Probabilistic design of advanced composite structure

Advanced composite technology offers potentials for sizable improvements in many areas: weight savings, maintainability, durability, and reliability. However, there are a number of inhibitors to these improvements. One of the biggest inhibitors is the imposition of traditional metallic approaches to design of composite structure. This is especially detrimental in composites because new materials technology demands new design approaches. Of particular importance are the decisions made regarding structural criteria. Significant changes cannot be implemented without careful consideration and exploration. This new approach is to implement changes on a controlled, verifiable basis. Probabilistic design is the methodology and the process to accomplish this. Its foundation is to base design criteria and objectives on reliability targets instead of arbitrary factors carried over from metallic structural history. The background is discussed of probabilistic design and the results are presented of a side-by-side comparison to generic aircraft structure designed the 'old' way and the 'new'. Activities are also defined that need to be undertaken to evolve available approaches to probabilistic design followed by summary and recommendations

Ovarian Damage During Chemotherapy in Autoimmune Diseases: Broad Health Implications beyond Fertility

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94402/1/Marder_2012_Ovarian_damage_chemotherapy_autoimmune.pdf165

Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients

The incidence of oral squamous cell carcinoma remains high. Oral and oro-pharyngeal carcinomas are the sixth most common cancer in the world. Several clinicopathological parameters have been implicated in prognosis, recurrence and survival, following oral squamous cell carcinoma. In this retrospective analysis, clinicopathological parameters of 115 T1/T2 OSCC were studied and compared to recurrence and death from tumour-related causes. The study protocol was approved by the Joint UCL/UCLH committees of the ethics for human research. The patients' data was entered onto proformas, which were validated and checked by interval sampling. The fields included a range of clinical, operative and histopathological variables related to the status of the surgical margins. Data collection also included recurrence, cause of death, date of death and last clinic review. Causes of death were collated in 4 categories (1) death from locoregional spread, (2) death from distant metastasis, (3) death from bronchopulmonary pneumonia, and (4) death from any non-tumour event that lead to cardiorespiratory failure. The patients' population comprised 65 males and 50 females. Their mean age at the 1 diagnosis of OSCC was 61.7 years. Two-thirds of the patients were Caucasians. Primary sites were mainly identified in the tongue, floor of mouth (FOM), buccal mucosa and alveolus. Most of the identified OSCCs were low-risk (T1N0 and T2N0). All patients underwent primary resection neck dissection and reconstruction when necessary. Twenty-two patients needed adjuvant radiotherapy. Pathological analysis revealed that half of the patients had moderately differentiated OSCC. pTNM slightly differed from the cTNM and showed that 70.4% of the patients had low-risk OSCC. Tumour clearance was ultimately achieved in 107 patients. Follow-up resulted in a 3-year survival of 74.8% and a 5-year survival of 72.2%. Recurrence was identified in 23 males and 20 females. The mean age of 1 diagnosis of the recurrence group was 59.53 years. Most common oral sites included the lateral border of tongue and floor of mouth. Recurrence was associated with clinical N-stage disease. The surgical margins in this group was evaluated and found that 17 had non-cohesive invasion, 30 had dysplasia at margin, 21 had vascular invasion, 9 had nerve invasion and 3 had bony invasion. Severe dysplasia was present in 37 patients. Tumour clearance was achieved in only 8 patients. The mean depth of tumour invasion in the recurrence group was 7.6 mm. An interesting finding was that 5/11 patients who died of distant metastasis had their primary disease in the tongue. Nodal disease comparison showed that 8/10 patients who died of locoregional metastasis and 8/11 patients who died from distant metastasis had clinical nodal involvement. Comparing this to pathological nodal disease (pTNM) showed that 10/10 patients and 10/11 patients who died from locoregional and distant metastasis, respectively, had nodal disease. All patients who died from locoregional and distant metastasis were shown to have recurrence after the primary tumour resection. Squamous cell carcinoma of the oral cavity has a poor overall prognosis with a high tendency to recur at the primary site and extend to involve the cervical lymph nodes. Several clinicopathological parameters can be employed to assess outcome, recurrence and overall survival. © 2010 Jerjes et al; licensee BioMed Central Ltd

A moderate switch from high to low-glycaemic index foods for 3 weeks improves the metabolic control of type 1 (insulin-dependent) diabetic patients

International audienc

DIFFUSION ELASTIQUE D'ELECTRONS SUR L'HELIUM 3 DANS LA REGION 8,8 fm-2 ≤ q2 ≤ 15,6 fm-2

Les sections efficaces de diffusion d'électrons sur He3 ont été mesurées pour 4 valeurs du carré du transfert d'impulsion : 8,8 11,8 13,7 et 15,6 fm-2. On en a extrait les facteurs de forme longitudinal et transverse. Le facteur de forme transverse ne présente pas de minimum.Electron scattering cross sections have been measured for 4 values of squared momentum transfer : 8.8 11.8 13.7 and 15.6 fm-2. Longitudinal and transverse form factors were extracted. There is no evidence of a minimum in the transverse form factor

A moderate switch from high to low-glycaemic index foods for 3 weeks improves the metabolic control of type 1 (insulin-dependent) diabetic patients

International audienc

Histocompatibility Leukocyte Antigen-A29-Associated Retinal Vasculitis without Choroidal Lesions: A Report of 4 Cases

This study describes a cohort of patients presenting with histocompatibility leukocyte antigen (HLA)-A29-associated retinal vasculitis without choroidal lesions that may share clinical features with birdshot retinochoroiditis. The methods include a retrospective chart review of patients presenting with HLA-A29-associated retinal vasculitis without choroidal lesions. The data on the patients were entered retrospectively into a new database and analyzed. Four patients who had HLA-A29-associated retinal vasculitis without choroidal lesions were identified. The median age at presentation was 40 years (range: 14–71); 75% were female. At presentation, all four patients had a visual acuity of 20/50 or better in both eyes. All the eyes had mild vitritis, three eyes (37.5%) had cystoid macular edema, and two eyes (25%) had optic disc edema. All the patients required treatment with systemic steroids and immunosuppressive therapy. HLA-A29-associated retinal vasculitis without choroidal lesions appears to share many clinical features with birdshot chorioretinitis, including the need for systemic immunosuppressive therapy. Whether this entity represents an early form of birdshot retinochoroiditis or a more localized variant of the disease is a topic for additional studies