.53, 95% CI 1.37\u20134.66, P \ubc 0.003). Conversely, among the 96 BRCA-mutated patients included in two RCTs, the addition of carboplatin was not associated with significantly increased pCR rate (OR 1.17, 95% CI 0.51\u20132.67, P \ubc 0.711). Two RCTs (N \ubc 748) reported survival outcomes: no significant difference in EFS (HR 0.72, 95% CI 0.49\u20131.06, P \ubc 0.094) and OS (HR 0.86, 95% CI 0.46\u20131.63, P \ubc 0.651) was observed. A significant higher risk of grade 3 and 4 hematological AEs, with no increased risk of grade 3 and 4 neuropathy was observed with platinum-based neoadjuvant chemotherapy. Conclusion: In TNBC patients, platinum-based neoadjuvant chemotherapy is associated with significantly increased pCR rates at the cost of worse hematological toxicities. Platinum-based neoadjuvant chemotherapy may be considered an option in TNBC patients