Self-force of a point charge in the space-time of a massive wormhole

We consider the self-potential and the self-force for an electrically charged particle at rest in the massive wormhole space-time. We develop general approach for the renormalization of electromagnetic field of such particle in the static space-times and apply it to the space-time of the wormhole with parameter of the mass, $m$. The self-force is found in manifest form; it is an attractive force. We discus the peculiarities due to massive parameter of the wormhole.Comment: 10 pages, 1 figure text correcte

Профессиональные и образовательные стратегии современных абитуриентов

The article deals with approaches to the understanding of the profession and professional choice in domestic and foreign scientific thought. The key issues of the study of vocational guidance and professional choice are presented in the historical perspective. The interrelation of choosing future life path, professional future and that educational institution, which in the future will allow youth not only to get a profession, but also serves as a launching pad for future career, is considered particularly acute by the end of school before each graduate. Today, the choice of the educational institution by the applicants remains a significant problem for them and in this regard the researchers face the task of characterizing the educational behavior of modern high school students, future applicants.To answer these questions, the staff of Faculty of sociology of the Lomonosov Moscow State University was conducted among senior pupil of Moscow schools. The article presents the results of studies of different years of satisfaction with the level of received education, the motives for choosing the future education of senior pupils, and value orientations of youth. The main factors influencing the choice of the desired level of education and educational institution, as well as the basic model-goals of education used by youth in choosing their life path, were highlighted. The significance of higher education for future applicants and a steady increase in the trend of the spread of consumer behavior of youth, orientation in their life strategies towards success and high material wealth, a certain social status, are confirmed on the basis of the obtained data.В статье рассматриваются подходы к пониманию профессии и профессионального выбора в отечественной и зарубежной научной мысли. Представлены в исторической ретроспективе ключевые вопросы исследования профессиональной ориентации и профессионального выбора. Рассмотрена взаимосвязь выбора своего дальнейшего жизненного пути, своего профессионального будущего и того учебного заведения, которое в дальнейшем позволит не только получить профессию, но и послужит стартовой площадкой для будущей карьеры. Сегодня выбор учебного заведения абитуриентами остается значимой проблемой для них и в связи с этим перед исследователями встает задача дать характеристику образовательного поведения современных старшеклассников, будущих абитуриентов.Для ответа на эти вопросы сотрудниками социологического факультета МГУ имени М.В. Ломоносова было проведено исследование среди старшеклассников московских школ. В статье представлены результаты исследований разных лет удовлетворенности уровнем получаемого образования, мотивов выбора будущего образования школьниками старших классов, ценностных ориентаций молодежи. Были выделены основные факторы, влияющие на выбор уровня желаемого образования и учебного заведения, а также базовые модели-цели получения образования, используемые молодыми людьми при выборе жизненного пути. На основе полученных данных подтверждена значимость высшего образования для будущих абитуриентов и устойчивый рост тенденции распространения потребительского поведения молодежи, ориентации в своих жизненных стратегиях на достижение успеха и высокого материального достатка, определенного социального статуса

СОВРЕМЕННЫЕ ИССЛЕДОВАНИЯ ПЕРСОНАЛА. СОЦИОЛОГИЧЕСКИЙ АНАЛИЗ УПРАВЛЕНИЯ ПЕРСОНАЛОМ И ЗАНЯТОСТЬЮ В ДИССЕРТАЦИОННЫХ ИССЛЕДОВАНИЯХ

The article is based on dissertation papers of PhD and Ph.D. defended in the last decade on the subject of human resource management and employment in general. The article discusses the features of professional development in modern Russia. In view of the development of information technology the need to use knowledge management technologies as a basis for professional development of the individual is highlighted. In this regard, particular attention is paid to the development of the ICT sector personnel, and it is noted the importance of the impact of the transformation of the national education system in the development of personnel in Russia, in particular the transition to a competence-based approach. The article also highlights key factors of motivation of different categories of employees, current models of material and immaterial motivation, special attention is paid to the destructive model of motivation. In the conditions of transitive economy it is important to highlight the features of a new type of employment and the corresponding ways of organizing work in a globalized, postindustrial society. In this regard, special attention is paid to the mechanisms for effective management of employment in the social market economy. Moreover, there is a need of an active employment policy in Russia, resulting in the need to fill labor shortages in the country. One of the most effective ways to solve this problem is the labor migration. Статья основана на диссертациях кандидатов и докторов наук, защищенных в последнее десятилетие по тематике управления персоналом и занятости в целом. В статье рассматриваются особенности профессионального развития персонала в современной России. Ввиду развития информационных технологий подчеркивается необходимость использования технологии управления знаниями в качестве основы профессионального развития личности. В данной связи особое внимание уделяется вопросу развития персонала сферы информационно-коммуникационных технологий (ИКТ), а также отмечается важность влияния трансформации отечественной системы образования на развитие персонала в России, в частности ее переход к компетентностному подходу. В статье также выделяются ключевые факторы трудовой мотивации различных категорий работников, современные модели материальной и нематериальной мотивации персонала, особое внимание уделяется модели деструктивной мотивации. В условиях транзитивной экономики немаловажно выделить особенности занятости нового типа и соответствующие ей способы организации трудовой деятельности в глобализирующемся, постиндустриальном обществе. В связи с этим отдельное внимание уделяется рассмотрению механизмов эффективного управления занятостью в социально-ориентированной рыночной экономике. Помимо этого, отмечается потребность проведения активной политики занятости в России, что обусловливает необходимость восполнения дефицита рабочей силы в стране. В качестве одного из наиболее эффективных способов решения данной проблемы выступает трудовая миграция. 

Differences in expression profiles in malingant melanoma patients according to immunotherapy response

One of the most important branch of modern molecular genetics and biomedicine is the search for predictive markers that help choose the most effective way of treatment, drug and also determine its individual dosage. Among the markers, those that can provide the possibility of using a non­invasive, so­called “liquid biopsy” are considered particularly promising. This method allows the condition of the tumor to be assessed by analyzing the body’s natural fluids, such as blood, urine or saliva. Such studies are most convenient in those cases when it is necessary to monitor the effectiveness of therapy in order to record the time of the onset of resistance of tumor cells, the onset of relapse and to move on to the next line of therapy. In the treatment of aggressive and rapidly became metastatic malignant tumors, such as melanoma, the presence of reliable markers that allow quick and accurate determination of treatment tactics is especially important. Nowadays, there is an increasing number of studies devoted to the search for predictive markers of the effectiveness of immunotherapy. Melanoma is one of the most immunogenic tumors and, as a result, has become a model object for research into and introduction of new approaches to immunotherapy. In this study, we compared two groups of patients with metastatic skin melanoma, with different responses to immunotherapy with blockers of immune control points, to identify new predictive expression biomarkers among microRNAs and mRNAs, and to identify the genes responsible for the occurrence of an objective response to therapy. As a result, the study detected several microRNAs with a significant change in expression level within the tumor tissue of patients responding differently to immunotherapy. Differences in the level of expression of their target genes have also been found, that will allow a more detailed analysis of the molecular mechanisms that determine the sensitivity or resistance of malignant melanoma cells to the immunotherapy. Based on the obtained data, we have proposed expression markers (mRNAs and microRNAs) that can be used as predictors of malignant melanoma tumors to immunotherapy

Knockdown of hexokinase 2 results in a decreased expression level of the glycolytic enzymes PFKP, BPGM, and GPI in RKO cell line

Colorectal cancer (CRC) is one of the most common malignant neoplasms in the world, and is characterized by a high mortality rate. The study of the key aspects of colorectal cancer formation and progression is necessary to develop new approaches to its therapy, as well as to search for new diagnostic, prognostic and predictive biomarkers of CRC. In many types of tumors, one of the key changes in metabolism is the  activation of glycolysis, which is associated with alterations in the expression of the main glycolytic enzymes and regulatory molecules. There is often an increase in hexokinase 2 (HK2) exogenous expression in tumor cells, which makes it a promising target for anticancer therapy. Quantitative expression analysis of 15 genes (GAPDH, ADPGK, ALDOA, ENO3, PFKL, PGK1, PGAM1, PKM2, ENO1, PDK1, PDK3, PFKP, ENO2, GPI, and BPGM), encoding the key glycolysis enzymes, as well as HIF1A gene was carried out in a modified RKO cell line, which constantly expresses the short hairpin RNA (shRNA) for the inhibition of hexokinase 2. A significant decrease in the expression of PFKP, BPGM, and GPI genes both at the mRNA (5­, 86­, and 93­fold, respectively) and protein (2.5­, 3.5­, and 19­fold, respectively) levels was revealed. Probably, the downregulation of GPI and PFKP is associated with a decrease in the amount of their substrates, glucose­6­phosphate and fructose6­phosphate, under the inhibition of hexokinase 2. Nevertheless, the cause of a decreased mRNA level of these three enzymes, while the expression level of other glycolytic participants is constant, requires further investigation

SEPARATION OF CESIUM AND ALUMINUM BY CATION-EXCHANGER PUROLITE C-160

The possibility of cesium separation from aluminum during conversion of waste of catalysts processing by use of сation-exchanger Purolite C-160 at different pH was studied. The separation of these elements was not possible in the pH range of (2,0 – 10,0)

TUNGSTEN SORPTION BY ANION-EXCHANGER PUROLITE A830

Sorption characteristics of anion-exchanger Purolite A830 by W from Na2WO3 solutions with pH 2.5-3.0 were determined. The value of dynamic exchange capacity of resin at full saturation was 458,51 kg W m-3. The 15% ammonia water solution was most effective eluent for W

Aspergillus Myosin-V Supports Polarized Growth in the Absence of Microtubule-Based Transport

In the filamentous fungus Aspergillus nidulans, both microtubules and actin filaments are important for polarized growth at the hyphal tip. Less clear is how different microtubule-based and actin-based motors work together to support this growth. Here we examined the role of myosin-V (MYOV) in hyphal growth. MYOV-depleted cells form elongated hyphae, but the rate of hyphal elongation is significantly reduced. In addition, although wild type cells without microtubules still undergo polarized growth, microtubule disassembly abolishes polarized growth in MYOV-depleted cells. Thus, MYOV is essential for polarized growth in the absence of microtubules. Moreover, while a triple kinesin null mutant lacking kinesin-1 (KINA) and two kinesin-3s (UNCA and UNCB) undergoes hyphal elongation and forms a colony, depleting MYOV in this triple mutant results in lethality due to a severe defect in polarized growth. These results argue that MYOV, through its ability to transport secretory cargo, can support a significant amount of polarized hyphal tip growth in the absence of any microtubule-based transport. Finally, our genetic analyses also indicate that KINA (kinesin-1) rather than UNCA (kinesin-3) is the major kinesin motor that supports polarized growth in the absence of MYOV

THE CHOICE OF IONIT FORM FOR SORPTION OF LANTANUM AND CERIUM FROM SULFURIC ACID SOLUTIONS

The choice of ionic form of cation exchanger Dowex Marathon C for effective sorption of La and Ce from sulfuric acid solutions was carried out. The ammonium form of cation exchanger was chosen because of high values of sorption of both elements