Higgs Physics at LEP2

In this report we review the prospects for Higgs physics at LEP2. The theoretical aspects and the phenomenology of Higgs particles are discussed within the Standard Model (SM) and the Minimal Supersymmetric Standard Model (MSSM). The experimental search techniques are described and the discovery limits for Higgs bosons in the LEP2 energy range are summarized. In addition, opportunities of detecting Higgs particles in non-minimal extensions of the SM and the MSSM are investigated.Comment: 112 pages, latex file + figures (some bitmapped), to appear in Vol. 1, Report of the Workshop on Physics at LEP2, G. Altarelli, T. Sjostrand and F.Zwirner (eds), CERN 96-01. (Full postscript and uuencoded files, including full resolution figures are available at the www address http://surya11.cern.ch/surya_info/users/mcarena in finrep.ps, finrep.uu

An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

[(11)C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of signal are confounded by large interindividual variability in binding affinity, which displays a trimodal distribution compatible with a codominant genetic trait. Here, we tested directly for an underlying genetic mechanism to explain this. Binding affinity of PBR28 was measured in platelets isolated from 41 human subjects and tested for association with polymorphisms in TSPO and genes encoding other proteins in the TSPO complex. Complete agreement was observed between the TSPO Ala147Thr genotype and PBR28 binding affinity phenotype (P value=3.1 × 10(-13)). The TSPO Ala147Thr polymorphism predicts PBR28 binding affinity in human platelets. As all second-generation TSPO PET radioligands tested hitherto display a trimodal distribution in binding affinity analogous to PBR28, testing for this polymorphism may allow quantitative interpretation of TSPO PET studies with these radioligands