The influence of feed additive “Sylimevit” on indicators of the immune system of piglets at weaning

In the development of adaptive reactions during weaning, biological mechanisms are involved with the complete mobilization of the functional reserve, an increase in the level of catecholamines, corticosteroids, and mediators, which is accompanied by a violation of the nitrogen balance in the body, enzymopathy, and endotoxemia—the work aimed to investigate humoral and non-specific immunity indicators in piglets after weaning. Experiments were conducted based on the Ltd “KOSHET” of the Mukachiv district of the Zakarpattia region. Two groups of piglets were formed – control and experimental in the number of 10 individuals in each group, selected according to the principle of analogs – age, breed, and body weight. Weaning piglets from sows at 28 days suppress the humoral link of natural resistance. A decrease in lysocin and bactericidal activity of blood serum was established at 40.56 ± 1.75 and 21.22 ± 1.05 %. The content of circulating immune complexes in the blood of piglets of the control group remained high after weaning. Along with a decrease in the activity of the humoral link of immunity in weaned piglets, suppression of the non-specific link of the immune system was established, manifested by a decrease in phagocytic activity and a decrease in the number of phagocytes. Feeding the feed supplement “Sylimevit” to the piglets of the research group helped to strengthen the immune status of the piglets' bodies. In piglets of the research group on the 35th day of life, when feeding the feed additive “Sylimevit”, an increase in the phagocytic activity of neutrophils by 4.26 % was established. Similar differences were obtained regarding the effect of the Butaselmevit-plus feed additive on the phagocytic number and the phagocytic index, in particular, in piglets of the experimental group on the 35th day of the experiment; they were 7.63 and 11.1 % higher than in control. These research results confirm the effectiveness of using milk thistle, methifen, selenium, and vitamins as part of the feed supplement “Sylimevit” for piglets before and after weaning to activate the protective systems of their body

Влияние препарата содержащего природный минерал бишофит на микрофлору полости рта

The oral cavity can be considered as an ecological system complex in which external factors (biological, individual, social) interact with internal ones (periodontium, bacterial community, local immune system, oral epithelium). If the favorable conditions arise, one or another disease of the oral mucosa may be developed and must be adequately treated. The arsenal of drugs is large and requires the doctor's knowledge, skills in using of the most optimal means and providing the appropriate recommendations to the patient. We studied the efficacy of the oral care product Antiqua Mare MAX, containing natural mineral Poltava’s Bischofite, on the representatives of the oral microflora. To achieve this goal, museum strains of E. coli ATCC 25922, S. aureus ATCC 25923, S. epidermidis ATCC 14990, E. faecalis ATCC 29212, M. lysodeicticus ATCC 4698 and C. albicans ATCC1023 were used. As a control, a well-known antimicrobial agent 0.02% aqueous solution of chlorhexidine bigluconate was used. The ability of the Antiqua Mare MAX drug to inhibit the growth of museum cultures of the yeast-like fungi, colon bacilli, enterococci, micrococci, epidermal and golden staphylococci in the liquid medium was shown to coincide completely in three repeated determinations during the study of the effect of Bischofite containing oral care product. The fungiostatic activity of the studied preparation Antiqua Mare MAX exceeded the effect of 0.02% solution of chlorhexidine bigluconate by 4 times (p<0,001), but the fungicidal effect did not differ.Порожнину рота можна розглядати як комплексну екологічну систему, в якій зовнішні фактори (біологічні, індивідуальні, соціальні) взаємодіють із внутрішніми (пародонт, бактеріальне співтовариство, локальна імунна система, епітелій порожнини рота). При виникненні сприятливих умов може розвинутись те чи інше захворювання яке необхідно лікувати. Ми вивчали ефективність впливу засобу по догляду за ротовою порожниною Antiqua Mare MAX, що вміщує природний мінерал Бішофіт Полтавський, на представників мікрофлори порожнини рота. Для вирішення поставленої мети використовували музейні штами E. Coli АТСС 25922, S. Aureus АТСС 25923, S. Epidermidis АТСС 14990, E. faecalis АТСС 29212, M. Lysodeiсticus АТСС 4698 та C. Albicans АТСС1023. У якості контролю використовували відомий антимікробний засіб - 0,02% водний розчин хлоргексидину біглюконат. Фунгіостатична активність дослідного препарату перевищувала дію 0,02% розчину хлоргексидину біглюконату у 4 рази (p<0,001) , але фунгіцидна дія не відрізнялась.Полость рта можно рассматривать как комплексную экологическую систему, в которой внешние факторы (биологические, индивидуальные, социальные) взаимодействуют с внутренними (пародонт, бактериальное сообщество, локальная иммунная система, эпителий полости рта). При возникновении благоприятных условий может развиться то или иное заболевание слизистой оболочки полости рта которое необходимо адекватно лечить. Мы изучали эффективность воздействия средства по уходу за полостью рта Antiqua Mare MAX, вмещающий природный минерал бишофит Полтавский, на представителей микрофлоры полости рта. Для решения поставленной цели использовали музейные штаммы E. coli АТСС 25922, S. aureus АТСС 25923, S. epidermidis АТСС 14990, E. faecalis АТСС 29212, M. lysodeiсticus АТСС 4698 и C. albicans АТСС1023. В качестве контроля применяли известное антимикробное средство - 0,02% водный раствор хлоргексидина биглюконат. Фунгиостатическая активность исследуемого препарата Antiqua Mare MAX превышала действие 0,02% раствора хлоргексидина биглюконата в 4 раза (p<0,001), однако, фунгицидное действие не отличалась