Origin of the diffuse 4–8 keV emission in M 82

We present the first spatially resolved, X-ray spectroscopic study of the 4−8 keV diffuse emission found in the central part of the nearby starburst galaxy M 82 on a few arcsecond scales. The new details that we see allow a number of important conclusions to be drawn on the nature of the hot gas and its origin as well as feedback on the interstellar medium. We use archival data from the Chandra X-ray Observatory with an exposure time of 570 ks. The Fe XXV emission at 6.7 keV, expected from metal-enriched hot gas, is enhanced only in a limited area close to the starburst disc and is weak or almost absent over the rest of the diffuse emission, resulting in spatial variations in equivalent width from < 0.1 keV to 1.9 keV. This shows the presence of non-thermal emission due to inverse Compton scattering of the far-infrared photons by radio emitting cosmic ray electrons. The morphological resemblance between the diffuse X-ray, radio, and far-infrared emission maps support this concept. Our decomposition of the diffuse emission spectrum indicates that ∼70% of the 4−8 keV luminosity originates from the inverse Compton emission. The metal-rich hot gas with a temperature of ≃5 keV makes a minor contribution to the 4−8 keV continuum, but it accounts for the majority of the observed Fe XXV line. This hot gas appears to emerge from the circumnuclear starburst ring and fill the galactic chimneys identified as mid-infrared and radio emission voids. The energetics argument suggests that much of the supernova energy in the starburst site has gone into creating of the chimneys and is transported to the halo. We argue that a hot, rarefied environment produced by strong supernova feedback results in displacing the brightest X-ray and radio supernova remnants which are instead found to reside in giant molecular clouds. We find a faint X-ray source with a radio counterpart, close to the kinematic centre of the galaxy and we carefully examine the possibility that this source is a low-luminosity active galactic nucleus in an advection-dominated accretion flow phase

Molecules as tracers of galaxy evolution: an EMIR survey. I. Presentation of the data and first results

We investigate the molecular gas properties of a sample of 23 galaxies in order to find and test chemical signatures of galaxy evolution and to compare them to IR evolutionary tracers. Observation at 3 mm wavelengths were obtained with the EMIR broadband receiver, mounted on the IRAM 30 m telescope on Pico Veleta, Spain. We compare the emission of the main molecular species with existing models of chemical evolution by means of line intensity ratios diagrams and principal component analysis. We detect molecular emission in 19 galaxies in two 8 GHz-wide bands centred at 88 and 112 GHz. The main detected transitions are the J=1-0 lines of CO, 13CO, HCN, HNC, HCO+, CN, and C2H. We also detect HC3N J=10-9 in the galaxies IRAS 17208, IC 860, NGC 4418, NGC 7771, and NGC 1068. The only HC3N detections are in objects with HCO+/HCN<1 and warm IRAS colours. Galaxies with the highest HC3N/HCN ratios have warm IRAS colours (60/100 {\mu}m>0.8). The brightest HC3N emission is found in IC 860, where we also detect the molecule in its vibrationally excited state.We find low HNC/HCN line ratios (<0.5), that cannot be explained by existing PDR or XDR chemical models. Bright HC3N emission in HCO+-faint objects may imply that these are not dominated by X-ray chemistry. Thus the HCN/HCO+ line ratio is not, by itself, a reliable tracer of XDRs. Bright HC3N and faint HCO+ could be signatures of embedded starformation, instead of AGN activity

A Precision Treatment Model for Internet-Delivered Cognitive Behavioral Therapy for Anxiety and Depression among University Students:A Secondary Analysis of a Randomized Clinical Trial

Importance: Guided internet-delivered cognitive behavioral therapy (i-CBT) is a low-cost way to address high unmet need for anxiety and depression treatment. Scalability could be increased if some patients were helped as much by self-guided i-CBT as guided i-CBT. Objective: To develop an individualized treatment rule using machine learning methods for guided i-CBT vs self-guided i-CBT based on a rich set of baseline predictors. Design, Setting, and Participants: This prespecified secondary analysis of an assessor-blinded, multisite randomized clinical trial of guided i-CBT, self-guided i-CBT, and treatment as usual included students in Colombia and Mexico who were seeking treatment for anxiety (defined as a 7-item Generalized Anxiety Disorder [GAD-7] score of ≥10) and/or depression (defined as a 9-item Patient Health Questionnaire [PHQ-9] score of ≥10). Study recruitment was from March 1 to October 26, 2021. Initial data analysis was conducted from May 23 to October 26, 2022. Interventions: Participants were randomized to a culturally adapted transdiagnostic i-CBT that was guided (n = 445), self-guided (n = 439), or treatment as usual (n = 435). Main Outcomes and Measures: Remission of anxiety (GAD-7 scores of ≤4) and depression (PHQ-9 scores of ≤4) 3 months after baseline. Results: The study included 1319 participants (mean [SD] age, 21.4 [3.2] years; 1038 women [78.7%]; 725 participants [55.0%] came from Mexico). A total of 1210 participants (91.7%) had significantly higher mean (SE) probabilities of joint remission of anxiety and depression with guided i-CBT (51.8% [3.0%]) than with self-guided i-CBT (37.8% [3.0%]; P =.003) or treatment as usual (40.0% [2.7%]; P =.001). The remaining 109 participants (8.3%) had low mean (SE) probabilities of joint remission of anxiety and depression across all groups (guided i-CBT: 24.5% [9.1%]; P =.007; self-guided i-CBT: 25.4% [8.8%]; P =.004; treatment as usual: 31.0% [9.4%]; P =.001). All participants with baseline anxiety had nonsignificantly higher mean (SE) probabilities of anxiety remission with guided i-CBT (62.7% [5.9%]) than the other 2 groups (self-guided i-CBT: 50.2% [6.2%]; P =.14; treatment as usual: 53.0% [6.0%]; P =.25). A total of 841 of 1177 participants (71.5%) with baseline depression had significantly higher mean (SE) probabilities of depression remission with guided i-CBT (61.5% [3.6%]) than the other 2 groups (self-guided i-CBT: 44.3% [3.7%]; P =.001; treatment as usual: 41.8% [3.2%]; P &lt;.001). The other 336 participants (28.5%) with baseline depression had nonsignificantly higher mean (SE) probabilities of depression remission with self-guided i-CBT (54.4% [6.0%]) than guided i-CBT (39.8% [5.4%]; P =.07). Conclusions and Relevance: Guided i-CBT yielded the highest probabilities of remission of anxiety and depression for most participants; however, these differences were nonsignificant for anxiety. Some participants had the highest probabilities of remission of depression with self-guided i-CBT. Information about this variation could be used to optimize allocation of guided and self-guided i-CBT in resource-constrained settings. Trial Registration: ClinicalTrials.gov Identifier: NCT04780542.</p

. 73 Nueva Época (2004) enero-marzo. Antropología. Boletín Oficial del Instituto Nacional de Antropología e Historia

- Educación y violencia en la familia por José Íñigo Aguilar Medina y Ma. Sara Molinari Soriano. - Del mito al rito: territorio simbólico de una comunidad nahua por Nazario A. Sánchez Mastranzo. - El Niñopa: símbolo de identidad cultural xochimilca por Araceli Peralta Flores. - Los chaperos: trabajadores ambientales en los pantanos de Tabasco por Daniel Nahmad Molinari. - Modelo para la construcción del objeto sociológico. Transgresión, distanciamiento y rigurosidad en Bourdieu por Selene Álvarez-Larrauri. - Exploraciones en el “Gran Cúe de Tammapul”, Tula, Tamaulipas por Gustavo A. Ramírez Castilla y Sixto Rodríguez Rosas. - Un plato decorado de Tammapul, Tula, Tamaulipas por Carlos Vanueth Pérez Silva. - Matrícula de Tributos: un análisis por Alejandro Huerta Carrillo y Eugenia Berthier Villaseñor. - Estudio anatómico de la madera de la parte posterior del Retablo de los Reyes de la Catedral Metropolitana por Pablo Torres Soria, Blanca Noval Vilar y Luis Huidobro Salas. - La lectura del pasado y la utopía posible en el siglo XXI por Carlos M. Tur Donatti. - Simposio: Mito y ritual en la periferia septentrional de Mesoamérica por Benigno Casas de la Torre y Juan Pablo Jáuregui. - Lenguas para un pasado, huellas de una nación por Arturo Soberón Mora. - Novedades editoriales del INAH por Benigno Casas de la Torre

BRCA2 Polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Q1Q1Artículo Original1-10Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormonerelated cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10-6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed. Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations