Dynamic FOV visible light communications receiver for dense optical networks

This study explores how the field-of-view (FOV) of a visible light communications (VLCs) receiver can be manipulated to realise the best signal-to-noise ratio (SNR) while supporting device mobility and optimal access point (AP) selection. The authors propose a dynamic FOV receiver that changes its aperture according to receiver velocity, location, and device orientation. The D-FOV technique is evaluated through modelling, analysis, and experimentation in an indoor environment comprised of 15 VLC APs. The proposed approach is also realised as an algorithm that is studied through analysis and simulation. The results of the study indicate the efficacy of the approach including a 3X increase in predicted SNR over static FOV approaches based on measured received signal strength in the testbed. Additionally, the collected data reveal that D-FOV increases effectiveness in the presence of noise. Finally, the study describes the tradeoffs among the number of VLC sources, FOV, user device velocity, and SNR as a performance metric.Accepted manuscrip

Artificial intelligent smart home automation with secured camera management-based GSM, cloud computing, and arduino

oai:ojs.pen.ius.edu.ba:article/1718Home management and controlling have seen a great introduction to network that enabled digital technology, especially in recent decades. For the purpose of home automation, this technique offers an exciting capability to enhance the connectivity of equipment within the home. Also, with the rapid expansion of the Internet, there are potentials that added to the remote control and monitoring of such network-enabled devices. In this paper, we had been designed and implemented a fully manageable and secure smart home automation system based on a cloud computing system with an ESP Arduino system. The security of home had been improved by adding a complete camera system with a GSM communication technique to connect the Arduino output data to an external specified number if there is no internet provider. We used three sensors for temperature, gas, and motion measurements. The ESP8226 Wi-Fi device programmed the sensors to maintain the sensors measurements and transfer them to the cloud server database which is programmed to the web server via Appatshy and Mysql formats. The system implemented with high time response so that all readings updated and appeared spontaneously. The designed system should be effective, a secure, and rapid response real-time smart home system should be achieved

Artificial intelligent smart home automation with secured camera management-based GSM, cloud computing and arduino

Home management and controlling have seen a great introduction to network that enabled digital technology, especially in recent decades. For the purpose of home automation, this technique offers an exciting capability to enhance the connectivity of equipment within the home. Also, with the rapid expansion of the Internet, there are potentials that added to the remote control and monitoring of such network-enabled devices. In this paper, we had been designed and implemented a fully manageable and secure smart home automation system based on a cloud computing system with an ESP Arduino system. The security of home had been improved by adding a complete camera system with a GSM communication technique to connect the Arduino output data to an external specified number if there is no internet provider. We used three sensors for temperature, gas, and motion measurements. The ESP8226 Wi-Fi device programmed the sensors to maintain the sensors measurements and transfer them to the cloud server database which is programmed to the web server via Appatshy and Mysql formats. The system implemented with high time response so that all readings updated and appeared spontaneously. The designed system should be effective, a secure, and rapid response real-time smart home system should be achieved

Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening

There is interest in developing inhibitors of human neutral ceramidase (nCDase) because this enzyme plays a critical role in colon cancer. There are currently no potent or clinically effective inhibitors for nCDase reported to date, so we adapted a fluorescence-based enzyme activity method to a high-throughput screening format. We opted to use an assay whereby nCDase hydrolyzes the substrate RBM 14-16, and the addition of NaIO4 acts as an oxidant that releases umbelliferone, resulting in a fluorescent signal. As designed, test compounds that act as ceramidase inhibitors will prevent the hydrolysis of RBM 14-16, thereby decreasing fluorescence. This assay uses a 1536-well plate format with excitation in the blue spectrum of light energy, which could be a liability, so we incorporated a counterscreen that allows for rapid selection against fluorescence artifacts to minimize false-positive hits. The high-throughput screen of >650,000 small molecules found several lead series of hits. Multiple rounds of chemical optimization ensued with improved potency in terms of IC50 and selectivity over counterscreen assays. This study describes the first large-scale high-throughput optical screening assay for nCDase inhibitors that has resulted in leads that are now being pursued in crystal docking studies and in vitro drug metabolism and pharmacokinetics (DMPK).National Cancer Institute https://doi.org/10.13039/100000054Stony Brook Cancer CenterPeer Reviewe

The importance of socio-economic context for social marketing models for improving reproductive health: Evidence from 555 years of program experience

BACKGROUND: Over the past two decades, social marketing programs have become an important element of the national family planning and HIV prevention strategy in several developing countries. As yet, there has not been any comprehensive empirical assessment to determine which of several social marketing models is most effective for a given socio-economic context. Such an assessment is urgently needed to inform the design of future social marketing programs, and to avoid that programs are designed using an ineffective model. METHODS: This study addresses this issue using a database of annual statistics about reproductive health oriented social marketing programs in over 70 countries. In total, the database covers 555 years of program experience with social marketing programs that distribute and promote the use of oral contraceptives and condoms. Specifically, our analysis assesses to what extent the model used by different reproductive health social marketing programs has varied across different socio-economic contexts. We then use random effects regression to test in which socio-economic context each of the models is most successful at increasing use of socially marketed oral contraceptives and condoms. RESULTS: The results show that there has been a tendency to design reproductive health social marketing program with a management structure that matches the local context. However, the evidence also shows that this has not always been the case. While socio-economic context clearly influences the effectiveness of some of the social marketing models, program maturity and the size of the target population appear equally important. CONCLUSIONS: To maximize the effectiveness of future social marketing programs, it is essential that more effort is devoted to ensuring that such programs are designed using the model or approach that is most suitable for the local context

The Topos of Music III: Gestures Musical Multiverse Ontologies

New element of the Topos book brings together progress in diverse field Presents gesture theory, including a gesture philosophy for music, the mathematics of gestures, concept architectures and software for musical gesture theory, and the multiverse perspective Presents applications of gesture theory, including counterpoint, modulation theory, and free jaz