4,065 research outputs found
Piecewise smooth systems near a co-dimension 2 discontinuity manifold: can one say what should happen?
We consider a piecewise smooth system in the neighborhood of a co-dimension 2
discontinuity manifold . Within the class of Filippov solutions, if
is attractive, one should expect solution trajectories to slide on
. It is well known, however, that the classical Filippov
convexification methodology is ambiguous on . The situation is further
complicated by the possibility that, regardless of how sliding on is
taking place, during sliding motion a trajectory encounters so-called generic
first order exit points, where ceases to be attractive.
In this work, we attempt to understand what behavior one should expect of a
solution trajectory near when is attractive, what to expect
when ceases to be attractive (at least, at generic exit points), and
finally we also contrast and compare the behavior of some regularizations
proposed in the literature.
Through analysis and experiments we will confirm some known facts, and
provide some important insight: (i) when is attractive, a solution
trajectory indeed does remain near , viz. sliding on is an
appropriate idealization (of course, in general, one cannot predict which
sliding vector field should be selected); (ii) when loses attractivity
(at first order exit conditions), a typical solution trajectory leaves a
neighborhood of ; (iii) there is no obvious way to regularize the
system so that the regularized trajectory will remain near as long as
is attractive, and so that it will be leaving (a neighborhood of)
when looses attractivity.
We reach the above conclusions by considering exclusively the given piecewise
smooth system, without superimposing any assumption on what kind of dynamics
near (or sliding motion on ) should have been taking place.Comment: 19 figure
Catalytic Strand Separation by RECQ1 Is Required for RPA-Mediated Response to Replication Stress
SummaryThree (BLM, WRN, and RECQ4) of the five human RecQ helicases are linked to genetic disorders characterized by genomic instability, cancer, and accelerated aging [1]. RECQ1, the first human RecQ helicase discovered [2–4] and the most abundant [5], was recently implicated in breast cancer [6, 7]. RECQ1 is an ATP-dependent DNA-unwinding enzyme (helicase) [8, 9] with roles in replication [10–12] and DNA repair [13–16]. RECQ1 is highly expressed in various tumors and cancer cell lines (for review, see [17]), and its suppression reduces cancer cell proliferation [14], suggesting a target for anti-cancer drugs. RECQ1’s assembly state plays a critical role in modulating its helicase, branch migration (BM), or strand annealing [18, 19]. The crystal structure of truncated RECQ1 [20, 21] resembles that of E. coli RecQ [22] with two RecA-like domains, a RecQ-specific zinc-binding domain and a winged-helix domain, the latter implicated in DNA strand separation and oligomer formation. In addition, a conserved aromatic loop (AL) is important for DNA unwinding by bacterial RecQ [23, 24] and truncated RECQ1 helicases [21]. To better understand the roles of RECQ1, two AL mutants (W227A and F231A) in full-length RECQ1 were characterized biochemically and genetically. The RECQ1 mutants were defective in helicase or BM but retained DNA binding, oligomerization, ATPase, and strand annealing. RECQ1-depleted HeLa cells expressing either AL mutant displayed reduced replication tract length, elevated dormant origin firing, and increased double-strand breaks that could be suppressed by exogenously expressed replication protein A (RPA). Thus, RECQ1 governs RPA’s availability in order to maintain normal replication dynamics, suppress DNA damage, and preserve genome homeostasis
The Swiss Board Directors Network in 2009
We study the networks formed by the directors of the most important Swiss
boards and the boards themselves for the year 2009. The networks are obtained
by projection from the original bipartite graph. We highlight a number of
important statistical features of those networks such as degree distribution,
weight distribution, and several centrality measures as well as their
interrelationships. While similar statistics were already known for other board
systems, and are comparable here, we have extended the study with a careful
investigation of director and board centrality, a k-core analysis, and a
simulation of the speed of information propagation and its relationships with
the topological aspects of the network such as clustering and link weight and
betweenness. The overall picture that emerges is one in which the topological
structure of the Swiss board and director networks has evolved in such a way
that special actors and links between actors play a fundamental role in the
flow of information among distant parts of the network. This is shown in
particular by the centrality measures and by the simulation of a simple
epidemic process on the directors network.Comment: Submitted to The European Physical Journal
Study of radiation effects on bipolar transistors
Abstract In this paper it was shown that the irradiation with neutrons and carbon ions leads to gain degradation in bipolar transistors due to generation of defects. The density of these generated defects is independent of the type of irradiation (neutrons or carbon ions). Thus, it is possible to evaluate Δ(1/β), once the expected Frenkel pair density is known. The dependence of the damage constant on collector current is a power law function, with the exception of the lateral pnp transistors, that shows a higher sensitivity to radiation and a different behaviour. Neutrons give a smaller density of Frenkel pairs (CF) than the two sorts of carbon ions of high energy (CHE) and medium energy (CME). It was found that CME causes a higher concentration of CF. The calculated ratio R=CF/Φ, where CF is the Frenkel pair density and Φ fluence does not depend on Φ, for a given type of radiation. However, it depends on the incoming particle type. Its smallest calculated value was obtained for neutrons (R=6.1×10), which increases to 1.25×103 for CHE and to 1.1×104 for CME
Investigation of irradiated monolithic transistors for space applications
In this paper experimental results on radiation effects on a BICMOS high speed commercial technology, manufactured by STMicroelectronics, are reported. Bipolar transistors were irradiated by neutrons, ions, or by both of them. Fast neutrons, as well as other types of particles, produce defects, mainly by displacing silicon atoms from their lattice positions to interstitial locations, i.e. generating vacancy-interstitial pairs, the so-called Frenkel pairs (FP). Defects introduce trapping energy states which degrade the common emitter current gain β. The gain degradation has been investigated for collector current Ic between 1 μA and 1 mA. It was found a linear dependence of Δ(1/β)=1/βi−1/β (where βi and β are the gain after and before the irradiation) as a function of the concentration of FP. The bipolar transistors made on this technology have shown to be particularly radiation resistant. Both base and collector currents have been also systematically investigated
The evolution of interdisciplinarity in physics research
Science, being a social enterprise, is subject to fragmentation into groups
that focus on specialized areas or topics. Often new advances occur through
cross-fertilization of ideas between sub-fields that otherwise have little
overlap as they study dissimilar phenomena using different techniques. Thus to
explore the nature and dynamics of scientific progress one needs to consider
the large-scale organization and interactions between different subject areas.
Here, we study the relationships between the sub-fields of Physics using the
Physics and Astronomy Classification Scheme (PACS) codes employed for
self-categorization of articles published over the past 25 years (1985-2009).
We observe a clear trend towards increasing interactions between the different
sub-fields. The network of sub-fields also exhibits core-periphery
organization, the nucleus being dominated by Condensed Matter and General
Physics. However, over time Interdisciplinary Physics is steadily increasing
its share in the network core, reflecting a shift in the overall trend of
Physics research.Comment: Published version, 10 pages, 8 figures + Supplementary Informatio
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Turning points: the personal and professional circumstances that lead academics to become middle managers
In the current higher education climate, there is a growing perception that the pressures associated with being an academic middle manager outweigh the perceived rewards of the position. This article investigates the personal and professional circumstances that lead academics to become middle managers by drawing on data from life history interviews undertaken with 17 male and female department heads from a range of disciplines, in a post-1992 UK university. The data suggests that experiencing conflict between personal and professional identities, manifested through different socialization experiences over time, can lead to a ‘turning point’ and a decision that affects a person’s career trajectory. Although the results of this study cannot be generalized, the findings may help other individuals and institutions move towards a firmer understanding of the academic who becomes head of department—in relation to theory, practice and research
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