Research-based spin-offs targeting the market for technologies: a conceptual model

DINÂMIA, Dezembro de 2009.This paper addresses the commercialisation decisions of research-based spin-off firms, focusing on the case of companies specialising in the production and sale of intellectual property - a model of entrepreneurial behaviour increasingly frequent in science-based fields, and that research-based spin-offs may be more prone to adopt given their specific characteristics. Combining insights from the economics of technological change and the strategic management of technology literature, we discuss the conditions that influence spin-offs ability to pursue with this strategy, and advance some theory-driven hypothesis regarding key factors that are likely to determine their choice - nature of knowledge, appropriability conditions, location and degree of control upon complementary assets and institutional setting of origin - and their impact upon firms’ decisions. We add to the still incipient research on this model of behaviour, as well as to recent research on the determinants of the commercialisation strategy of small technologyintensive firms.FC

New phototriggers based on coumarins with extended π-systems

Comunicação em painel P35 no XXIV Encontro Nacional da Sociedade de Portuguesa de Química, Coimbra, Portugal, 1-3 Julho 2015The present work describes the synthesis of new coumarin derivatives possessing an extended π-system, in order to bathocromically shift the wavelength of maximum absorption, and consequently of photolysis. These compounds were tested as phototriggers of two neurotransmitter amino acids, glycine and β-alanine, at 254, 300, 350 and 419 nm, in a Rayonet RPR-100 photochemical reactor, and the release of the active compound was monitored by HPLC-UV detection, with collection of kinetic data.Fundação para a Ciência e Tecnologia (FCT, Portugal) for financial support to the NMR portuguese network (PTNMR, Bruker Avance III 400-Univ. Minho), FCT and FEDER (European Fund for Regional Development) -COMPETE-QREN-EU for financial support to Research Centre of Chemistry, CQ/UM [PEst-C/QUI/UI0686/2013 (FCOMP -01-0124-FEDER-037302)]info:eu-repo/semantics/publishedVersio

Photorelease of neurotransmitter amino acids from coumarin derivatives

Comunicação em painel QS43 no livro de resumos do XX Encontro Luso-Galego de QuímicaIn this work it is presented the photorelease of two model neurotransmitter amino acids, namely glycine and β-alanine, from two different coumarins. These model neurotransmitters were chosen due to their biological importance as well as their pharmacological activities. The coumarin-amino acid conjugates were irradiated at 245, 300, 350 and 419 nm using a Rayonet RPR-100 photochemical reactor and the release of the active compound was monitored by HPLC-UV detection, with collection of kinetic data.Fundação para a Ciência e a Tecnologia (FCT

Photorelease of glycine and β-alanine from (7-bromocoumarin-4-yl)methyl cages

Comunicação eletrónica a015 no 19th Int. Electron. Conf. Synth. Org. Chem., Novembro 2015.With the goal of evaluating the efficiency of 4-chloromethyl-7-bromocoumarin as phototrigger for amino acid neurotransmitters glycine and β-alanine, the corresponding ester conjugates were synthetized. Their irradiation at different wavelengths (254, 300, 350 and 419 nm) in a Rayonet RPR-100 photochemical reactor, in methanol/HEPES buffer (80:20) was carried out. The photolysis process was followed by HPLC with UV detection. Results will be discussed in comparison with those obtained when 4-chloromethyl-7-aminocoumarin was used in the photorelease of glycine and β-alanine.info:eu-repo/semantics/publishedVersio