Screening mutation in RYR2 gene in a Kazakhstani idiopathic ventricular tachycardia study cohort: two novel mutations

The human ryanodine receptor 2 (RYR2) is one of the key players tightly regulating calcium efflux from the sarcoplasmic reticulum to the cytosol and found frequently mutated (<60%) in context of catecholaminergic polymorphic ventricular tachycardia (CPVT1) [1]

РАЗВИТИЕ МУСУЛЬМАНСКОГО ОБРАЗОВАНИЯ И ПРОФИЛАКТИКА ЭКСТРЕМИЗМА В БАШКОРТОСТАНЕ: НОВЫЕ АКЦЕНТЫ И ИННОВАЦИОННЫЕ ПРОЕКТЫ

Abstract. The article describes the current socio-cultural trends in the development of modern society. It also analyzes threats to social development and its possible risks. The authors examine the results of the activities of the M. Akmullah Bashkir State Pedagogical University regarding the development of Islamic education and prevention of extremism. The data of sociological research is presented. Аннотация. В статье рассмотрены актуальные социокультурные тенденции развития современного общества. Отдельно анализируются факторы угроз общественному развитию и вероятные риски. Представлены результаты деятельности Башкирского государственного педагогического университета им. М. Акмуллы по развитию системы исламского образования и профилактике экстремизма. Приводятся данные социологического исследования.

Rate Setting for Labour Costs Related to Pharmacovigilance System Inspections

The inspection of pharmacovigilance systems is regulated by the Good Pharmacovigilance Practices (GVP) and local laws and regulations. Inspections may be carried out by audit teams of competent authorities as part of regulatory activities or business agreements. So far, there have been no studies dealing with rate setting for competent authorities labour costs in connection with onsite or documentary inspections of pharmacovigilance systems.The aim of the study was to develop scientifically valid rate setting criteria for labour costs related to onsite or documentary inspections of pharmacovigilance systems.Materials and methods: the assessment of labour costs was carried out by surveying experts of two Eurasian Economic Union (EAEU) countries who have experience in preparing and conducting evaluation and inspection of pharmacovigilance systems. The calculation of the experts’ time costs was performed automatically using the CrocoTime software. The expected workload for experts in 2022 was estimated based on the reports over the last 5 years (2016–2020) containing information on the number of foreign marketing authorisations, and the number of medicines under development according to national registers of medicinal products of the EAEU member states.Results: the study calculated the average expert labour costs and estimated workload for the EAEU competent authorities in 2022. It was demonstrated that the average labour costs are comparable in EAEU member states, however, estimated amount of labour may change (both increase or decrease).Conclusions: further study of rate setting for labour costs related to pharmacovigilance documentary inspections and study of competent authorities staffing could be performed by a dedicated division, e.g. of the Eurasian Academy of Good Practices. A constructive discussion of approaches to the improvement of control over pharmacovigilance systems will increase availability of efficacious and safe medicines of assured quality for the population and help pharmaceutical companies and regulatory authorities manage financial and reputational risks

ASSESSMENT OF THE RESOURCE POTENTIAL OF THE BITTER - SALTY SULFIDE LAKES OF THE NORTH KAZAKHSTAN REGION FOR THE DEVELOPMENT OF ECOLOGICAL AND BALNEOLOGICAL TOURISM

To consider the resource potential of bitter-salty sulfide lakes for the development of ecological and balneological tourism in the territory of the North Kazakhstan region of the Republic of Kazakhstan. Field studies, a sociological survey were conducted, methods of statistical and mathematical processing were used. The cartographic method made it possible to visualize the studied material. Bitter-salty lakes contain sulfide mud, which is a unique natural resource. Mud can be used in combination with salt water to create the foundations of ecological and health tourism in the North Kazakhstan region. Research has revealed the most promising lakes of the region. The analysis of the obtained field research data and cartographic material made it possible to assess the resource potential of the lakes. These data were confirmed by the results of a sociological survey, which confirms the possibility of developing the tourism industry on the basis of unique local bitt ersalty lakes. The cartographic material created in the course of the study visually demonstrates the prospects and possible problems of the development of the health tourism industry in the territory of the studied region. The resources of bitter-salty sulfide lakes have sufficient potential for the development of tourism in the North Kazakhstan region. The bitter-salty lakes of the North Kazakhstan region selected on the basis of a comprehensive score have criteria confirming their resource potential. This assessment shows the possibility of developing health and ecological tourism in the region. The border position of the region makes it possible to develop not only internal, but also external tourism

Rabies in the Republic of Kazakhstan: spatial and temporal characteristics of disease spread over one decade (2013–2022)

Rabies is a fatal zoonotic disease that remains endemic in Kazakhstan despite the implementation of annual vaccination campaigns. Using data collected over a 10-year time period, the objective of this study was to provide updated information on the epidemiological situation of the disease in the country, and quantitative data on the species-specific spatial distribution of rabies and on the epidemiological features associated with that clustering. Five significant (p &lt; 0.05) clusters of disease were detected. Clusters in southern Kazakhstan were associated with companion animals, which are likely explained by the maintenance of a domestic cycle of the disease in the most densely populated region of the country. Livestock cases were most frequent in clusters in the eastern (where wildlife cases were also frequent) and western regions of Kazakhstan, with higher probability of occurrence in spring and summer, compared to the rest of the year. The results here are consistent with differential patterns for disease transmission in Kazakhstan and will contribute to the design and implementation of zoning approaches to support the progressive control of rabies in the country

The progressive control of foot-and-mouth disease (FMD) in the Republic of Kazakhstan: Successes and challenges

Foot-and-mouth disease (FMD) has historically caused far-reaching economic losses to many regions worldwide. FMD control has been problematic, and the disease is still prevalent in many West and Central Asia countries. Here, we review the progress made by Kazakhstan in achieving freedom from FMD and discuss some of the challenges associated with maintaining the FMD-free status, as evidenced by the occurrence of an outbreak in 2022. A combination of zoning, movement control, vaccination, and surveillance strategies led to eliminating the disease in the country. However, the circulation of the FMD virus in the region still imposes a risk for Kazakhstan, and coordinated strategies are ultimately needed to support disease elimination. The results presented here may help design effective pathways to progressively eliminate the disease in West and Central Asia while promoting the design and implementation of regional actions to support FMD control

Modified Ross operation (literature review)

One of the surgical methods for treating aortic valve pathology is the Ross operation, which was proposed by the British cardiac surgeon D. Ross in 1967. Numerous studies have shown excellent long-term outcomes of this operation. However, in some patients, pulmonary autograft dilatation may occur in the long term. To avoid this complication, technical modifications of this procedure have been proposed. A literature review on modified Ross operation as a prevention of pulmonary autograft dilatation is presented

A comprehensive collection of chicken cDNAs

AbstractBirds have played a central role in many biological disciplines, particularly ecology, evolution, and behavior. The chicken, as a model vertebrate, also represents an important experimental system for developmental biologists, immunologists, cell biologists, and geneticists. However, genomic resources for the chicken have lagged behind those for other model organisms, with only 1845 nonredundant full-length chicken cDNA sequences currently deposited in the EMBL databank. We describe a large-scale expressed-sequence-tag (EST) project aimed at gene discovery in chickens (http://www.chick.umist.ac.uk). In total, 339,314 ESTs have been sequenced from 64 cDNA libraries generated from 21 different embryonic and adult tissues. These were clustered and assembled into 85,486 contiguous sequences (contigs). We find that a minimum of 38% of the contigs have orthologs in other organisms and define an upper limit of 13,000 new chicken genes. The remaining contigs may include novel avian specific or rapidly evolving genes. Comparison of the contigs with known chicken genes and orthologs indicates that 30% include cDNAs that contain the start codon and 20% of the contigs represent full-length cDNA sequences. Using this dataset, we estimate that chickens have approximately 35,000 genes in total, suggesting that this number may be a characteristic feature of vertebrates

Assessment of awareness of workers of the forensic medical service of the republic of Tatarstan (bureau) about tuberculosis infection

Purpose of the study — to examine the awareness of bureau personnel about the main issues of tuberculosis infection, its prevention, ways of infection, diagnosis, and clinical manifestationsЦель исследования — изучить информированность персонала бюро об основных вопросах туберкулезной инфекции, ее профилактике, способах заражения, диагностике и клинических проявления

Transcatheter Aortic Valve Replacement in Aortic Stenosis: a Clinical Case

Background. Aortic valve stenosis is common with prevalence of about 0.5 %, peaking in people aged over 70 years mostly due to age-related valve calcification. The year 2002 was marked by the invention and use of the endovascular aortic replacement valve by an A. Cribier’s group of French surgeons. Russian endovascular surgery introduced transcatheter aortic valve replacement in 2009, having since built an extensive experience in this practice. Perioperative mortality in patients under 70 years with no serious comorbidity ranges from 1 to 3 %, however, reaching two-fold 4–8 % in elderly patients. The emergence of minimally invasive technologies offered cure to critical patients, who would merely not get over an open surgery.Materials and methods. This case study provides video recordings of transcatheter aortic valve replacement (Accurate Neo) in transfemoral approach performed for the first time in the Republic of Bashkortostan. Patient K., 70 yo, diagnosis: Atherosclerosis. Aortic valve stenosis. FC III. Complications: aortic valve calcification st. III, CHF II A, FC III, persistent atrial fibrillation, tachysystole. Comorbid: CHD. Exertional angina. FC III. CHF II A, FC III.Results and discussion. Improving the transcatheter valve type facilitates an optimal individual aortic valve selection. Pre-replacement valvuloplasty was performed in all patients. The valve replacement is followed by transoesophageal echocardiography to justify possible aortic valve post-dilatation upon marked paravalvular regurgitation. The implant positioning relative to the aortic valve fibrous crown and mitral valve flaps is precisely controlled with ultrasound.Conclusion. Interventional radiology currently provides high-quality, effective, minimally invasive medical aid even in aortic stenosis patients with multiple comorbidity. In the patient’s denial of open surgery, transcatheter aortic valve replacement represents a sole alternative treatment, also increasing the life expectancy and quality. A wider diversity of available transcatheter devices enables a better personalisation of the biological valve replacement procedure