Minimising investment risks through optimising public-private partnership: the case of the Kaliningrad region

This study undertakes a contextual analysis of economic and legal risks associated with investment in the Kaliningrad region. The authors emphasise the importance of public-private partnership (PPP) in minimising such risks in order to enhance the region's attractiveness and to solve development problems. PPP has never been studied as a means to minimise regional investment risks in current conditions. This accounts for the scientific novelty of examining investment risks minimisation through proving the essentiality of developing PPP mechanisms on a unique Russian territory - the Kaliningrad region. The article analyses current investment risks, conditions, barriers, and avenues to enhance the investment climate in the Kaliningrad region. The authors utilise data on current investment in the region and consider the principles of the region's investment policy. The study stresses the need to develop the regional economy's "points of growth" within PPP schemes. It is proposed that the region and its municipalities should participate in partner projects in a manner that, firstly, is transparent to national and international investors and concordant with best practices and, secondly, enables the executive authorities and businesses to collaborate in developing the most efficient legal framework for partnership. The article identifies the role of PPP in solving the problem of regional development and gives recommendations on overcoming barriers and implementing PPP projects in the region

Kinetics of Neutralizing Antibodies of COVID-19 Patients Tested Using Clinical D614G, B.1.1.7, and B 1.351 Isolates in Microneutralization Assays

Increasing evidence suggests that some newly emerged SARS-CoV-2 variants of concern (VoCs) resist neutralization by antibodies elicited by the early-pandemic wild-type virus. We applied neutralization tests to paired recoveree sera (n = 38) using clinical isolates representing the first wave (D614G), VoC1, and VoC2 lineages (B.1.1.7 and B 1.351). Neutralizing antibodies inhibited contemporary and VoC1 lineages, whereas inhibition of VoC2 was reduced 8-fold, with 50% of sera failing to show neutralization. These results provide evidence for the increased potential of VoC2 to reinfect previously SARS-CoV-infected individuals. The kinetics of NAbs in different patients showed similar decline against all variants, with generally low initial anti-B.1.351 responses becoming undetectable, but with anti-B.1.1.7 NAbs remaining detectable (>20) for months after acute infection

Kinetics of Neutralizing Antibodies of COVID-19 Patients Tested Using Clinical D614G, B.1.1.7, and B 1.351 Isolates in Microneutralization Assays

Increasing evidence suggests that some newly emerged SARS-CoV-2 variants of concern (VoCs) resist neutralization by antibodies elicited by the early-pandemic wild-type virus. We applied neutralization tests to paired recoveree sera (n = 38) using clinical isolates representing the first wave (D614G), VoC1, and VoC2 lineages (B.1.1.7 and B 1.351). Neutralizing antibodies inhibited contemporary and VoC1 lineages, whereas inhibition of VoC2 was reduced 8-fold, with 50% of sera failing to show neutralization. These results provide evidence for the increased potential of VoC2 to reinfect previously SARS-CoV-infected individuals. The kinetics of NAbs in different patients showed similar decline against all variants, with generally low initial anti-B.1.351 responses becoming undetectable, but with anti-B.1.1.7 NAbs remaining detectable (>20) for months after acute infection

Kinetics of Neutralizing Antibodies of COVID-19 Patients Tested Using Clinical D614G, B.1.1.7, and B 1.351 Isolates in Microneutralization Assays

Increasing evidence suggests that some newly emerged SARS-CoV-2 variants of concern (VoCs) resist neutralization by antibodies elicited by the early-pandemic wild-type virus. We applied neutralization tests to paired recoveree sera (n = 38) using clinical isolates representing the first wave (D614G), VoC1, and VoC2 lineages (B.1.1.7 and B 1.351). Neutralizing antibodies inhibited contemporary and VoC1 lineages, whereas inhibition of VoC2 was reduced 8-fold, with 50% of sera failing to show neutralization. These results provide evidence for the increased potential of VoC2 to reinfect previously SARS-CoV-infected individuals. The kinetics of NAbs in different patients showed similar decline against all variants, with generally low initial anti-B.1.351 responses becoming undetectable, but with anti-B.1.1.7 NAbs remaining detectable (>20) for months after acute infection

Global sustainable city-regions: Stockholm, Berlin, Kolkata, Abu Dhabi/Masdar, Bengaluru, Malawi, Belfast, Hong Kong, Seoul, Helsinki, & Scotland

This policy report, entitled ‘Global Sustainable City-Regions,’ covers the work developed by the lecturer, Dr Igor Calzada, MBA, FeRSA, as the editor of the publica- tion and students of the second edition of the Master course MSc in Leadership for Global Sustainable Cities from September to December 2016. Specifically, this policy report follows a two-sequential-module structure: • The first module, entitled ‘Global Cities: Sustainability and Society,’ consists of six methodological units. • Thereafter, the second module, entitled ‘Public Policy, Governance and Strategic Change in Cities,’ consists of five methodological units. The policy report focuses on three urban global issues in a comparative basis. The MSc was developed in a team-based dynamic by applying qualitative action research methodologies to understand and interpret each case and to benchmark and contrast with other cases that addressed the same global urban issue. The cases were selected jointly by the lecturer and the students in a dynamic process in order to achieve a suitable selection of cases that would allow them to: • arrange groups around one specific global urban issue, • compare cases around the same specific urban issue, and • produce a full case study by applying the two-sequential-module methodology. • Transformative Smart Cities: In recent years, the smart city paradigm has gained traction in urban policy and governance. Underlying the smart city discourse is the techno-utopian belief that the use of information and communication technologies (ICTs) is imperative to confront the challenges of urbanization and sustainable development. Although, little has been researched about the differences between this paradigm and its consequences in the Global South and in the Global North. In addition to this, since the smart city as a buzzword has conquered policy agendas worldwide, a transformational push is occurring in some innovative cities and regions worldwide. This urban issue called ‘Transformative Smart Cities’ is explained comparatively through five cases as follows: Stockholm, Kolkata, Masdar, Bengaluru, and Seoul. • Changing Social Innovation: Urban issues are usually complex and interconnected phenomena. Poverty, political conflicts, environmental awareness, mobility and transport mechanisms, geopolitical path-dependence, ethno-political unrest, digital connectivity and self-determination could be researched from the social innovation changing perspective. The capacity to think across and between as well as within the thematic factors is crucial. Likewise, a clear understanding of the way in which different disciplines can contribute to a step change in delivery against these changing challenges is therefore required. Ultimately, an awareness of the underlying factors and contexts (including social, political, economic, cultural, technological and historial), interdependencies, synergies, tensions and trade-offs that promote, obstruct or even reverse delivery against social innovation, both individually and collectively are key to understand changing dynamics in city-regions. This urban issue called ‘Changing Social Innovation’ is explained comparatively through six cases as follows: Berlin, Belfast, Malawi, Hong Kong, Helsinki, and Glasgow

Global sustainable city-regions: Stockholm, Berlin, Kolkata, Abu Dhabi/Masdar, Bengaluru, Malawi, Belfast, Hong Kong, Seoul, Helsinki, & Scotland

This policy report, entitled ‘Global Sustainable City-Regions,’ covers the work developed by the lecturer, Dr Igor Calzada, MBA, FeRSA, as the editor of the publica- tion and students of the second edition of the Master course MSc in Leadership for Global Sustainable Cities from September to December 2016. Specifically, this policy report follows a two-sequential-module structure: • The first module, entitled ‘Global Cities: Sustainability and Society,’ consists of six methodological units. • Thereafter, the second module, entitled ‘Public Policy, Governance and Strategic Change in Cities,’ consists of five methodological units. The policy report focuses on three urban global issues in a comparative basis. The MSc was developed in a team-based dynamic by applying qualitative action research methodologies to understand and interpret each case and to benchmark and contrast with other cases that addressed the same global urban issue. The cases were selected jointly by the lecturer and the students in a dynamic process in order to achieve a suitable selection of cases that would allow them to: • arrange groups around one specific global urban issue, • compare cases around the same specific urban issue, and • produce a full case study by applying the two-sequential-module methodology. • Transformative Smart Cities: In recent years, the smart city paradigm has gained traction in urban policy and governance. Underlying the smart city discourse is the techno-utopian belief that the use of information and communication technologies (ICTs) is imperative to confront the challenges of urbanization and sustainable development. Although, little has been researched about the differences between this paradigm and its consequences in the Global South and in the Global North. In addition to this, since the smart city as a buzzword has conquered policy agendas worldwide, a transformational push is occurring in some innovative cities and regions worldwide. This urban issue called ‘Transformative Smart Cities’ is explained comparatively through five cases as follows: Stockholm, Kolkata, Masdar, Bengaluru, and Seoul. • Changing Social Innovation: Urban issues are usually complex and interconnected phenomena. Poverty, political conflicts, environmental awareness, mobility and transport mechanisms, geopolitical path-dependence, ethno-political unrest, digital connectivity and self-determination could be researched from the social innovation changing perspective. The capacity to think across and between as well as within the thematic factors is crucial. Likewise, a clear understanding of the way in which different disciplines can contribute to a step change in delivery against these changing challenges is therefore required. Ultimately, an awareness of the underlying factors and contexts (including social, political, economic, cultural, technological and historial), interdependencies, synergies, tensions and trade-offs that promote, obstruct or even reverse delivery against social innovation, both individually and collectively are key to understand changing dynamics in city-regions. This urban issue called ‘Changing Social Innovation’ is explained comparatively through six cases as follows: Berlin, Belfast, Malawi, Hong Kong, Helsinki, and Glasgow

Scopolamine Administration Modulates Muscarinic, Nicotinic and NMDA Receptor Systems

Studies on the effect of scopolamine on memory are abundant but so far only regulation of the muscarinic receptor (M1) has been reported. We hypothesized that levels of other cholinergic brain receptors as the nicotinic receptors and the N-methyl-D-aspartate (NMDA) receptor, known to be involved in memory formation, would be modified by scopolamine administration