The Co-ordination of Swimmeret Movements in the Crayfish, Procambarus Clarkii (Girard)

1. Electrical activity recorded in the first roots of the abdominal nerve cord show bursts of activity which accompany rhythmic movements of the swimmerets. These bursts persist when a root is cut distal to the electrodes. 2. Proprioceptive impulses have been recorded from the distal portion of these nerves during passive movements of the swimmerets. They have also been recorded in the connectives during both passive and active movements. 3. Cutting all second and third roots of the abdominal ganglia does not interfere with the rhythmic swimmeret movements of the isolated abdomen. Rhythmic efferent bursts persist in first roots even when only a single first root remains intact in such a preparation. 4. Intermittent bursts are also found in the first roots of a completely isolated cord but their pattern, frequency and phase relationships differ from those recorded in the same roots before isolation was completed. Such bursts are very rare in second and third roots. 5. Stimulation of small bundles of fibres in the circumoesophageal commissure produces well-defined inhibitory and excitatory effects on the discharge of single units in the first roots. 6. One specific bundle found in many preparations, when stimulated at 50/sec., caused a tonic retraction of all the swimmerets which then began to beat rhythmically and continued to do so when stimulation was discontinued. 7. Intermittent bursts in the first roots took place with correct phasing during this stimulation even when the abdominal ganglia were isolated except for their connexion with the last thoracic ganglion. Again, such bursts were absent in the second and third roots. 8. It is concluded that both the inflow from peripheral proprioceptors and intrinsic properties of the central ganglia play essential parts in the co-ordination of the metachronal movements of the swimmerets

Neuronal Pathways and Synaptic Connexions in the Abdominal Cord of the Crayfish

1. An investigation has been made into the function and distribution of nerve fibres in the abdominal ganglion chain and its roots in the crayfish, Procambarus clarkii, by leading off action potentials from small prepared bundles following sensory stimulation. 2 .The sensory fields belonging to the first and second roots of each abdominal ganglion were determined, and the antero-posterior pathway of sensory fibres within the cord noted. It was found that the primary sensory fibres of the dorsal muscle receptor organs, entering through the second root, send out an anterior branch to the brain and a posterior one to the last ganglion. For most other sensory fibres much shorter intracentral branches are indicated, though some of them extend for two ganglia in the anterior direction and for one posteriorly. All sensory fibres in the connectives run on the same side as they enter. 3. The segmental divisions of the external skeleton and of the nervous system do not coincide, the neural segment slants in a posterior dorsal direction with respect to the skeletal one. 4. For the majority of the interneurones which innervate more than two abdominal segments it has been proved that they synapse with primary sensory fibres in each of the ganglia that these enter. Depending on the segment stimulated with respect to the leading-off position, both ascending and descending impulses are obtained in such interneurones and collision of the impulses has been observed. Some consequences of this type of integration are discussed. 5. For interneurones responding to bilateral or heterolateral stimulation the course of the impulses proved to be of at least two types. In some, cutting the fibre prevents the arrival of impulses except those set up on the side of the cut from which the recording is made. In others, recording from either side of the cut fibre does not exclude any of the sensory fields to which the fibre normally responded. 6. At least one interneurone is present in which all primary sensory fibres from the different segments to whose activity it responds collect in one ganglion

A Bose-Einstein condensate in a random potential

An optical speckle potential is used to investigate the static and dynamic properties of a Bose-Einstein condensate in the presence of disorder. For strong disorder the condensate is localized in the deep wells of the potential. With smaller levels of disorder, stripes are observed in the expanded density profile and strong damping of dipole and quadrupole oscillations is seen. Uncorrelated frequency shifts of the two modes are measured for a weak disorder and are explained using a sum-rules approach and by the numerical solution of the Gross-Pitaevskii equation

Sediment management and the renewability of floodplain clay for structural ceramics

The Netherlands has vast resources of clay that are exploited for the fabrication of structural ceramic products such as bricks and roof tiles. Most clay is extracted from the so-called embanked floodplains along the rivers Rhine and Meuse, areas that are flooded during high-discharge conditions. Riverside clay extraction is-at least in theory-compensated by deposition. Based on a sediment balance (deposition versus extraction), we explore the extent to which clay can be regarded as a renewable resource, with potential for sustainable use. Beyond that, we discuss the implications for river and sediment management, especially for the large engineering works that are to be undertaken to increase the discharge capacities of the Rhine and Meuse. Extraction rates are based on production statistics for clay, as well as those for fired end-products. Deposition rates are estimated from published and unpublished geological data (clay volumes and thicknesses, datings, etc.) and from morphological modeling studies. Comparisons between extraction and deposition are made at three different time-space scales: (1) long term (post-1850)/large scale (all Dutch floodplains), (2) present/large scale, and (3) present/site scale. The year 1850 is relevant because it approximately marks the beginning of the current, fully engineered river systems, in which depositional processes are constrained by dikes and groynes. As the Industrial Revolution began in the same period, post-1850 sediments can be identified by their pollution with heavy metals. (1) We estimate the post-1850 clay volume in situ at about 0.20 km(3), and the total extracted volume in the same period at about 0.17 km(3). This puts the net long-term average deposition rate of clay at similar to 1.3 million m(3)/year and the corresponding extraction rate at similar to 1.1 million m(3)/year. (2) Current accumulation is approximately 0.4 million m(3)/year and expected to increase, and current extraction is about 0.7 million m(3)/year and expected to decrease. (3) Clay extraction creates a depression that has an increased sediment-trapping efficiency. This local effect is not considered explicitly in large-scale morphological modeling. Based on maximum observed sedimentation rates, we estimate that replenishment of a clay site takes in the order of 150 years. As clay extraction lowers some 0.5 km(2) of floodplain yearly, a surface area of approximately 75 km(2) would be required for sustainable clay extraction. This is about 1/6 of the total surface area of the embanked floodplains. On the long term, clay extraction from the embanked floodplain depositional environment has been sustainable. At strongly decreasing deposition rates, the ratio between extraction and replenishment seems to have shifted towards unsustainable. However, current sedimentation is estimated conservatively. The site-scale approach suggests that, even if extraction would currently exceed deposition, this could be resolved with sediment management, that is, with site restoration measures aimed at higher sediment-trapping efficiency. Our results have implications for river engineering, especially where substantial digging is involved (floodplain lowering, high-discharge bypass channels, obstacle removal). First, this inevitably affects the clay resources that we studied, while resource sterilization should be avoided. Secondly, the effect that any form of digging has on subsequent sedimentation-increased rates-relates to long-term river maintenance. We conclude that floodplain clay is a renewable resource, especially if managed accordingly. Beyond that, we established that clay extraction is a significant, lasting factor in floodplain evolution along the Rhine and Meuse Rivers. The interests of the extractive industry and river managers could be served jointly with sediment management plans that are based on sediment-budget analyse

Effect of optical disorder and single defects on the expansion of a Bose-Einstein condensate in a one-dimensional waveguide

We investigate the one-dimensional expansion of a Bose-Einstein condensate in an optical guide in the presence of a random potential created with optical speckles. With the speckle the expansion of the condensate is strongly inhibited. A detailed investigation has been carried out varying the experimental conditions and checking the expansion when a single optical defect is present. The experimental results are in good agreement with numerical calculations based on the Gross-Pitaevskii equation.Comment: 5 pages, 5 figure

The dangers of neglecting non-financial conflicts of interest in health and medicine

Non-financial interests, and the conflicts of interest that may result from them, are frequently overlooked in biomedicine. This is partly due to the complex and varied nature of these interests, and the limited evidence available regarding their prevalence and impact on biomedical research and clinical practice. We suggest that there are no meaningful conceptual distinctions, and few practical differences, between financial and non-financial conflicts of interest, and accordingly, that both require careful consideration. Further, a better understanding of the complexities of non-financial conflicts of interest, and their entanglement with financial conflicts of interest, may assist in the development of a more sophisticated approach to all forms of conflicts of interest.NHMRC Project Grant (APP1059732)

Status, respect and stigma: a qualitative study of non-financial interests in medicine

Conflicts of interest (COI) in health and medicine have been the source of considerable public and professional debate. Much of this debate has focused on financial, rather than non-financial COI, which is a significant lacuna because non-financial COI can be just as influential as financial COI. In an effort to explore the nature and effects of non-financial, as well as financial COI, we conducted semi-structured interviews with 11 Australian medical professionals regarding their experiences of, and attitudes towards, COI. We found that this group of medical professionals saw non-financial interests—most notably the pursuit of status and respect, and the avoidance of stigma—as potentially conflicting with other important interests (such as patient care).NHMRC Career Development Fellowship (APP1036539

Decay Rate Distributions of Disordered Slabs and Application to Random Lasers

We compute the distribution of the decay rates (also referred to as residues) of the eigenstates of a disordered slab from a numerical model. From the results of the numerical simulations, we are able to find simple analytical formulae that describe those results well. This is possible for samples both in the diffusive and in the localised regime. As example of a possible application, we investigate the lasing threshold of random lasers.Comment: 11 pages, 11 figure