Whom should be saved? A proposed ethical framework for allocating scarce medical resources to COVID-19 patients using fuzzy logic

COVID-19 is a global pandemic that affected the everyday life activities of billions around the world. It is an unprecedented crisis that the modern world had never experienced before. It mainly affected the economic state and the health care system. The rapid and increasing number of infected patients overwhelmed the healthcare infrastructure, which causes high demand and, thus, shortage in the required staff members and medical resources. This shortage necessitates practical and ethical suggestions to guide clinicians and medical centers when allocating and reallocating scarce resources for and between COVID-19 patients. Many studies proposed a set of ethical principles that should be applied and implemented to address this problem. In this study, five different ethical principles based on the most commonly recommended principles and aligned with WHO guidelines and state-of-the-art practices proposed in the literature were identified, and recommendations for their applications were discussed. Furthermore, a recent study highlighted physicians' propensity to apply a combination of more than one ethical principle while prioritizing the medical resource allocation. Based on that, an ethical framework that is based on Fuzzy inference systems was proposed. The proposed framework's input is the identified ethical principles, and the output is a weighted value (per patient). This value can be used as a rank or a priority factor given to the patients based on their condition and other relevant information, like the severity of their disease status. The main idea of implementing fuzzy logic in the framework is to combine more than one principle when calculating the weighted value, hence mimicking what some physicians apply in practice. Moreover, the framework's rules are aligned with the identified ethical principles. This framework can help clinicians and guide them while making critical decisions to allocate/reallocate the limited medical resources during the current COVID-19 crisis and future similar pandemics

A framework for testing isotropy with the cosmic microwave background

We present a new framework for testing the isotropy of the Universe using cosmic microwave background data, building on the nested-sampling ANICOSMO code. Uniquely, we are able to constrain the scalar, vector and tensor degrees of freedom alike; previous studies only considered the vector mode (linked to vorticity). We employ Bianchi type VII$_h$ cosmologies to model the anisotropic Universe, from which other types may be obtained by taking suitable limits. In a separate development, we improve the statistical analysis by including the effect of Bianchi power in the high-$\ell$, as well as the low-$\ell$, likelihood. To understand the effect of all these changes, we apply our new techniques to WMAP data. We find no evidence for anisotropy, constraining shear in the vector mode to $(\sigma_V/H)_0 < 1.7 \times 10^{-10}$ (95% CL). For the first time, we place limits on the tensor mode; unlike other modes, the tensor shear can grow from a near-isotropic early Universe. The limit on this type of shear is $(\sigma_{T,\rm reg}/H)_0 < 2.4 \times 10^{-7}$ (95% CL).Comment: 11 pages, 6 figures, v3: minor modifications to match version accepted by MNRA

How isotropic is the Universe?

A fundamental assumption in the standard model of cosmology is that the Universe is isotropic on large scales. Breaking this assumption leads to a set of solutions to Einstein's field equations, known as Bianchi cosmologies, only a subset of which have ever been tested against data. For the first time, we consider all degrees of freedom in these solutions to conduct a general test of isotropy using cosmic microwave background temperature and polarization data from Planck. For the vector mode (associated with vorticity), we obtain a limit on the anisotropic expansion of $(\sigma_V/H)_0 < 4.7 \times 10^{-11}$ (95% CI), which is an order of magnitude tighter than previous Planck results that used CMB temperature only. We also place upper limits on other modes of anisotropic expansion, with the weakest limit arising from the regular tensor mode, $(\sigma_{T,\rm reg}/H)_0<1.0 \times 10^{-6}$ (95% CI). Including all degrees of freedom simultaneously for the first time, anisotropic expansion of the Universe is strongly disfavoured, with odds of 121,000:1 against.Comment: 6 pages, 1 figure, v2: replaced with version accepted by PR

Preparation of Immobilized-Polysiloxane Salicylaldehyde Propylimine and Its Application

A porous solid polysiloxane ligand system of the general formula P-(CH2) 3-C7H6NO,(where P represents [Si-O] n siloxane network) has been prepared by modification of the immobilized 3-aminopropylpolysiloxane, P-(CH2) 3NH2 with an exsess of salicylaldehyde. The new modified polysiloxane system exhibits good potential for uptake of Co 2+ and Cu 2+ metal ions. This ligand system gives more stable complexes with the divalent metal ions than its parent 3-aminopropylpolysiloxane precursor. Characterization was achieved using elemental analysis and FTIR spectroscopy

Polarized thermal emission by thin metal wires

We report new measurements of the linear polarization of thermal radiation emitted by incandescent thin tungsten wires, with thicknesses ranging from five to hundred microns. Our data show very good agreement with theoretical predictions, based on Drude-type fits to measured optical properties of tungsten.Comment: 12 pages, 4 encapsulated figures. This new version matches the one published in New. J. Phys.. Improved presentation, more references added, and one new figure include

Effect of COVID-19 quarantine on the sleep quality and the depressive symptom levels of university students in Jordan during the spring of 2020

Objectives: This study was designed to assess the effect of COVID-19 home quarantine and its lifestyle challenges on the sleep quality and mental health of a large sample of undergraduate University students in Jordan. It is the first study applied to the Jordanian population. The aim was to investigate how quarantine for several weeks changed the students' habits and affected their mental health. Methods: A cross-sectional study was conducted using a random representative sample of 6,157 undergraduate students (mean age 19.79 ± 1.67 years, males 28.7%) from the University of Jordan through voluntarily filling an online questionnaire. The Pittsburgh Sleep Quality Index (PSQI) and the Center for Epidemiologic Studies-Depression Scale (CES-D) were used to assess sleep quality and depressive symptoms, respectively. Results: The PSQI mean score for the study participants was 8.1 ± 3.6. The sleep quality of three-quarters of the participants was negatively affected by the extended quarantine. Nearly half of the participants reported poor sleep quality. The prevalence of poor sleep quality among participants was 76% (males: 71.5% and females: 77.8%). Similarly, the prevalence of the depressive symptoms was 71% (34% for moderate and 37% for high depressive symptoms), with females showing higher prevalence than males. The overall mean CES-D score for the group with low depressive symptoms is 9.3, for the moderate group is 19.8, while it is 34.3 for the high depressive symptoms group. More than half of the students (62.5%) reported that the quarantine had a negative effect on their mental health. Finally, females, smokers, and students with decreased income levels during the extended quarantine were the common exposures that are significantly associated with a higher risk of developing sleep disturbances and depressive symptoms. Conclusions: Mass and extended quarantine succeeded in controlling the spread of the COVID-19 virus; however, it comes with a high cost of potential psychological impacts. Most of the students reported that they suffer from sleeping disorders and had a degree of depressive symptoms. Officials should provide psychological support and clear guidance to help the general public to reduce these potential effects and overcome the quarantine period with minimum negative impacts

Synthesis and Characterization of Co(II), Ni(II), Cu(II) and Zn(II) Complexes with an ONO- and an NNO-Functionalized Ligand

A new ligand was synthesized from condensation of 2-aminophenol and 2-acetylbenzimidazole. This ligand (HAPAB, 6) was characterized based on elemental analysis, IR, 1H-NMR and 13C-NMR and MS spectral spectra. The complexes of the ligands, HAPAB (6) and 2-acetylfruan benzoylhydrazone (HAFBH, 3), with Co(II), Ni(II), Cu(II) and Zn(II), encoded a-d, were prepared by reaction of their methanolic acetate salts with the ligands in methanol in 1:2 metal to ligand mole ratio. These complexes, M(II)L2, 7a-d and 8a-d, were similarly characterized based on their physicochemical data by elemental analysis, IR, 1H-NMR and 13C-NMR, MS, molar conductance and electronic absorption spectra. The complexes consist of two ligands that give six coordinate bonding to each metal ion on a meridional plane through binding with the acetylfuran-O, the azomethine-N and the oxygen donor atom in the enol form of the hydrazone 3 and the 2-acetylbenzimidazole-N, the azomethine-N, and the phenoxo-O atoms of the imine 6 respectively. The ligands function as monobasic ONO- and NNO-trifunctional donor ligands where the deprotonated enolic form is preferred in the coordination producing distorted octahedral complexes. Key words: metal (II) complexes, Schiff bases, NNO-tridentate ligand, ONO-tridentate ligan

Cardioprotection of Immature Heart by Simultaneous Activation of PKA and Epac: A Role for the Mitochondrial Permeability Transition Pore

Metabolic and ionic changes during ischaemia predispose the heart to the damaging effects of reperfusion. Such changes and the resulting injury differ between immature and adult hearts. Therefore, cardioprotective strategies for adults must be tested in immature hearts. We have recently shown that the simultaneous activation of protein kinase A (PKA) and exchange protein activated by cAMP (Epac) confers marked cardioprotection in adult hearts. The aim of this study is to investigate the efficacy of this intervention in immature hearts and determine whether the mitochondrial permeability transition pore (MPTP) is involved. Isolated perfused Langendorff hearts from both adult and immature rats were exposed to global ischaemia and reperfusion injury (I/R) following control perfusion or perfusion after an equilibration period with activators of PKA and/or Epac. Functional outcome and reperfusion injury were measured and in parallel, mitochondria were isolated following 5 min of reperfusion to determine whether cardioprotective interventions involved changes in MPTP opening behaviour. Perfusion for 5 min preceding ischaemia of injury-matched adult and immature hearts with 5 µM 8-Br (8-Br-cAMP-AM), an activator of both PKA and Epac, led to significant reduction in post-reperfusion CK release and infarct size. Perfusion with this agent also led to a reduction in MPTP opening propensity in both adult and immature hearts. These data show that immature hearts are innately more resistant to I/R injury than adults, and that this is due to a reduced tendency of MPTP opening following reperfusion. Furthermore, simultaneous stimulation of PKA and Epac causes cardioprotection, which is additive to the innate resistance