5 research outputs found
Real life outcomes of patients aged â„75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry
PETHEMA And PALG Groups.Acute promyelocytic leukemia is infrequent among patients aged â„75 years old, a population that is rarely eligible for clinical protocols. This study aims to analyze the treatment strategies and clinical outcomes of very old APL patients reported to the international PETHEMA registry. Between 1997 and 2017, among 2501 APL cases registered 120 were â„75 years old. Treatment approaches were: AIDA regimen, 79 patients; ATRA alone, 23; 16, supportive care (SC) and 2, other strategies. Patients treated with AIDA were younger, had better ECOG and lower leukocytes. Complete remission (CR) was achieved in 65% of AIDA-group vs. 45% in the ATRA-group, being infections followed by bleeding the most frequent causes of induction death. Patients in CR after AIDA showed 3-year DFS of 73%. Our real-life series of very old APL patients provides a reference basis for future treatment strategies aiming to improve clinical outcomes in this challenging population.This work was partially financed with FEDER Funds (CIBERONC (CB16/12/00284))
Evolving treatment patterns and outcomes in older patients (â„60 years) with AML: changing everything to change nothing?
There are no studies analyzing how therapeutic changes impact on outcomes of older AML patients. This study analyzes patientÂŽs and disease characteristics, treatment patterns, and outcomes of 3637 AML patients aged â„60 years reported to the PETHEMA registry. Study periods were 1999â2006 (before hypomethylating agents-HMAs availability) vs 2007â2013, and treatments were intensive chemotherapy (IC), non-intensive, clinical trial (CT), and supportive care only (SC). Median age was 72 (range, 60â99), 57% male, median ECOG 1 (range, 0â4), secondary AML 914 (30%), with adverse-risk genetic in 720 (32%). Treatment differed between study periods (1999â2006 vs 2007â2013): IC 58% vs 32%, non-intensive 1 vs 23%, CT 0 vs 2%, SC 27 vs 28% (pâ<â0.001). Median OS was 4.7 months (1-year OS 29% and 5-years 7%, without differences between periods), 1.2 for SC, 7.8 for non-intensive, 8.6 for IC, and 10.4 for CT (pâ<â0.001). OS improved in the 2007â2013 period for IC patients (10.3 vs 7.5 months, pâ=â0.004), but worsened for SC patients (1.2 vs 1.6 months, pâ=â0.03). Our real-life study shows that, despite evolving treatment for elderly patients during the last decade, OS has remained unchanged. Epidemiologic registries will critically assess whether novel therapies lead to noteworthy advances in the near future (#NCT02606825).This study was supported in part by Janssen Pharmaceutica, and the Cooperative Research Thematic Network (RTICC) (Grant RD12/0036/014 (ISCIII & ERDF)
PromociĂłn turĂstica sostenible de la reserva de la biosfera Tajo-Tejo Internacional
Convocatoria proyectos de innovaciĂłn de Extremadura 2020/2021Se describe un proyecto llevado acabo por varios centros educativos ubicados en la zona de la Reserva de la Biosfera Tajo-Tejo Internacional (RBTTI) que pretendĂa contribuir a la transformaciĂłn sostenible del entorno mediante su conocimiento y promociĂłn, implementando las competencias digital, social y ciudadana y la cultura emprendedora mediante metodologĂas activas como el aprendizaje servicio. Entre los objetivos principales del proyecto destacan: dar a conocer las implicaciones de la RBTTI; diseñar una campaña de promociĂłn de la RBTTI mediante trĂpticos y vĂdeos promocionales; conocer la Reserva a travĂ©s de las principales vĂas pecuarias y caminos que comunican los pueblos; descubrir los principales elementos socioculturales, histĂłricos y tradicionales de la Reserva; valorar la importancia del territorio para conservar la biodiversidad: paisajes, ecosistemas, fauna y flora representativa; relacionar la trashumancia y las vĂas pecuarias como rasgos identificativos de la Reserva, vinculĂĄndolo con la historia y rasgos culturales de los pueblos y valorar el emprendimiento y la iniciativa personal, el asosiacionismo y creaciĂłn de redes de cooperaciĂłn en y entre pueblos como motor de desarrolloExtremaduraES