10 research outputs found
Erratum - Comparison of recorded and calculated photoacoustic spectra of dye solutions
No abstract availabl
Promotion through external magnetic field of osteogenic differentiation potential in adiposeâderived mesenchymal stem cells: Design of polyurethane/poly(lactic) acid sponges doped with iron oxide nanoparticles
International audienceRecently, iron oxide nanoparticles (IONPs) have gathered special attention in regenerative medicine. Owing to their magnetic and bioactive properties, IONPs are utilized in the fabrication of novel biomaterials. Yet, there was no report regarding thermoplastic polyurethane (TPU) and poly(lactic acid) (PLA) polymer doped with IONPs on osteogenic differentiation of mesenchymal stem cells. Thus the objectives of presented study was to: (a) fabricate magnetic TPUâ+âPLA sponges doped with iron (III) oxide Fe2O3 nanoparticles; (b) investigate the effects of biomaterial and its exposition to static magnetic field (MF) on osteogenic differentiation, proliferation, and apoptosis in adiposeâderived mesenchymal stem cells (ASCs). TPUâ+âPLA sponges were prepared using solvent casting technique while incorporation of the Fe2O3 nanoparticles was performed with solution cast method. RTâPCR was applied to evaluate expression of osteogenicârelated genes and integrin's in cells cultured on fabricated materials with or without the stimulation of static MF. MF stimulation enhanced the expression of osteopontin and collagen type I while decreased expression of bone morphogenetic protein 2 in tested magnetic materialsâTPUâ+âPLA/1% Fe2O3 and TPUâ+âPLA/5% Fe2O3. Therefore, TPUâ+âPLA sponges doped with IONPs and exposure to MF resulted in improved osteogenic differentiation of ASC
Promotion through external magnetic field of osteogenic differentiation potential in adiposeâderived mesenchymal stem cells: Design of polyurethane/poly(lactic) acid sponges doped with iron oxide nanoparticles
International audienc