Abundances in Stars from the Red Giant Branch Tip to the Near the Main Sequence in M71: I. Sample Selection, Observing Strategy and Stellar Parameters

We present the sample for an abundance analysis of 25 members of M71 with luminosities ranging from the red giant branch tip to the upper main sequence. The spectra are of high dispersion and of high precision. We describe the observing strategy and determine the stellar parameters for the sample stars using both broad band colors and fits of H$\alpha$ profiles. The derived stellar parameters agree with those from the Yale$^2$ stellar evolutionary tracks to within 50 -- 100K for a fixed log g, which is within the level of the uncertainties.Comment: Minor changes to conform to version accepted for publication, with several new figures (Paper 1 of a pair

The GOAL study: a prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes

Factor V Leiden (FVL) and ABO(H) blood groups are the common influences on haemostasis and retrospective studies have linked FVL with pregnancy complications. However, only one sizeable prospective examination has taken place. As a result, neither the impact of FVL in unselected subjects, any interaction with ABO(H) in pregnancy, nor the utility of screening for FVL is defined. A prospective study of 4250 unselected pregnancies was carried out. A venous thromboembolism (VTE) rate of 1·23/1000 was observed, but no significant association between FVL and pre-eclampsia, intra-uterine growth restriction or pregnancy loss was seen. No influence of FVL and/or ABO(H) on ante-natal bleeding or intra-partum or postpartum haemorrhage was observed. However, FVL was associated with birth-weights >90th centile [odds ratio (OR) 1·81; 95% confidence interval (CI<sub>95</sub>) 1·04–3·31] and neonatal death (OR 14·79; CI<sub>95</sub> 2·71–80·74). No association with ABO(H) alone, or any interaction between ABO(H) and FVL was observed. We neither confirmed the protective effect of FVL on pregnancy-related blood loss reported in previous smaller studies, nor did we find the increased risk of some vascular complications reported in retrospective studies

Convection, Thermal Bifurcation, and the Colors of A stars

Broad-band ultraviolet photometry from the TD-1 satellite and low dispersion spectra from the short wavelength camera of IUE have been used to investigate a long-standing proposal of Bohm-Vitense that the normal main sequence A- and early-F stars may divide into two different temperature sequences: (1) a high temperature branch (and plateau) comprised of slowly rotating convective stars, and (2) a low temperature branch populated by rapidly rotating radiative stars. We find no evidence from either dataset to support such a claim, or to confirm the existence of an "A-star gap" in the B-V color range 0.22 <= B-V <= 0.28 due to the sudden onset of convection. We do observe, nonetheless, a large scatter in the 1800--2000 A colors of the A-F stars, which amounts to ~0.65 mags at a given B-V color index. The scatter is not caused by interstellar or circumstellar reddening. A convincing case can also be made against binarity and intrinsic variability due to pulsations of delta Sct origin. We find no correlation with established chromospheric and coronal proxies of convection, and thus no demonstrable link to the possible onset of convection among the A-F stars. The scatter is not instrumental. Approximately 0.4 mags of the scatter is shown to arise from individual differences in surface gravity as well as a moderate spread (factor of ~3) in heavy metal abundance and UV line blanketing. A dispersion of ~0.25 mags remains, which has no clear and obvious explanation. The most likely cause, we believe, is a residual imprecision in our correction for the spread in metal abundances. However, the existing data do not rule out possible contributions from intrinsic stellar variability or from differential UV line blanketing effects owing to a dispersion in microturbulent velocity.Comment: 40 pages, 14 figures, 1 table, AAS LaTex, to appear in The Astrophysical Journa

Mergers of close primordial binaries

We study the production of main sequence mergers of tidally-synchronized primordial short-period binaries. The principal ingredients of our calculation are the angular momentum loss rates inferred from the spindown of open cluster stars and the distribution of binary properties in young open clusters. We compare our results with the expected number of systems that experience mass transfer in post-main sequence phases of evolution and compute the uncertainties in the theoretical predictions. We estimate that main-sequence mergers can account for the observed number of single blue stragglers in M67. Applied to the blue straggler population, this implies that such mergers are responsible for about one quarter of the population of halo blue metal poor stars, and at least one third of the blue stragglers in open clusters for systems older than 1 Gyr. The observed trends as a function of age are consistent with a saturated angular momentum loss rate for rapidly rotating tidally synchronized systems. The predicted number of blue stragglers from main sequence mergers alone is comparable to the number observed in globular clusters, indicating that the net effect of dynamical interactions in dense stellar environments is to reduce rather than increase the blue straggler population. A population of subturnoff mergers of order 3-4% of the upper main sequence population is also predicted for stars older than 4 Gyr, which is roughly comparable to the small population of highly Li-depleted halo dwarfs. Other observational tests are discussed.Comment: number of pages depends on font, margins, columns etc (58 with given format), 14 figures, submitted to the Astrophysical Journa

Functional neuroimaging effects of recently discovered genetic risk loci for schizophrenia and polygenic risk profile in five RDoC subdomains

Recently, 125 loci with genome-wide support for association with schizophrenia were identified. We investigated the impact of these variants and their accumulated genetic risk on brain activation in five neurocognitive domains of the Research Domain Criteria (working memory, reward processing, episodic memory, social cognition and emotion processing). In 578 healthy subjects we tested for association (i) of a polygenic risk profile score (RPS) including all single-nucleotide polymorphisms (SNPs) reaching genome-wide significance in the recent genome-wide association studies (GWAS) meta-analysis and (ii) of all independent genome-wide significant loci separately that showed sufficient distribution of all allelic groups in our sample (105 SNPs). The RPS was nominally associated with perigenual anterior cingulate and posterior cingulate/precuneus activation during episodic memory (PFWE(ROI)=0.047) and social cognition (PFWE(ROI)=0.025), respectively. Single SNP analyses revealed that rs9607782, located near EP300, was significantly associated with amygdala recruitment during emotion processing (PFWE(ROI)=1.63 × 10−4, surpassing Bonferroni correction for the number of SNPs). Importantly, this association was replicable in an independent sample (N=150; PFWE(ROI)<0.025). Other SNP effects previously associated with imaging phenotypes were nominally significant, but did not withstand correction for the number of SNPs tested. To assess whether there was true signal within our data, we repeated single SNP analyses with 105 randomly chosen non-schizophrenia-associated variants, observing fewer significant results and lower association probabilities. Applying stringent methodological procedures, we found preliminary evidence for the notion that genetic risk for schizophrenia conferred by rs9607782 may be mediated by amygdala function. We critically evaluate the potential caveats of the methodological approaches employed and offer suggestions for future studies

A Consistency Test of Spectroscopic Gravities for Late-Type Stars

Chemical analyses of late-type stars are usually carried out following the classical recipe: LTE line formation and homogeneous, plane-parallel, flux-constant, and LTE model atmospheres. We review different results in the literature that have suggested significant inconsistencies in the spectroscopic analyses, pointing out the difficulties in deriving independent estimates of the stellar fundamental parameters and hence,detecting systematic errors. The trigonometric parallaxes measured by the HIPPARCOS mission provide accurate appraisals of the stellar surface gravity for nearby stars, which are used here to check the gravities obtained from the photospheric iron ionization balance. We find an approximate agreement for stars in the metallicity range -1 <= [Fe/H] <= 0, but the comparison shows that the differences between the spectroscopic and trigonometric gravities decrease towards lower metallicities for more metal-deficient dwarfs (-2.5 <= [Fe/H] <= -1.0), which casts a shadow upon the abundance analyses for extreme metal-poor stars that make use of the ionization equilibrium to constrain the gravity. The comparison with the strong-line gravities derived by Edvardsson (1988) and Fuhrmann (1998a) confirms that this method provides systematically larger gravities than the ionization balance. The strong-line gravities get closer to the physical ones for the stars analyzed by Fuhrmann, but they are even further away than the iron ionization gravities for the stars of lower gravities in Edvardsson's sample. The confrontation of the deviations of the iron ionization gravities in metal-poor stars reported here with departures from the excitation balance found in the literature, show that they are likely to be induced by the same physical mechanism(s).Comment: AAS LaTeX v4.0, 35 pages, 10 PostScript files; to appear in The Astrophysical Journa

Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates

In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing so via means of systemic analysis pivotal to inform pathophysiological conditions associated with mitochondrial deficiency. With the goal to decipher the role of the ATPase inhibitory factor 1 (IF1) in brain development, we employed the zebrafish as elected model reporting that the Atpif1a−/− zebrafish mutant, pinotage (pnttq209), which lacks one of the two IF1 paralogous, exhibits visual impairment alongside increased apoptotic bodies and neuroinflammation in both brain and retina. This associates with increased processing of the dynamin-like GTPase optic atrophy 1 (OPA1), whose ablation is a direct cause of inherited optic atrophy. Defects in vision associated with the processing of OPA1 are specular in Atpif1−/− mice thus confirming a regulatory axis, which interlinks IF1 and OPA1 in the definition of mitochondrial fitness and specialised brain functions. This study unveils a functional relay between IF1 and OPA1 in central nervous system besides representing an example of how the zebrafish model could be harnessed to infer the activity of mitochondrial proteins during development