Time management on task completion of science, technology, engineering, and mathematics (STEM) students of ECT Excellencia Global Academy Foundation, Inc.

Time management is a collection of skills that you may use to make the most of your time and enhance your quality of life. Most commonly, students would find meaning, accomplishment, and even fulfillment once achieved the objectives that they set. This is possible because they wisely manage their time. Henceforth, this research study will shed light a report on the concept of time management that significantly affects towards the STEM students’ of ECT Excellencia Global Academy Foundation, Inc. (EEGAFI) on their potentiality to complete their tasks on time. To determine the limitations of students’ time management, hypotheses were developed along with the problems and objectives of this study. The respondents of this study were from the students of STEM 11 of EEGAFI. 150 respondents were randomly selected and these students were those who volunteered to participate in the surveys were picked at random from the group. The researchers gave the predetermined questionnaires to the respondents in this research study with the primary goal of collecting data for statistical analysis. The findings showed that time management behaviors such as procrastination, prioritizing, and planning had a significant impact on the task completion of the students. When doing task completion, it is advised that students pay close attention to the passing of time. Efforts to ensure strong academic success. Given that procrastination, when compared to other factors, significantly affects academic achievement, the results show that students need work very hard to finish their projects as well as completing all other academic tasks on time to avoid missing deadlines

Life-Cycle Performance Assessment of Road Network Under Multiple Hazards

A procedure for estimating risk and resilience of road networks associated with bridges and embankments subjected to seismic ground motion and subsequent tsunami caused by the anticipated Nankai Trough earthquake is proposed. Since road networks play a crucial role for the transportation system after a natural disaster, it is important to identify the degradation of functionality and economic loss due to damage to structures in networks. In an illustrative example, risk and resilience of road networks in Mie-Prefecture, where the effects of Nankai Trough earthquake would be very intense, are estimated. The numerical results show that the retrofitting prioritization can be determined by comparing the risk and resilience of road networks.The authors express sincere appreciation to Dr. Masayuki Yoshimi, National Institute of Advanced Industrial Science and Technology of Japan, for his suggestions related to seismic fault parameters

Inheritance and allelic relationships of anthracnose resistance in common bean paloma cultivar

Anthracnose, caused by Colletotrichum lindemuthianum L., is one of the most important fungal diseases of common bean (Phaseolus vulgaris, L). Genetic resistance is the most effective method for this disease control. So far, twenty one resistance genes have been already characterized, and among them, only eight are Andean and due to it, the search for Andean resistance sources is really necessary. This way, the work aimed to characterize the genetic resistance of an Andean common bean cultivar.Fil: Castro, S. A. L.. Universidade Estadual de Maringá; BrasilFil: Gonçalves Vidigal, M. C.. Universidade Estadual de Maringá; BrasilFil: Nanami, D. S. Y.. Universidade Estadual de Maringá; BrasilFil: Frias, A. A. T.. Universidade Estadual de Maringá; BrasilFil: Franzon, R. C.. Universidade Estadual de Maringá; BrasilFil: Poletine, J. P.. Universidade Estadual de Maringá; BrasilFil: Lacanallo, G. F.. Universidade Estadual de Maringá; BrasilFil: Galván, Marta Zulema. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Salta-Jujuy. Estación Experimental Agropecuaria Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta; Argentin

Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier

Lipid-protein interactions play a multitude of essential roles in membrane homeostasis. Mitochondrial membranes have a unique lipid-protein environment that ensures bioenergetic efficiency. Cardiolipin (CL), the signature mitochondrial lipid, plays multiple roles in promoting oxidative phosphorylation (OXPHOS). In the inner mitochondrial membrane, the ADP/ATP carrier (AAC in yeast; adenine nucleotide translocator, ANT in mammals) exchanges ADP and ATP, enabling OXPHOS. AAC/ANT contains three tightly bound CLs, and these interactions are evolutionarily conserved. Here, we investigated the role of these buried CLs in AAC/ANT using a combination of biochemical approaches, native mass spectrometry, and molecular dynamics simulations. We introduced negatively charged mutations into each CL-binding site of yeast Aac2 and established experimentally that the mutations disrupted the CL interactions. While all mutations destabilized Aac2 tertiary structure, transport activity was impaired in a binding site-specific manner. Additionally, we determined that a disease-associated missense mutation in one CL-binding site in human ANT1 compromised its structure and transport activity, resulting in OXPHOS defects. Our findings highlight the conserved significance of CL in AAC/ANT structure and function, directly tied to specific lipid-protein interactions

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Abstract: The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B.1.1.7 (Alpha)1. In vitro, B.1.617.2 is sixfold less sensitive to serum neutralizing antibodies from recovered individuals, and eightfold less sensitive to vaccine-elicited antibodies, compared with wild-type Wuhan-1 bearing D614G. Serum neutralizing titres against B.1.617.2 were lower in ChAdOx1 vaccinees than in BNT162b2 vaccinees. B.1.617.2 spike pseudotyped viruses exhibited compromised sensitivity to monoclonal antibodies to the receptor-binding domain and the amino-terminal domain. B.1.617.2 demonstrated higher replication efficiency than B.1.1.7 in both airway organoid and human airway epithelial systems, associated with B.1.617.2 spike being in a predominantly cleaved state compared with B.1.1.7 spike. The B.1.617.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike. We also observed that B.1.617.2 had higher replication and spike-mediated entry than B.1.617.1, potentially explaining the B.1.617.2 dominance. In an analysis of more than 130 SARS-CoV-2-infected health care workers across three centres in India during a period of mixed lineage circulation, we observed reduced ChAdOx1 vaccine effectiveness against B.1.617.2 relative to non-B.1.617.2, with the caveat of possible residual confounding. Compromised vaccine efficacy against the highly fit and immune-evasive B.1.617.2 Delta variant warrants continued infection control measures in the post-vaccination era