Association of TIM-1 5383-5397ins/del and TIM-3-1541C > T polymorphisms with multiple sclerosis in Isfahan population

Multiple sclerosis (MS) is an organ-specific autoimmune disease in central nervous system, affecting about 2.5 million people around the world. Probable involvement of two newly identified immunoregulator molecules, TIM-1 and TIM-3, has been reported in autoimmune diseases. In this study, for the first time, the association of TIM-1 5383-5397ins/del and TIM-3 -1541C>T polymorphisms with MS in an Iranian population was considered. The results of our study showed that there is no significant association between TIM-1 5383-5397ins/del and MS (P = 0.38); however, the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS (P = 0.009, OR = 4.08)

Application of nano-packaging in aquatics

BACKGROUND: Aquatics specially fish is considered one of the most decaying food stuff. Having less connective tissues, more nonsaturated fatty acid, free amino acids and more anzyme activities are the factors influencing fish deterioration. In response to consumers demands for food with the least preservatives, new technologies in the food industry is important. Therefore, in this review article, the application of nano technology in aquatics packaging was studied. Methods: Search by the keywords “Packaging Nano Aquatics” in databases Pubmed, Scopus and Web of Science were done and then 30 related articles that published in 2000-2017 were selected. Findings: In this research, 30 related articles were found. One of the most important packagings is nano-packaging occurring by nanotechnology science. There are much nano-material in packaging including clay polymeical nano composities as nonpreamation matters, which on aquatics, absent of oxygen which itself is a barrier to oxidant reactions is of much importance in increasing survivability. Conclusion: With regard to aquatics high nutritional value and their important presence in diet one should think of a way to increase it's survivability and maintaining quality. For this, nano technology can help packaging aquatics. Nano can be applied considerably in food health and environment protection