Exploiting the Brønsted acidity of phosphinecarboxamides for the synthesis of new phosphides and phosphines

International audienc

Characteristics, practice patterns, and outcomes in patients with acute hypertension: European registry for Studying the Treatment of Acute hyperTension (Euro-STAT)

Although effective strategies are available for the management of chronic hypertension, less is known about treating patients with acute, severe elevations in blood pressure. Using data from the European registry for Studying the Treatment of Acute hyperTension (Euro-STAT), we sought to evaluate 'real-life' management practices and outcomes in patients who received intravenous antihypertensive therapy to treat an episode of acute hypertension.Journal Articleinfo:eu-repo/semantics/publishe

Étude de la variation au cours d'une période de la constante diélectrique complexe d'une cellule électroluminescente

Nous avons calculé, à partir de données expérimentales sur les courants traversant une cellule électroluminescente, les valeurs instantanées de la « constante » diélectrique complexe. Les variations de celle-ci sur une période ont pu être mises en relation avec celles de la luminance et de la puissance absorbée, permettant d'envisager un bilan énergétique de la cellule

Étude de la variation au cours d'une période de la constante diélectrique complexe d'une cellule électroluminescente

We have calculated from experimental data on electrical currents, in an electroluminescent cell, the values of the complex dielectric constant. Its variations during a period are connected to brightness and absorbed power variations, permit t-ing one to do an energy balance of the cell.Nous avons calculé, à partir de données expérimentales sur les courants traversant une cellule électroluminescente, les valeurs instantanées de la « constante » diélectrique complexe. Les variations de celle-ci sur une période ont pu être mises en relation avec celles de la luminance et de la puissance absorbée, permettant d'envisager un bilan énergétique de la cellule

Pharmacological blockade of muscle afferents and perception of effort:A systematic review with meta-analysis

Background The perception of effort provides information on task difficulty and influences physical exercise regulation and human behavior. This perception differs from other-exercise related perceptions such as pain. There is no consensus on the role of group III/IV muscle afferents as a signal processed by the brain to generate the perception of effort. Objective The aim of this meta-analysis was to investigate the effect of pharmacologically blocking muscle afferents on the perception of effort. Methods Six databases were searched to identify studies measuring the ratings of perceived effort during physical exercise, with and without pharmacological blockade of muscle afferents. Articles were coded based on the operational measurement used to distinguish studies in which perception of effort was assessed specifically (effort dissociated) or as a composite experience including other exercise-related perceptions (effort not dissociated). Articles that did not provide enough information for coding were assigned to the unclear group. Results The effort dissociated group (n = 6) demonstrated a slight increase in ratings of perceived effort with reduced muscle afferent feedback (standard mean change raw, 0.39; 95% confidence interval 0.13-0.64). The group effort not dissociated (n = 2) did not reveal conclusive results (standard mean change raw, - 0.29; 95% confidence interval - 2.39 to 1.8). The group unclear (n = 8) revealed a slight ratings of perceived effort decrease with reduced muscle afferent feedback (standard mean change raw, - 0.27; 95% confidence interval - 0.50 to - 0.04). Conclusions The heterogeneity in results between groups reveals that the inclusion of perceptions other than effort in its rating influences the ratings of perceived effort reported by the participants. The absence of decreased ratings of perceived effort in the effort dissociated group suggests that muscle afferent feedback is not a sensory signal for the perception of effort

Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis : The way forward

Progressive cystic fibrosis (CF) lung disease is the main cause of mortality in CF patients. CF lung disease starts in early childhood. With current standards of care, respiratory function remains largely normal in children and more sensitive outcome measures are needed to monitor early CF lung disease. Chest CT is currently the most sensitive imaging modality to monitor pulmonary structural changes in children and adolescents with CF. To quantify structural lung disease reliably among multiple centres, standardisation of chest CT protocols is needed. SCIFI CF (Standardised Chest Imaging Framework for Interventions and Personalised Medicine in CF) was founded to characterise chest CT image quality and radiation doses among 16 participating European CF centres in 10 different countries. We aimed to optimise CT protocols in children and adolescents among several CF centres. A large variety was found in CT protocols, image quality and radiation dose usage among the centres. However, the performance of all CT scanners was found to be very similar, when taking spatial resolution and radiation dose into account. We conclude that multicentre standardisation of chest CT in children and adolescents with CF can be achieved for future clinical trials