592 research outputs found
European surveillance of infections in cancer patients - ESIC
Major advances in cancer therapy result from development of multidrug chemotherapy regimens. Besides death from tumor progression, infections are currently one of the major causes of mortality and morbidity. Because of the risk of complications and mortality, the treatment for febrile neutropenia is admission to hospital and administration of broad-spectrum antibiotics. Response rates of initial antimicrobial treatment vary considerably (40-92%). Due to the heterogeneity of populations in randomized studies, comparison of efficacy and identification of risk factors is limited. This is the main reason why the European Society of Biomodulation and Chemotherapy (ESBiC) is conducting a surveillance study that concentrates more on the evaluation of risk factors than on the therapeutic outcome of prospective randomized antimicrobial regimens: European Surveillance of Infections in Cancer Patients (ESIC). The present contribution is to determine which cancer patients are at low risk for fever, and can benefit from first-line treatment with treatment options such as monotherapy as well as on an outpatient basis
Syntaxin 16 is a master recruitment factor for cytokinesis
Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and abscission, respectively. However, it is not clear how either of these complexes is targeted to the midbody and whether their delivery is coordinated. The trafficking of membrane vesicles between different intracellular organelles involves the formation of soluble N-ethylmaleiÂmide–sensitive factor attachment protein receptor (SNARE) complexes. Although membrane traffic is known to play an important role in cytokinesis, the contribution and identity of intracellular SNAREs to cytokinesis remain unclear. Here we demonstrate that syntaxin 16 is a key regulator of cytokinesis, as it is required for recruitment of both recycling endosome–associated Exocyst and ESCRT machinery during late telophase, and therefore that these two distinct facets of cytokinesis are inextricably linked
Light-cone distribution amplitudes of the baryon octet
We present results of the first ab initio lattice QCD calculation of the
normalization constants and first moments of the leading twist distribution
amplitudes of the full baryon octet, corresponding to the small transverse
distance limit of the associated S-wave light-cone wave functions. The P-wave
(higher twist) normalization constants are evaluated as well. The calculation
is done using flavors of dynamical (clover) fermions on lattices of
different volumes and pion masses down to 222 MeV. Significant SU(3) flavor
symmetry violation effects in the shape of the distribution amplitudes are
observed.Comment: Update to the version published in JHE
An accurate determination of the Avogadro constant by counting the atoms in a 28Si crystal
The Avogadro constant links the atomic and the macroscopic properties of
matter. Since the molar Planck constant is well known via the measurement of
the Rydberg constant, it is also closely related to the Planck constant. In
addition, its accurate determination is of paramount importance for a
definition of the kilogram in terms of a fundamental constant. We describe a
new approach for its determination by "counting" the atoms in 1 kg
single-crystal spheres, which are highly enriched with the 28Si isotope. It
enabled isotope dilution mass spectroscopy to determine the molar mass of the
silicon crystal with unprecedented accuracy. The value obtained, 6.02214084(18)
x 10^23 mol^-1, is the most accurate input datum for a new definition of the
kilogram.Comment: 4 pages, 5 figures, 3 table
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