72 research outputs found
1133 MRI-guided transurethral ultrasound ablation of prostate cancer: Preliminary outcomes of a phase I clinical trial
932 MR DIFFUSION IMAGING: A SPECIFIC IMAGING MODALITY FOR THE DETECTION OF PROSTATE CANCER
Kombination aus multiparametrischer MRT und ERSPC Risikokalkulator: Entwicklung eines Nomogramms zur Prädiktion signifikanter Prostatakarzinome
769 The value of MRI-targeted/TRUS-guided transperineal fusion biopsies for prostate cancer patients under active surveillance
Kombination klinischer und MR-Parameter zur Vorhersage der seitenspezifischen extraprostatischen Tumorausdehnung vor Radikaler Prostatektomie
Localised prostate cancer treated with MRI-guided transurethral ultrasound ablation: phase I trial results
A phase I study of temsirolimus (TEM) and bryostatin (BRYO) in patients with metastatic renal cell carcinoma (RCC)
Evolution of repeat prostate biopsy strategies incorporating transperineal and MRI-TRUS fusion techniques
Purpose: To test the hypothesis that MRI-TRUS fusion technique can increase the detection rate of prostate cancer (PC) in patients with previously negative biopsy. Methods: Patient records of men with persisting suspicion for PC after previous negative biopsy having undergone either extensive transrectal prostate biopsies (MD Anderson protocol; MDA), transperineal saturation (STP) or magnetic resonance imaging (MRI)/transrectal ultrasound (TRUS) fusion transperineal biopsies (MTTP) in three consecutive time intervals were reviewed retrospectively. The respective approach was the standard for the above indication at these episodes. In Cambridge, 70 patients underwent MDA biopsies, 75 STP underwent biopsies and 74 patients underwent MTTP biopsies. In total, 164 MTTP patients with the same indication from Heidelberg were analysed as reference standard. In total, 383 men were included into analysis. Low-grade PC was defined as Gleason score 7 (3 + 4) or lower. Results: Even though MTTP patients had significantly larger prostates, the overall cancer detection rate for PC was the highest in MTTP (24.2 % MDA, 41.3 % STP, 44.5 % MTTP, p = 0.027, Kruskal-Wallis test). The detection rate for clinically relevant high-grade PC was highest in MTTP; however, this did not reach statistical significance compared with MDA (23.5 % MDA, 12.9 % STP, 27.2 % MTTP, p = 0.25, Fischer's exact test). Comparing MTTP between Cambridge and Heidelberg, detection rates did not differ significantly (44.5 vs. 48 %, p = 0.58). There was a higher detection rate of high-grade cancer in Heidelberg. (36.3 vs. 27.2 %, p = 0.04). Conclusion: Patients whom are considered for repeat biopsies may benefit from undergoing MRI-targeted TRUS fusion technique due to higher cancer detection rate of significant PC. © 2014 Springer-Verlag Berlin Heidelberg
Can high-spatial resolution T2-weighted endorectal MRI rule out clinically significant prostate cancer?
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