CT-based tumour response criteria compared after combined treatment for liver metastases of colorectal cancer

open6noPurpose: The aim of this analysis is to compare different tumour response criteria (TRC) after chemotherapy combined with bevacizumab in liver metastases from colorectal cancer (mCRC) to ascertain the best early prognostic indicator of response. Methods and Materials: 103 target liver metastases from 65 mCRC patients treated with chemoterapy plus bevacizumab were examined at the Istituto Oncologico Veneto IOV-IRCSS (March 2008-January 2013). All patients had baseline CT and at least one follow-up scan. Tumour response was retrospectively analyzed by two radiologists using RECIST1.1, modified Choi, and Chun morphologic criteria. Tumour response, classified as good (complete or partial response) or poor (stable or progressive disease), was compared with progression-free survival (PFS) at first follow-up (t1) and time of best response. Interobserver agreement and concordance between TRC were measured. Results: At t1, 32.31% showed a good response according to RECIST1.1 (median PFS 11.1), 84.62% according to Choi (median PFS 10.8). These percentages rose to 49.23% (median PFS 12.1) and 87.69% (median PFS 10.8), respectively, at the time of best response. According to Chun, 67.69% showed a good response at the time of best response (median PFS 10.8). The Choi criteria detected a higher proportion of good responders at t1, showing a better correlation with PFS; all methods correlated with PFS at the time of best response. Conclusion: The Choi criteria proved more consistent in the early detection of response in mCRC treated with chemotherapy plus bevacizumab, underscoring the importance of using these criteria in the early assessment of response to combined treatment.openopenVarotto, A.; Di Grazia, L.; Aliberti, C.; Bergamo, F.; Nardin, M.; Pomerri, F.Varotto, A.; Di Grazia, L.; Aliberti, C.; Bergamo, F.; Nardin, M.; Pomerri, Fabi

Measurements of Shear Elasticity of agarose gels using a surface-wave technique

ゲルに数百Hz程度の表面波を励起すると弾性表面波と擬似表面張力波が伝搬するが、ゾルーゲル転移温度から十分離れたところでは弾性表面波が支配的に伝搬する。約20℃、濃度0.3-1%のアガロースゲルに200-1000Hzのバースト波状表面波を伝搬させ、その変位をレーザ光偏向で検出することにより、表面波速度・吸収を測定した。さらにずれ弾性率の実部、虚部を計算し、G'=10^3-10^4 Pa, G"=10^2-10^3 Paの値を得た。これらの値は低周波の粘弾性実験による結果と一致した

Comment on "Theory of collisions between an atom and a diatomic molecule in the body-fixed coordinate system"

It is shown that the phase factor i^(J+j+I) omitted in a theory of atom‐diatom monreactive scattering formulated by schatz and kupperman but included in the Choi, Poe, and Tang theory does not lead to errors in the analysis of te (H,H_2) system

Social entrepreneurship

Review of: Choi, David Y and Gray, Edmund (2010), Values-Centered Entrepreneurs and Their Companies, Routledge, ISBN 978-041599761

Asymptotic behavior of the loss probability for an M/G/1/N queue with vacations

In this paper, asymptotic properties of the loss probability are considered for an M/G/1/N queue with server vacations and exhaustive service discipline, denoted by an M/G/1/N -(V, E)-queue. Exact asymptotic rates of the loss probability are obtained for the cases in which the traffic intensity is smaller than, equal to and greater than one, respectively. When the vacation time is zero, the model considered degenerates to the standard M/G/1/N queue. For this standard queueing model, our analysis provides new or extended asymptotic results for the loss probability. In terms of the duality relationship between the M/G/1/N and GI/M/1/N queues, we also provide asymptotic properties for the standard GI/M/1/N model