A deworming field trial with ivermectin (MSD) in reindeer

This paper is to be regarded as a follow-up under field conditions of Nordkvist et al. (1983) as far as ivermectin is concerned. 54 reindeer calves (29 males + 25 females), as far as possible of normal size, were selected November 15th, 1982 from a reindeer herd belonging to Maskaure sameby, Arvidsjaur. The calves were individually branded, by means of ear tags and weighed. 29 calves (15 males + 14 females) were treated with ivermectin (Ivomec 1% MSD) at a dose rate of 1 ml per calf (roughly corresponding to 200 meg ivermectin per kg body weight), subcutaneous injection. Remaining 25 calves (14 males + 11 females) served as untreated controls. The entire group of calves was then returned to the herd for free grazing during winter. During the winter 3 treated calves were found dead, all three of them had been suffering from keratoconjunctivitis. If any of the control animals had succumbed during the same time is not known. On April 21st, 1983 (approx. 150 days post treatment) 44 calves (24 treated + 20 controls) were weighed. 5 treated and 5 controls were randomly selected for slaughter. Carcasses and organs were thoroughly examined from a parasitological and, as far as lungs were concerned, pathological point of view. The efficacy of the treatment was 100(M> or nearly 100% against Oedemagena tarandi, Cephenemyia trompe, Dictyocaulus viviparus, Elaphostrongylus rangiferi, and nematode eggs in faeces. The efficacy against gastrointestinal nematodes was, probably due to date of treatment, somewhat difficult to judge (Tab 1). A statistical analysis of the weight changes, relative to initial weights, (Tab. 2) supports the statements — that all animals had lost weight — that treated males had lost significantly less of their body weights than control males — That weight change of treated females did not differ significantly from that of control females — that the average weight loss of the entire treated group was significantly less than that of the control group.Ett fältavmaskningsförsök med ivermectin (MSD) på renar.Abstract in Swedish / Sammanfattning: 54 renkalvar (29 m + 25 f) såvitt mojligt av normal storlek, utvaldes den 25 november 1982 ur en renhjord tillhorig Maskaure sameby, Arjeplog. Kalvarna mdividmårktes med oronknappar och vågdes. Av dessa behandlades 29 kalvar (15 0*0" + 14 $9) med ivermectin (Ivomec, 1% MSD), 1 ml per kalv, subkutan injektion. Resterande 25 kalvar fungerade som obehandlade kontrolldjur. Den 21 april 1983 (efter 147 dagar) vågdes ånyo 44 (24 behandlade + 20 kontroller) av de ursprungliga djuren. 5 renar i vardera gruppen slaktades och kropp och organ undersoktes parasitologiskt. Effekten av behandlingen var 100% eller nåstintill mot Oedemagena tarandi, Cephenemyia trompe, Dictyocaulus viviparus, Elaphostrongulus rangiferi samt vad gällde forekomsten av nematodågg i tracken. Effekten på mag-tarmnematoder var, med hånsyn till behandlingstidpunkten, svårbedomd. Effekten på trichostrongylida lopmagsmaskar var också svårbedomd och diskuteras i texten. Den relativa forandringen av renarnas kroppsvikt, dvs forandringen i forhållande till ursprungsvikten, har beråknats och statistiskt bearbetats. Det kunde då konstateras — att samtliga renar hade forlorat i vikt — att den genomsnittliga viktforlusten hos de behandlade hankalvarna var signifikant lågre ån hos de obehandlade hankalvarna — att den genomsnittliga viktforlusten hos de behandlade honkalvarna ime skiljde sig statistiskt från viktforlusten hos de obehandlade honkalvarna — att den genomsnittliga viktforlusten i hela den behandlade gruppen var signifikant lagre ån i den obehandlade gruppen.Kenttätutkimus porojen matokuurista Ivermectinillä (MSD).Abstract in Finnish / Yhteenveto: Arjeplogissa Maskauren lappalaiskylåån kuuluvasta porotokasta valittiin 25. marraskuuta 1982 54 porovasaa (29 m + 25 f) mikåli mahdollista normaalikokoa. Vasat yksilomerkittiin korvanastoilla ja punnittiin. Nåistå kåsiteltiin 29 vasaa (15 m + 14 f) ivermectinillå (Ivomec, 1 % MSD), 1 ml vasaa kohden, ruiskutcttuna nahan alle. Loput 25 vasaa toimivat kåsittelemåttominå tarkkailuelåiminå. 21 huhtikuuta 1983 (147 påivån jålkeen) punnittiin uudelleen 44 (24 kåsiteltyå + 20 tarkkailuelåintå) alkuperåisistå elåimistå. Joka ryhmåstå teurastettiin 5 poroa ja ruho ja sisåelimet tutkittiin parasitoloogisesti. Kåsittelyn vaikutus oli 100% tai låhes tåydellinen seuraavia kohtaan: Oedemagena tarandi, Cephenemyia trompe, Dictyocaulus viviparus, Elapohostrongylus rangiferi sekå myoskin mitå tulee matojen munien esiintymiseen sonnassa. Vaikutus maha - ja suolistomatoihin oli, kåsittelyn ajankohdan huomioonottaen, vaikeasti ratkaistavissa. Vaikutus juoksutusmahoihin (trichostrongylida) oli myos vaikeasti ratkaistavissa ja siitå keskustellaan tekstisså. Porojen ruhojen painon suhteellinen muutos, t.s. muutos suhteessa alkuperåispainoon on arvioitu ja tilastollisesti kåsitelty. Voitiin silloin todeta — ettå kaikki porot olivat kevcntyneet painossaan, — ettå kåsiteltyjen urosvasojen keskimååråinen painonvåhennys oli merkitsevåsti alhaisempi kuin kåsittelemåttomien urosvasojen, — ettå kåsiteltyjen naarasvasoien keskimååråinen painonvåhennys ei eronnut tilastollistesti kåsittelemåttomien naarasvasojen painonvåhennyksestå, — ettå koko kåsitellyn ryhmån keskimååråinen painonvåhennys oli merkitsevåsti alhaisempi kuin kåsittelemåttomåsså ryhmåsså

Eugen Ehrlich als Rechtslehrer

Евгений Эрлих один из основателей свободного движения права, социологии права. Он создал основы для расширения научных связей между правом, обществом и методами исследования “живого права”. Основные научные работы: “Вклад в теорию юридических источников”, “Безмолвное волеизлияние”, “Свободное правонахождение и свободная юриспруденция”, “Юридическая логика”. Как преподаватель права Е. Эрлих работал на Буковине до начала Первой мировой войны, позже, он преподавал в Швейцарии и имел большой авторитет, как у студентов, так и у своих коллег.Eugen Ehrlich is the founder of the movement of free law and the sociology of law. He laid the foundation for broader scientific relations between law, society and methods of research into the living law. His major works: “Contribution to the Theory of Sources of Law”, “The Silent Will Expression”, “The Free Law Finding and Free Jurisprudence”, “The Juridical Logic”. As teacher of law, prior to the World War I Eugen Ehrlich worked in the Bukovyna and later taught in the Swiss, and had a high reputation among students and his colleagues

Eugen Ehrlichs Seminar für Lebendes Recht: Eine Einrichtung für die Weiterbildung von Rechtspraktikern

Если правосудие отдает должное необходимости присутствия современности, организационно нужно заботиться о том, чтоб действующие на практике юристы могли повышать квалификацию. В работе “Безмолвное волеизъявление” Эрлих упоминает, что социологический метод должен дополняться непосредственным наблюдением жизни. В современных условиях высшей школы, семинар по живому праву Эрлиха помогает выполнить задание переподготовки юристов-практиков, а также остается образцом и стимулом повышения квалификации и образованости юристов.If the justice system wants respectively treat the present, it is organisationally needed to ensure that practisizing lawyers could undergo futher professional training. In his work “Die stillschweigende Willenserklärung” Ehrlich underscored that the sociological method should be aided by the direct observation of the life. Within the present system of the higher education of lawyers a seminar on living law may be instrumental in retraing of practicing lawyers, could remain a model and stimulus for further professional development and education of lawyers

Der Pluralismus des Rechts im Zeitalter der Globasierung. Zum Rechtsbegriff in der Rechtssoziologie

Социология права избрала путь исследования особенностей живого права. Особое внимание обращается на внутренний плюрализм права, когда недопустимым есть плюрализм понятий права в внутреннем праве суверенного государства. Только государственная сфера – это точка соприкосновения и существования живого права. О плюрализме понятий права может говорить только как о политическом идеале, но не как о критерии права. Транснациональный плюрализм права характерен тем, что суверенитет не может раскрываться путем передачи суверенных прав, потому что в противном случае национальное государство потеряет свое качество носителя правопорядка.The sociology of law chose the way of studying the features of the living law. Special attention is paid to the inner pluralism of law where the pluralism of law as a part of the internal state law is deemed unacceptable. Only the state sphere is considered as a crossing point and living place of the living law. One can talk about the pluralism of law only in terms of political ideal but not as of a criterion of law. The transnational pluralism of law is characterized by that the sovereignty may not be exercised by the transfer of sovereign rights because in the opposite case a national state will lose its quality of the carrier of the legal order

Pathology of acute and subchronic nitrate poisening in reindeer (Rangifer tarandus L)

The pathology of nitrate poisoning by forest fertilizers to reindeer was studied. The post mortem picture differed with substance, dose and time of exposure. Animals that died from acute ammonium nitrate intoxication had lesions similar to those found in acute ammonium and nitrate poisoning in sheep and cattle, without developing methaemoglobinemia. The animal that died from acute sodium nitrate poisoning probably died from acute collapse of the blood pressure without developing methaemoglobinemia and without any significant post mortem lesions. Animals dead of subchronic sodium nitrate poisoning all developed methaemoglobinemia. Animals dead within 24 hours only revealed subserous haemorrhages in the pleura and haemorrhages in musculus longissimus costarum and musculus longissimus dorsi. Similar pleural and muscular haemorrhages were also found in animals that died 60 - 200 hours after exposure but in these animals were also found what is considered common lesions in connection with nitrate/nitrite posoning; i.e. discolorated and poorly clotted blood, cardiac hamorrhages etc. The constant finding of these pleural and muscular haemorrhages may indicate almost pathognomonic lesions, in reindeer, in connection with nitrate poisoning of subchronic and chronic nature. The two animals that died from voluntarily drinking ammonium-nitrate dissolved in water developed lesions indicative of a combined effect of ammonium and nitrate poisoning. Patologin vid akut och subkronisk nitratforgiftning hos ren (Rangifer tarandus L) Abstract in Swedish / Sammanfattning: Patologin vid nitratforgiftning, orsakad av skogsgodselmedel, hos ren har undersokts. Obduktionsbilden varierade med godselmedel, dosering och exponeringstid. Djuren som dog av akut ammoniumnitratforgiftning uppvisade likartade forandringar som ses vid akut ammonium-och nitratforgiftning hos får och notkreatur. Inget av djuren utvecklade methaemoglobinemi. Det djur som dog av akut natriumnitratforgiftning dog troligen av en akut blodtryckskollaps utan att utveckla methaemoglobinemi. Djur vilka dog av subkronisk natriumnitratforgiftning utvecklade alla methaemoglobinemi. Djuren som dog inom 24 timmar uppvisade enbart subserosa Modningar i pleura och blodningar i musculus longissimus costarum och musculus longissimus dorsi. Liknande blodningar i pleura och samma muskler sigs också hos djur som dog 60 - 200 timmar efter exposition. Hos dessa djur sågs emellertid också forhindringar som anses vanliga i samband med nitrat/nitritforgiftning såsom, missfårgat dåligt koagulerat blod, blodningar i hjårtat etc. Det genomgående fyndet av dessa blodningar i pleura och dorsala rygg- brostmuskler, hos ren, i samband med nitratforgiftning av subkronisk eller kronisk karaktår, ar en indikation på synbarligen patognomoniska forandringar. De två djur som dog efter att frivilligt ha druckit ammoniumnitrat lost i vatten utvecklade forandringar tydande pi en kombinerad effekt av ammonium- och nitratforgiftning. Poron (Rangifer tarandus L) åkillisen subkroonisen nitraattimyrkytyksen patologia. Abstract in Finnsih / Yhteenveto: Tutkittiin metsånlannoitteiden aiheuttaman nitraattimyrkytyksen patologiaa poroissa. Ruumiinavau-skuva vaihteli lannoitteesta, annostuksesta ja altistamisajasta riippuen. Akilliseen ammoniumnitraattimyrkytykseen kuolleissa elaimisså muutokset olivat samankaltaisia kuin lampaiden ja nautojen akillisessa ammonium ja nitraattimyrkytyksessa. Yhteenkaån elåimeen ei kehittynyt methemoglobinemiaa. Eras akilliseen natriumnitraattimyrkytykseen kuollut elain menehtyi luultavasti akilliseen verenpainekollapsiin ilman methemoglobinemian kehittymista. Kaikkiin subkrooniseen natriumnitraattimyrkytykseen kuolleisiin elåimiin kehittyi methemoglobinemia. Kahden-kymmenenneljån tunnin sisalla kuolleissa elaimisså ilmeni ainoastaan rintakalvonalaisia verenvuotoja sekå verenvuotoja Musculus longissimus costarumissa ja M. longissimus dorsissa. Samankaltaisia verenvuotoja rintakalvossa ja samoissa lihaksissa nåhtiin myos niisså elaimisså, jotka kuolivat 60 - 200 tuntia altistamisen jålkeen. Nåisså elaimisså havaittiin kuitenkin myos nitraatti/nitriittimyrkytyksen yhteydesså tavallisina pidettåviå muutoksia kuten våriltåån muuttunut ja huonosti hyytynyt veri, verenvuotoja sydåmesså jne. Porojen subkroonisessa tai kroonisess nitraattimyrkytyksesså såånnollisenå loydoksenå tavatut verenvuodot rintakalvossa ja ylemmåsså selkårintalihaksistossa viittaavat siihen, ettå muutokset ilmeisesti ovat tålle myrkytykselle ominaisia. Niihin kahteen elaimeen, jotka kuolivat juotuaan vapaaehtoisesti veteen liuotettua ammoniumnitraattia, kehittyi ammonium - ja nitraattimyrkytyksen yhteisvaikutukseen viittaavia muutoksia

A suspected virus infection of the oral mucosa in Swedish reindeer (Rangifer tarandus L)

During the winter 1980 reindeer herds in the Tornedalen area, along the Finnish border, were hit by grazing difficulties. Thus minor parts of the reindeer her*ds in this area were given supplementary feed in pens. Some of the supplementary fed animals were taken ill and some deaths occurred. According to the owners sick animals showed loss of appetite and signs of fever. A total of 8 carcasses were necropsied at The National Veterinary Institute. In 5 of these cases oral lesions were observed. The histological investigation of the oral mucosa revealed intracytoplasmic inclusion bodies, inter- and intracellular oedema and vesicle formation. An electron-microscopical study of 2 of the cases confirmed the histological findings. At the bacteriological investigations Coli, ß-haemolyzing streptococci, Conrynebacterium pyogenes and Fusobacterium necrophorum could be indentified. The found bacteria were all considered secondary invaders. Serological samples from four affected reindeer flocks were tested for antibodies against BVD-, P13 and IBR-virus as well as Chlamydia. A few samples showed low positive titres for agents tested but for BVDV. The result of the investigation indicates that a still unidentified virus could be the primary cause of this enzootically appearing disease of the oral mucosa in reindeer.Misstanke om virusinfektion i munnslemhinnan på svensk ren.Abstract in Swedish / Sammanfattning: Under vintern 1980 drabbades renhjordar i Tornedalsområdet av betessvårigheter. Av denna anledning fördes mindre flockar, ur hjordarna, till inhägnader och tillskottsutfodrades. En del av de tillskottsutfodrade djuren insjuknade och dödsfall inträffade. Enligt djurägarna förlorade de sjuka djuren aptiten och uppvisade tecken på feber. Av de döda renarna erhölls åtta fôr obduktion vid Statens Veterinärmedicinska anstalt. Hos fem av de obducerade renarna forelåg skador i munhålan. Vid histologisk undersokning av munslemhinnan påvisades intracytoplasmatiska inklusionskroppar, inter- och intracellulärt ödem och vesikelbildningar. Elektronmikroskopisk undersokning av två av fallen konfirmerade de histologiska undersökningarna. Vid de bakteriologiska undersökningarna påvisades våxt av kolibakterier, ß-hemolyserande streptokocker, Corynebacterium pyogenes och Fusobacterium necrophorum. I samtliga fall betraktades dessa som sekundårinfektio-ner. Serologiska undersökningar företogs, i fyra flockar dår dödsfall förekommit, avseende forekomst av antikroppar emot BVD-virus, Pi3 och IBR-virus samt Chlamydia. Ett mindre antal prover uppvisade positiva titrar fôr de undersökta agens utom vad avser BVD. Resultaten av undersökningarna indikerar att ett annu ej identifierat virus kan vara primärorsak till de enzootiskt upptrådande utbrotten av sjukliga förändringar i munhålen hos ren

Ultimate pH values and bacteriological condition of meat and stress metabolites in blood of transported reindeer bulls

Twenty-three reindeer bulls, aged 2-3 years, fed during two winter months at the Vuolda reindeer research station in Arjeplog, Sweden, were used in the study. The first group of eight reindeer was moved from their feeding corral to a selection corral, captured by lasso and stunned with a captive bolt outside the selection corral. The second group of seven reindeer was moved to the selection corral, captured by lasso and restrained, after which they were loaded onto a lorry- and transported for 1 hour and then slaughtered. The third group of eight reindeer was moved to the selection corral and herded directly onto the lorry, without any manual handling. They were transported for 5 h and then slaughtered. In both transport groups, four reindeer were fitted with pre-programmed automatic blood sampling equipment (ABSE). ABSE sampled blood at predetermined times via a jugular vein catheter. Ultimate pH-values in three muscles (Mm. longissimus, triceps brachii and biceps femoris) were significantly lower in the group carefully handled and transported for 5 h compared with the other two groups. The physiological mechanisms behind these results are discussed. Samples from M. semimembranosus were collected at slaughter and after 2, 6 and 10 days of refrigerated storage (+4 °C). The samples were analysed for total counts of aerobic bacteria (pour-plated in Tryptone Glucose Extract Agar, Difco, incubated at 20 °C and 30 °C, respectively for 72 h), coliform bacteria 37 °C (pour-plated in Violet Red Bile Agar, Oxoid, incubated at 37 °C for 24 h), Enterococci (surface-plated onto Slantez and Bartley Agar, Oxoid, incubated at 44 °C for 48 h) and Bacillus cereus (surface-plated onto Blood Agar Plates (Blood Agar Base, Difco, supplemented with 5% defibrinated horse blood) 30 °C for 24 h). All samples fell in the range 'fit for consumption'. At slaughter, there was no difference in ASAT activity, urea and Cortisol concentrations between the two transported groups. However, the plasma ASAT activity and urea concentrations at slaughter were significantly lower in the non-transported group. In both transport groups, the plasma Cortisol concentrations increased during loading onto and unloading from the lorry. Abomasal lesions were observed in all treatment groups. It was concluded that reindeer showed an acute stress response to manual handling and transport

A suspected virus infection of the oral mucosa in Swedish reindeer (Rangifer tarandus L)

In 1980 a rather high frequency of reindeer, supplementarily fed in pens, were taken ill and deaths occurred as well. In five out of eight carcasses necrophsied oral lesions were observed. Histologically the mucosa, surrounding these lesions, was charasterized by the presence of intracytoplasmic inclusion bodies, inter- and intracellular oedema and vesicle formation. Fusobacterium necrophorum, Coll, betahaemolizing streptococci, and Cory neb acterium pyogenes found in the lesions were all considered secondary invaders. Serological samples from disease stricken herds were tested for antibodies against BVD-, P13-, and IBR-virus as well as Chlamydia. Low positive titres were observed but for BVDV. The result indicates that a thus far unidentified virus might be the primary cause of this enzootically occurring disease

The demonstration of a herpesvirus, related to bovine herpesvirus 1, in reindeer with ulcerative and necrotizing lesions of the upper alimentary tract and nose

In 11 male reindeer, all esposed to transportation stress, signs of conjunctivitis and later on ulcerative and necrotizing lesions of the mucosa of the nostrils and mouth were recorded. Blood and secretions from the nose were sampled. Antibodies to bovine herpesvirus 1 (BHV-1) were detected in 2 animals. No animal had antibodies to bovine viral diarrhoea virus (BVDV). Virus isolation was negative. The sampling was repeated 2 weeks later and complemented with biopsies from the mouth lesions, fixed in formalin. At this occasion 3 animals were seropositive to BHV-1 and in biopsies from 2 of these intranuclear herpesvirus-like particles were found by means of electron microscopy. Four animals, 3 of them seropositive, were treated with cortison during 8 days. The size of the ulcers in the mouth increased in all animals. A herpesvirus was isolated from 3 of them at 10 different occasions. The ultrastructural investigation of the virus suspension demonstrated the presence of typical herpesvirus particles. On day 11 all 4 animals suffered from a severe diarrhoea and anorexia. On day 12 one animal died and on day 13 post challenge with cortison two additional animals died. The remaining animal was slaughtered on day 13. Bacteriological investigation revealed growth of Fusobacterium necrophorum from the spleen and oral wounds of all 4 animals. The animals were obviously subjected to an infection with a herpesvirus colsely related to BHV-1. Virus could be liberated by cortison treatment. It is possible that infections with the found herpesvirus, and the lesions caused by it, may be the background to earlier recorded severe outbreaks of necrobacillosis of the alimentary tract in reindeer herds

Precautionary Regulation in Europe and the United States: A Quantitative Comparison

Much attention has been addressed to the question of whether Europe or the United States adopts a more precautionary stance to the regulation of potential environmental, health, and safety risks. Some commentators suggest that Europe is more risk-averse and precautionary, whereas the US is seen as more risk-taking and optimistic about the prospects for new technology. Others suggest that the US is more precautionary because its regulatory process is more legalistic and adversarial, while Europe is more lax and corporatist in its regulations. The flip-flop hypothesis claims that the US was more precautionary than Europe in the 1970s and early 1980s, and that Europe has become more precautionary since then. We examine the levels and trends in regulation of environmental, health, and safety risks since 1970. Unlike previous research, which has studied only a small set of prominent cases selected non-randomly, we develop a comprehensive list of almost 3,000 risks and code the relative stringency of regulation in Europe and the US for each of 100 risks randomly selected from that list for each year from 1970 through 2004. Our results suggest that: (a) averaging over risks, there is no significant difference in relative precaution over the period, (b) weakly consistent with the flip-flop hypothesis, there is some evidence of a modest shift toward greater relative precaution of European regulation since about 1990, although (c) there is a diversity of trends across risks, of which the most common is no change in relative precaution (including cases where Europe and the US are equally precautionary and where Europe or the US has been consistently more precautionary). The overall finding is of a mixed and diverse pattern of relative transatlantic precaution over the period