Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW.

Purpose: B-cell lymphomas must acquire resistance to apoptosis during their development. We recently discovered BCLW, an antiapoptotic BCL2 family member thought only to contribute to spermatogenesis, was overexpressed in diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. To gain insight into the contribution of BCLW to B-cell lymphomas and its potential to confer resistance to BCL2 inhibitors, we investigated the expression of BCLW and the other antiapoptotic BCL2 family members in six different B-cell lymphomas. Experimental Design: We performed a large-scale gene expression analysis of datasets comprising approximately 2,300 lymphoma patient samples, including non-Hodgkin and Hodgkin lymphomas as well as indolent and aggressive lymphomas. Data were validated experimentally with qRT-PCR and IHC. Results: We report BCLW is significantly overexpressed in aggressive and indolent lymphomas, including DLBCL, Burkitt, follicular, mantle cell, marginal zone, and Hodgkin lymphomas. Notably, BCLW was preferentially overexpressed over that of BCL2 and negatively correlated with BCL2 in specific lymphomas. Unexpectedly, BCLW was overexpressed as frequently as BCL2 in follicular lymphoma. Evaluation of all five antiapoptotic BCL2 family members in six types of B-cell lymphoma revealed that BCL2, BCLW, and BCLX were consistently overexpressed, whereas MCL1 and A1 were not. In addition, individual lymphomas frequently overexpressed more than one antiapoptotic BCL2 family member. Conclusions: Our comprehensive analysis indicates B-cell lymphomas commonly select for BCLW overexpression in combination with or instead of other antiapoptotic BCL2 family members. Our results suggest BCLW may be equally as important in lymphomagenesis as BCL2 and that targeting BCLW in lymphomas should be considered. ©2017 AACR

Efficient Scheme for Perfect Collective Einstein-Podolsky-Rosen Steering

A practical scheme for the demonstration of perfect one-sided device-independent quantum secret sharing is proposed. The scheme involves a three-mode optomechanical system in which a pair of independent cavity modes is driven by short laser pulses and interact with a movable mirror. We demonstrate that by tuning the laser frequency to the blue (anti-Stokes) sideband of the average frequency of the cavity modes, the modes become mutually coherent and then may collectively steer the mirror mode to a perfect Einstein-Podolsky-Rosen state. The scheme is shown to be experimentally feasible, it is robust against the frequency difference between the modes, mechanical thermal noise and damping, and coupling strengths of the cavity modes to the mirror.Comment: 9 pages, 4 figure

Adiabatic Creation of Atomic Squeezing in Dark States vs. Decoherences

We study the multipartite correlations of the multi-atom dark states, which are characterized by the atomic squeezing beyond the pairwise entanglement. It is shown that, in the photon storage process with atomic ensemble via electromagnetically induced transparency (EIT) mechanism, the atomic squeezing and the pairwise entanglement can be created by adiabatically manipulating the Rabi frequency of the classical light field on the atomic ensemble. We also consider the sudden death for the atomic squeezing and the pairwise entanglement under various decoherence channels. An optimal time for generating the greatest atomic squeezing and pairwise entanglement is obtained by studying in details the competition between the adiabatic creation of quantum correlation in the atomic ensemble and the decoherence that we describe with three typical decoherence channels.Comment: 11 pages, 13 figure

KALwEN: A New Practical and Interoperable Key Management Scheme for Body Sensor Networks

Key management is the pillar of a security architecture. Body sensor networks(BSNs) pose several challenges -- some inherited from wireless sensor networks(WSNs), some unique to themselves -- that require a new key management scheme to be tailor-made. The challenge is taken on, and the result is KALwEN, a new lightweight scheme that combines the best-suited cryptographic techniques in a seamless framework. KALwEN is user-friendly in the sense that it requires no expert knowledge of a user, and instead only requires a user to follow a simple set of instructions when bootstrapping or extending a network. One of KALwEN's key features is that it allows sensor devices from different manufacturers, which expectedly do not have any pre-shared secret, to establish secure communications with each other. KALwEN is decentralized, such that it does not rely on the availability of a local processing unit (LPU). KALwEN supports global broadcast, local broadcast and neighbor-to-neighbor unicast, while preserving past key secrecry and future key secrecy. The fact that the cryptographic protocols of KALwEN have been formally verified also makes a convincing case

A deep level transient spectroscopy study of electron irradiation induced deep levels in p-type 6H–SiC

1.7 MeV electron irradiation-induced deep levels in p-type 6H–SiC have been studied using deep level transient spectroscopy. Two deep hole traps are observed, which are located at EV+0.55 eV and EV+0.78 eV. They have been identified as two different defects because they have different thermal behaviors. These defects at EV+0.55 eV and EV+0.78 eV are annealed out at 500–200 °C, respectively, and are different from the main defects E1/E2, Z1/Z2 observed in electron irradiated n-type 6H–SiC. This indicates that new defects have been formed in p-type 6H–SiC during electron irradiation. ©1999 American Institute of Physics.published_or_final_versio