Quantum ergodicity for restrictions to hypersurfaces

Quantum ergodicity theorem states that for quantum systems with ergodic classical flows, eigenstates are, in average, uniformly distributed on energy surfaces. We show that if N is a hypersurface in the position space satisfying a simple dynamical condition, the restrictions of eigenstates to N are also quantum ergodic.Comment: 22 pages, 1 figure; revised according to referee's comments. To appear in Nonlinearit

On the phenomenology of a Z' coupling only to third-family fermions

The phenomenology of an additional U(1) neutral gauge boson Z' coupled to the third family of fermions is discussed. One might expect such a particle to contribute to processes where taus, b and t quarks are produced. Precision data from LEP1 put severe constraints on the mixing and heavy-boson mass. We find that the effects of such a particle could not be observed at hadronic colliders, be it at the Tevatron or the LHC, because of the QCD background. At LEP2 and future e^+e^- linear colliders, one could instead hope to observe such effects, in particular for b\bar b final states.Comment: 36 pages, LaTeX, including 12 figure

Analysis of Implementation of the Requirements for Provision of Biological Safety at a Potentially Hazardous Facility

Discussed are the problems of implementation of requirements for the provision of biological safety at a potentially hazardous biological facility by the example of Federal Budgetary Institution of Science “State Scientific Center of Applied Microbiology and Biotechnology” of the Rospotrebnadzor. Identified are the necessary and sufficient organizational-andpreventive and control measures and procedures on management of works with microorganisms of the I-IV groups of pathogenicity (hazard) in isolated labs of the Center. Issues associated with exploitation of biological safety engineering systems and assessment of their protective efficiency, problems of medical support of the activities and response to the emergency situations of biological character with the involvement of doctors from a specialized medical wing of the Federal Medical-Biological Agency of the Russian Federation, serving the facility on a constant basis, are analyzed. Determined have been approaches to and principles of establishing the requirements for the system of biological safety at a potentially hazardous biological facility taking into account all the range of biological risks when working with microorganisms. Complex approach and realization of appropriate necessary measures in the sphere of biological safety provision, creating an environment for the reduction of biological risks up to acceptable level while working with pathogenic microorganisms, can be an effective solution of the problem on the whole

Asymptotic distribution of quasi-normal modes for Kerr-de Sitter black holes

We establish a Bohr-Sommerfeld type condition for quasi-normal modes of a slowly rotating Kerr-de Sitter black hole, providing their full asymptotic description in any strip of fixed width. In particular, we observe a Zeeman-like splitting of the high multiplicity modes at a=0 (Schwarzschild-de Sitter), once spherical symmetry is broken. The numerical results presented in Appendix B show that the asymptotics are in fact accurate at very low energies and agree with the numerical results established by other methods in the physics literature. We also prove that solutions of the wave equation can be asymptotically expanded in terms of quasi-normal modes; this confirms the validity of the interpretation of their real parts as frequencies of oscillations, and imaginary parts as decay rates of gravitational waves.Comment: 66 pages, 6 figures; journal version (to appear in Annales Henri Poincar\'e

Peculiarities of the Conjugative pSa Plasmid Transfer from <I>Escherichia coli</I> into <I>Francisella tularensis</I>

per a recipient cell). pSa′ plasmid molds several topological shapes with variable electrophoretic mobility in E. coli C600, while in tularemia microbe, this plasmid has only one shape. After the transfer of the plasmid from E. coli cells into F. tularensis cells each individual clone of tularemia microbe possesses a plasmid which differs in its electrophoretic mobility from plasmids of other clones

Development and Testing of Monoclonal Antibodies-Based Diagnostic Preparation for <i>Bacillus anthracis</i> Spores Detection Using Latex Agglutination Method

Immobilization of anti-B. anthracis monoclonal antibodies (MAbs) on latex microparticles was studied, the optimal load of these MAbs was determined to be 20 µg for 50 µl of the stock latex suspension. The highest sensitivity of latex agglutination test was observed for 1E6 MAbs. Latex suspensions with immobilized MAbs were lyophilized. Their sensitivity and specificity were shown to be highly competitive with those of the stock liquid latex suspension. Latex diagnosticum for Bacillus anthracis spores detection was constructed on the basis of these lyophilized reagents, developed and approved was the regulatory documentation that included their application instructions and technical specifications. Carried out were inter-laboratory and commission tests of experimental prototypes of the designed latex diagnosticum. These preparations demonstrated high sensitivity (from 1·105 to 2·106 spores/ml and even more) and specificity (absence of cross-reactions with spores of different species of sporogenous bacilli at concentration of 108 spores/ml)

Elite athletes' genetic predisposition for altered risk of complex metabolic traits

BACKGROUND: Genetic variants may predispose humans to elevated risk of common metabolic morbidities such as obesity and Type 2 Diabetes (T2D). Some of these variants have also been shown to influence elite athletic performance and the response to exercise training. We compared the genotype distribution of five genetic Single Nucleotide Polymorphisms (SNPs) known to be associated with obesity and obesity co-morbidities (IGF2BP2 rs4402960, LPL rs320, LPL rs328, KCJN rs5219, and MTHFR rs1801133) between athletes (all male, n = 461; endurance athletes n = 254, sprint/power athletes n = 207), and controls (all male, n = 544) in Polish and Russian samples. We also examined the association between these SNPs and the athletes’ competition level (‘elite’ and ‘national’ level). Genotypes were analysed by Single-Base Extension and Real-Time PCR. Multinomial logistic regression analyses were conducted to assess the association between genotypes and athletic status/competition level. RESULTS: IGF2BP2 rs4402960 and LPL rs320 were significantly associated with athletic status; sprint/power athletes were twice more likely to have the IGF2BP2 rs4402960 risk (T) allele compared to endurance athletes (OR = 2.11, 95% CI = 1.03-4.30, P <0.041), and non-athletic controls were significantly less likely to have the T allele compared to sprint/power athletes (OR = 0.62, 95% CI =0.43-0.89, P <0.0009). The control group was significantly more likely to have the LPL rs320 risk (G) allele compared to endurance athletes (OR = 1.26, 95% CI = 1.05-1.52, P <0.013). Hence, endurance athletes were the “protected” group being significantly (p < 0.05) less likely to have the risk allele compared to sprint/power athletes (IGF2BP2 rs4402960) and significantly (p < 0.05) less likely to have the risk allele compared to controls (LPL rs320). The other 3 SNPs did not show significant differences between the study groups. CONCLUSIONS: Male endurance athletes are less likely to have the metabolic risk alleles of IGF2BP2 rs4402960 and LPL rs320, compared to sprint/power athletes and controls, respectively. These results suggest that some SNPs across the human genome have a dual effect and may predispose endurance athletes to reduced risk of developing metabolic morbidities, whereas sprint/power athletes might be predisposed to elevated risk

Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA Gene

Deletion of recA gene in Francisella tularensis 15/10 genome leads to the increase in its sensitivity to ultraviolet irradiation, reduction of the homologous recombination capacity, and a slight decline of virulence for mice. Efficacy of Francisella tularensis 15/10ΔrecA reproduction within microphage-like cells, its resistance to normal rabbit serum, and protective properties on the mouse model of tularemia are the same as in original Francisella tularensis 15/10

Study of the UV Irradiation and Nalidicsic Acid Effect on the RecA-protein Induction in <i>Francisella tularensis</i> 15/10 Cells

Studied is the UV irradiation and nalidicsic acid effect on the RecA-protein synthesis in Francisella tularensis 15/10 cells. Obtained is the specific murine serum to the recombinant RecA-protein. The results of immunoblotting with this specific serum demonstrate that the amount of RecA-protein in Francisella tularensis 15/10 cells is not increased after the exposure to these damaging factors

Alteration of Effector Activity of T-Lymphocytes in Mice Immunized against Tularemia, Using <I>in vitro</I> Stimulation by Tularin

lymphocytes) isolated from mice, immunized against tularemia. Put forward is the proposition to use tularin in serological surveys and reactions in vitro for identification of postinfectious or postvaccinal immunity to tularemia